3V6B


Conserved Protein Domain Family
IgI_VEGFR

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cd05862: IgI_VEGFR 
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); member of the I-set of IgSF domains
The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members, VEGFR-1 (also known as Flt-1), VEGFR-2 (also known as KDR or Flk-1) and VEGFR-3 (also known as Flt-4). VEGF_A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF, VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-2 and -1 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth.
Statistics
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PSSM-Id: 409448
View PSSM: cd05862
Aligned: 8 rows
Threshold Bit Score: 164.923
Threshold Setting Gi: 209743752
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #####                                                                           
3V6B_R      94 YDVVLsps-hgIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKhqhKKLVNRDLKtqsg-----semKKFLSTLTIDGV 167  human
P35916     230 YDIQLlpr-ksLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQaerGKWVPERRSqq--------thTELSSILTIHNV 300  human
P52583     219 YDLTMnph-yqVELAVGEKLVLNCTVRTELNVGIDFRWDYPSIKe--RRATIRDLKtta------geiKTFVSTLTIESV 289  Japanese quail
Q5GIT4     227 YDLTLsp--qhERLTVGERLILNCTAHTELNVGIDFQWTFPHEKrsvNGSMSTSRYktssnkkklwnsLELSNTLTVENV 304  zebrafish
P79701     239 YDIQLypk-kaMELLVGEKLVLNCTVWAEFNSGVRFQWTYPGKQm-qRAVIESERRslq-------thTELSSILTLHNV 309  common quail
9087218    224 YDVVLsps-hgIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKhqhKKLVNRDLKtqsg-----semKKFLSTLTIDGV 297  human
Q5MD89     249 YEFKLfpedspVELMQGESLVLNCTALVDFNTGVDFQWDYPGKKenrLASLQPLRNvld-------eaTEISSILSIRNI 321  zebrafish
P17948     230 IDVQIstp-rpVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKn-kRASVRRRIDqsn------shaNIFYSVLTIDKM 301  human
Feature 1                                   
3V6B_R     168 TRSDQGLYTCAASSGLMTKKNSTFVRVHE 196  human
P35916     301 SQHDLGSYVCKANNGIQRFRESTEVIVHE 329  human
P52583     290 NLSDKGRYTCAASSGRMNMKNSSYFIIHE 318  Japanese quail
Q5GIT4     305 TLNDTGEYICTASSGQMQKIAQASLIVYE 333  zebrafish
P79701     310 SQQDLGRYTCTATNGAQMLEESTDVIVHE 338  common quail
9087218    298 TRSDQGLYTCAASSGLMTKKNSTFVRVHE 326  human
Q5MD89     322 HLDDSGYYTCWANTLEMKRELTTVVIVHE 350  zebrafish
P17948     302 QNKDKGLYTCRVRSGPSFKSVNTSVHIYD 330  human

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