1E0O,1EV2,1CVS,1RY7


Conserved Protein Domain Family
IgI_2_FGFR

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cd05857: IgI_2_FGFR 
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Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor. FGF receptors bind FGF signaling polypeptides. FGFs participate in multiple processes such as morphogenesis, development, and angiogenesis. FGFs bind to four FGF receptor tyrosine kinases (FGFR1, FGFR2, FGFR3, FGFR4). Receptor diversity is controlled by alternative splicing producing splice variants with different ligand binding characteristics and different expression patterns. FGFRs have an extracellular region comprised of three IG-like domains, a single transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding and specificity reside in the Ig-like domains 2 and 3, and the linker region that connects these two. FGFR activation and signaling depend on FGF-induced dimerization, a process involving cell surface heparin or heparin sulfate proteoglycans.
Statistics
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PSSM-Id: 409443
View PSSM: cd05857
Aligned: 8 rows
Threshold Bit Score: 189.679
Threshold Setting Gi: 114149298
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:FGF binding site [polypeptide binding site]
Evidence:
  • Structure:1E0O; human FGF1-FGFR2 interaction interface defined by 3.5A distance.
    View structure with Cn3D
  • Comment:The FGF1-FGFR2-heparin complex is comprised of one heparin molecule linked to two FGF1 molecules, each FGF1 molecule of which is bound to a receptor ectodomain. Shown here is one FGF1 molecule bound to the receptor ectodomain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 # # #                                                               
1E0O_B      7 PYWTNTEKMEKRLHAVPAANTVKFRCPAGgnPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 86  human
1EV2_E      8 PYWTNTEKMEKRLHAVPAANTVKFRCPAGgnPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 87  human
1CVS_C     13 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSgtPQPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV 92  human
1RY7_B    120 PYWTRPERMDKKLLAVPAANTVRFRCPAAgnPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVV 199 human
Q4H3K6     74 PRWVNEQKMQKRLHAEPAGNTVQFRCAVQgaRPITVDWYKDGEPIKKNGRLGGYKFRQRNQQISLESVIMSDRAKYMCVA 153 Ciona intestinalis
NP_990650 156 PYWTHTDKMEKRLHAVPAANTVKFRCPAMgnPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCIV 235 chicken
Q03364    145 PYWTNTEKMEKKLHAVSAANTVKLRCPARe-PHPSNEWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGIYTCIV 223 African clawed frog
Q8JG38    154 PYWTFPEKMEKKLHAVPAANTVKFRCAAAgnPKPKMRWLKNAKPFRQEDRMGGYKVRLQHWTLIMESVVPSDKGNYTCLV 233 zebrafish
Feature 1                    
1E0O_B     87 ENEYGSINHTYHLDV 101 human
1EV2_E     88 ENEYGSINHTYHLDV 102 human
1CVS_C     93 ENEYGSINHTYQLDV 107 human
1RY7_B    200 ENKFGSIRQTYTLDV 214 human
Q4H3K6    154 HNKYGSINHTYELDV 168 Ciona intestinalis
NP_990650 236 ENQYGSINHTYHLDV 250 chicken
Q03364    224 ENEHGSINHTYHLDV 238 African clawed frog
Q8JG38    234 ENQYGSIDHTYTLDV 248 zebrafish

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