4BSJ


Conserved Protein Domain Family
IgI_VEGFR-3

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cd05863: IgI_VEGFR-3 
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3); member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. VEGFRs bind VEGFs with high affinity at the Ig-like domains. VEGFR-3 (Flt-4) binds two members of the VEGF family (VEGF-C and VEGF-D) and is involved in tumor angiogenesis and growth. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.
Statistics
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PSSM-Id: 409449
View PSSM: cd05863
Aligned: 4 rows
Threshold Bit Score: 165.11
Threshold Setting Gi: 82072489
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       ######                                                                         
4BSJ_A       4 PFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALsgRHSp------HALVLKEVTEASTGTYTLALWNS 77   human
Q5MD89     352 PFISLDYRNGSVIEAKEGQKSVRLSVKVSAYPSPEIQWYKNGKLIssKNSsrfkvqqHSLQIRDVCKQDAGEYMLVLKNS 431  zebrafish
P35916     331 PFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALsgRHSp------HALVLKEVTEASTGTYTLALWNS 404  human
P79701     340 PFINVEWRKGPVIEATAGDEAVKLPVKVVAYPQPDFQWYKAGKLIp-KQSq------SSMQIKDVAEHHAGTYTLVLRNR 412  common quail
Feature 1                    
4BSJ_A      78 AAGLRRNISLELVV 91   human
Q5MD89     432 PAALEKRLNFTLIV 445  zebrafish
P35916     405 AAGLRRNISLELVV 418  human
P79701     413 LVGLEKRISLQLIV 426  common quail

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