Conserved Protein Domain Family
Ig4_L1-CAM_like

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cd05867: Ig4_L1-CAM_like 
Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
The members here are composed of the fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region, and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM.
Statistics
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PSSM-Id: 409453
View PSSM: cd05867
Aligned: 3 rows
Threshold Bit Score: 166.609
Threshold Setting Gi: 1171701
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Aligned Rows:
 
Feature 1:Ig strand B [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #####                                                           
1171701    328 YWVRRPQSGVFGPGETARLDCEVGGKPRPQIQWSINGVPieaagae-rrwlrgGALVLPELRPNDSAVLQCEARNRHGPL 406  chicken
1705571    334 YWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPveelakdqkyriqrGALILSNVQPSDTMVTQCEARNRHGLL 413  human
AAA99159   303 YWTRRPENHLYAPGETVRLDCQAEGIPTPNITWSMNGAPiagtdpdprrhvssGTLILTDVQISDTAVYHVEATNKHGNI 382  goldfish
Feature 1               
1171701    407 LANAFLHVV 415  chicken
1705571    414 LANAYIYVV 422  human
AAA99159   383 LINTHVHVV 391  goldfish

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