Conserved Protein Domain Family
IgI_PDGFR-alphabeta

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cd05861: IgI_PDGFR-alphabeta 
Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha and beta; member of the I-set of IgSF domains
The members here are composed of the immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (also known as cluster of differentiation (CD) 140a), and beta (also known as CD140b). PDGF is a potent mitogen for connective tissue cells. PDGF-stimulated processes are mediated by three different PDGFs (PDGF-A,PDGF-B, and PDGF-C). PDGFRalpha binds to all three PDGFs, whereas the PDGFRbeta binds only to PDGF-B. PDGFRs alpha and beta have similar organization: an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. In mice, PDGFRalpha and PDGFRbeta are essential for normal development.
Statistics
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PSSM-Id: 409447
View PSSM: cd05861
Aligned: 3 rows
Threshold Bit Score: 178.952
Threshold Setting Gi: 129890
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #####                                                                           
129890     212 SSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLldmpYHIRSILHIPSAELEDSGTYTC 291  human
129895     215 HNISVEMEAPKTMFRAGETIAIDCIVLDNEVVDLKWTYPGKQRGVGIRNVEESKvp-yQRLVYTLTLANATTEDSGEYEC 293  African clawed frog
129892     212 SELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKvp-sIKLVYTLTVPEATVKDSGDYEC 290  human
Feature 1                          
129890     292 NVTESVNDHQDEKAINITVV 311  human
129895     294 AVIHATLDNRVVKKTNITVH 313  African clawed frog
129892     291 AARQATREVKEMKKVTISVH 310  human

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