Conserved Protein Domain Family
Ig_Sema4B_like

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cd05872: Ig_Sema4B_like 
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
The members here are composed of the immunoglobulin (Ig)-like domain of Sema4B and similar proteins. Sema4B is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4B has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4B has been shown to preferentially regulate the development of the postsynaptic specialization at the glutamatergic synapses. This cytoplasmic domain includes a PDZ-binding motif upon which the synaptic localization of Sem4B is dependent. Sema4B is a ligand of CLCP1. CLCP1 was identified in an expression profiling analysis, which compared a highly metastic lung cancer subline with its low metastic parental line. Sema4B was shown to promote CLCP1 endocytosis and their interaction is a potential target for therapeutic intervention of metastasis.
Statistics
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PSSM-Id: 409456
View PSSM: cd05872
Aligned: 8 rows
Threshold Bit Score: 104.06
Threshold Setting Gi: 8134694
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to the human class IV semaphorin, SEMA4D.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #                                           #                      
XP_421725    543 LPWKNRTVLR-GDDVLLPCDQRSNLARAVWLLNGSEVpgt-gqeRLRVGv--DGLLVTNTlpgHSGEYRCYGEERGLXTL 618 chicken
CAG06556     515 VTHRKRSVMA-GDDVLLQCELRSNLASPRWTLNGRELmgyglnsGYRIGt--DGLLIIGAraqQSGTYRCFAVENSVSVL 591 Tetraodon nigro...
AAH78116     556 PFVKNITVGI-GTNVVLPCQLSSNLAQPVWTFNGQDLesd-qddSVLFDttlQALVILGVgthHSGCYVCYSEEQGTQLT 633 African clawed ...
NP_001084878 557 LKKKVRTVIK-GNDVLLQCDLRSNLARPQWYVNGTNKlyn-segHTRLGv--DGLLITDTlpeHSGEYNCYSEENGLQSL 632 African clawed ...
XP_413950    217 TPCQRIQLPP-NAVQPLPCRLLSNLASRRWLHNGTPVna----sYLVLP---EGALILVGspeRAGTYECWSLEEGFRKL 288 chicken
AAH10701     287 KPCEQVQFQP-NTVNTLACPLLSNLATRLWLRNGAPVnas--asCHVLP---TGDLLLVGt-qQLGEFQCWSLEEGFQQL 359 human
XP_001338626 521 AAVLFKTAHL-NEIVVLPCQSKSKLAKMTWRFSNNSLvpq--fpYLQWT---DGSLVFPVsleTTNTYRCVSEELGFQQT 594 zebrafish
O95754       569 RPVVFEVPVAtAAHVVLPCSPSSAWASCVWHQPSGVT-------ALTPRr--DGLEVVVTp-gAMGAYACECQEGGAAHV 638 human
Feature 1                   
XP_421725    619 LAAYSLTVLPQ 629 chicken
CAG06556     592 VFLYSVRVHTD 602 Tetraodon nigroviridis
AAH78116     634 AESYQLTVVAS 644 African clawed frog
NP_001084878 633 IAAYSLNVLLE 643 African clawed frog
XP_413950    289 MASYCVAVQEP 299 chicken
AAH10701     360 VASYCPEVVED 370 human
XP_001338626 595 IATFSVNLPVV 605 zebrafish
O95754       639 VAAYSLVWGSQ 649 human

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