5OYJ


Conserved Protein Domain Family
IgI_VEGFR-2

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cd05864: IgI_VEGFR-2 
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2); member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. VEGFRs bind VEGFs with high affinity at the Ig-like domains. VEGFR-2 (KDR/Flk-1) is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A; VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGF-A also interacts with VEGFR-1, which it binds more strongly than VEGFR-2. VEGFR-1 and VEGFR-2 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.
Statistics
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PSSM-Id: 409450
View PSSM: cd05864
Aligned: 4 rows
Threshold Bit Score: 159.323
Threshold Setting Gi: 209743752
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      ####                                                                            
5OYJ_C       8 FVAFgsgmesLVEATV-GERVRIPAKYLGYPPPEIKWYKNGIPL----ESNHTIKAGHVLTIMEVSERDTGNYTVILTNP 82   human
9087218    329 FVAFgsgmesLVEATV-GERVRIPAKYLGYPPPEIKWYKNGIPL----ESNHTIKAGHVLTIMEVSERDTGNYTVILTNP 403  human
Q5GIT4     336 FIALsdqlwqTVEAKAgDAEAKILVKYYAYPEPAVRWYKNDQLIvlrdEYRMKFYRGVHLTIYGVTEKDAGNYTVVMTNK 415  zebrafish
P52583     321 FIHLekm-enVVEMKL-GDTVSIPVKFKGYPPPEAKWYKNGKVI----NANHTVKLGYALVITEATEKDAGNYTVVLTNP 394  Japanese quail
Feature 1                    
5OYJ_C      83 ISKEKQSHVVSLVV 96   human
9087218    404 ISKEKQSHVVSLVV 417  human
Q5GIT4     416 ITKEEQRRTFQLVV 429  zebrafish
P52583     395 TNKMQKRHTFTLLV 408  Japanese quail

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