Conserved Protein Domain Family
Ig_Sema3

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cd05871: Ig_Sema3 
Immunoglobulin (Ig)-like domain of class III semaphorin Sema3
The members here are composed of the immunoglobulin (Ig)-like domain of Sema3 and similar proteins. Semaphorins are classified based on structural features additional to the Sema domain. Sema3 is a Class III semaphorin that is secreted. It is a vertebrate class having a Sema domain, an Ig domain, a short basic domain. They have been shown to be axonal guidance cues and have a part in the regulation of the cardiovascular, immune, and respiratory systems. Sema3A, the prototype member of this class III subfamily, induces growth cone collapse and is an inhibitor of axonal sprouting. In perinatal rat cortex, it acts as a chemoattractant and functions to direct the orientated extension of apical dendrites. It may play a role, prior to the development of apical dendrites, in signaling the radial migration of newborn cortical neurons towards the upper layers. Sema3A selectively inhibits vascular endothelial growth factor receptor (VEGF)-induced angiogenesis and induces microvascular permeability. This group also includes Sema3B, -C, -D, -E, -G.
Statistics
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PSSM-Id: 409455
View PSSM: cd05871
Aligned: 12 rows
Threshold Bit Score: 119.374
Threshold Setting Gi: 8134673
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to the human class IV semaphorin, SEMA4D.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #                                                       #          
Q14563     579 SPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEerkee-----------irvdDHIIRTDQGLLLRSLQQKDSGNY 647  Homo sapiens
O95025     595 TADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSGDehree-----------lkpdERIIKTEYGLLIRSLQKKDSGMY 663  human
Q13214     574 ALLEHKVFGVEGSSAFLECEPRSLQARVEWTFQRAGVtahtq-----------vlaeERTERTARGLLLRRLRRRDSGVY 642  human
Q9NS98     585 LVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDegpdq-----------vktdERVLHTERGLLFRRLSRFDAGTY 653  human
CAF93083  1148 PLEVKVVYGVEGNSSFLECLGRWPQAELRWTFQRTEKqhqgggwsrdsremplrgdeDHLVLMGRGLLLRHLQLAHSGVF 1227 Tetraodon nigrov...
O15041     584 KTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGREtrkee-----------vktdDRVVKMDLGLLFLRLHKSDAGTY 652  human
CAK11088   524 NAELKTVYGVETNSTFLECVSNSPQATIKWIFQPNHSqnske----------lvpgeENLLHMQRGLLLQQITSTNAGLY 593  zebrafish
XP_414276  550 AAVEQPVFGVEKNSTFLECRARSPQTAVRWLARRGEGpglse-----------vrsgGRVAVLEQGLLIRQLGREDAGTY 618  chicken
AAH84294   572 NTAEIVQYGVRNNTTFLECISKSPQASVKWLLQKDNDrrke------------vklnERIIATGQGLFIRSVQETDQGVY 639  African clawed frog
O42236     574 NAAETVQYGVKNNTTFLECTPKSPQASIKWLLQKDNDrrke------------vklsERIIATEQGLLIRSVQDSDRGLY 641  chicken
AAI24870   573 GISERLQIGVEGGSVFLQCDTHSPLESVTWLLQREGSqhr---------------reVRLAGIDGGAVLRSVQASDAGVY 637  African clawed frog
NP_571125  568 EAEEKTLVVAVGNSTYLECLPKSHHATITWYKDIGENsleqh----------rvtsgEQLLVIDRGILIPRAELNHAGVY 637  zebrafish
Feature 1                             
Q14563     648 LCHAVEHGFIQTLLKVTLEVIDT 670  Homo sapiens
O95025     664 YCKAQEHTFIHTIVKLTLNVIEN 686  human
Q13214     643 LCAAVEQGFTQPLRRLSLHVLSA 665  human
Q9NS98     654 TCTTLEHGFSQTVVRLALVVIVA 676  human
CAF93083  1228 TCTSHERSFSQALARYRLHVIAS 1250 Tetraodon nigroviridis
O15041     653 FCQTVEHSFVHTVRKITLEVVEE 675  human
CAK11088   594 LCMAFEHSFSRTLARYELHVIPQ 616  zebrafish
XP_414276  619 ECQAVEHSFSRPLTRYSLHVIRH 641  chicken
AAH84294   640 HCVATENTFKQTITKVNLKVLEP 662  African clawed frog
O42236     642 HCIATENNFKQTLAKINFKVLDT 664  chicken
AAI24870   638 TCTGTENGFRRSRGKIRLNVLPR 660  African clawed frog
NP_571125  638 HCQLEEHGFRWTAVTIRLTVWSP 660  zebrafish

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