Conserved Protein Domain Family
IgI_2_FGFRL1-like

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cd05856: IgI_2_FGFRL1-like 
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains
The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor like-1(FGFRL1). FGFRL1 is comprised of a signal peptide, three extracellular Ig-like modules, a transmembrane segment, and a short intracellular domain. FGFRL1 is expressed preferentially in skeletal tissues. Similar to FGF receptors, the expressed protein interacts specifically with heparin and with FGF2. FGFRL1 does not have a protein tyrosine kinase domain at its C-terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.
Statistics
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PSSM-Id: 409442
View PSSM: cd05856
Aligned: 6 rows
Threshold Bit Score: 159.255
Threshold Setting Gi: 115768335
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:FGF binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    # # #                                                               
NP_989787    141 PRFTQPAKMRRRVIARPVGSSIRLKCVASGNPRPDITWLKDNKPLmpheiGENKkkkWTLNLKNLKPEDSGKYTCRVFNK 220 chicken
CAH03196     148 PRFSQPTKMRRRVLEQPVGSSVRLKCLASGNPTPVITWWKDQSLLdn--pQQSKrpqWTLTLKNLQPQDSAKYTCHVSNA 225 zebrafish
BAD18794     117 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALtrpeaAEPRkkkWTLSLKNLRPEDSGKYTCRVSNR 196 human
NP_956670    141 PRFTQPAKMRKRVIARPVGSSVRLKCTASGNPRPDIVWLKDSRPLtpeevGEGRkkkWTLSLKNLTPEHSGKYTCHVSNR 220 zebrafish
NP_001086420 141 PRFTQPAKMRKRVIARPVGSSVRLKCIASGNPRPDITWLKDNKPLtsqeiGDNKkkkWTLNLKSLKPEDSGKYTCQVYNR 220 African clawed ...
XP_783945    176 QFSELSKMMKAQKIMKPLNSSVRLKCKASGHPRPEIVWEKDGTRMvi-teGRQSr-qFTLKLSHLKPGDSGTYMCIVFNK 253 purple urchin
Feature 1                    
NP_989787    221 VGEINATYKVEV 232 chicken
CAH03196     226 AGHINATYKVDV 237 zebrafish
BAD18794     197 AGAINATYKVDV 208 human
NP_956670    221 AGEINATYKVEV 232 zebrafish
NP_001086420 221 VGQINATYKVEV 232 African clawed frog
XP_783945    254 HGRINATYEVDV 265 purple urchin

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