1HCF


Conserved Protein Domain Family
IgI_TrkB_d5

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cd05855: IgI_TrkB_d5 
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Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the fifth domain of Trk receptor, TrkB, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors, which mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. Trks are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkB shares significant sequence homology and domain organization with TrkA and TrkC. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrKB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. In some cell systems NT-3 can activate TrkA and TrkB receptors. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. This group belongs to the I-set of IgSF domains
Statistics
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PSSM-Id: 409441
View PSSM: cd05855
Aligned: 4 rows
Threshold Bit Score: 190.835
Threshold Setting Gi: 17943177
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site [polypeptide binding site]
Evidence:
  • Structure:1HCF, human Trkb-D5 bound to neurotrophin-45, a nerve growth factor, contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      #               ##  #          
1HCF_X      4 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVtn--htEYHGCLQLDNPTHMNNGDYTLIA 81  human
AAH87462  283 PPVITFIDLPTLDHHWCIPFSVRGNPKPTLQWFHEGNVLSETDFIWSKIHEtsnntiEHHGCLQLDSPTHLNNGFYTLRA 362 African clawed frog
NP_990562 285 APNITFIESPTPDHHWCIPFTVKGNPKPTLQWFYEGAILNESEYICTKIHVin--qsEYHGCLQLDNPTHLNNGAYTLLA 362 chicken
CAM56611  336 PPTVLELYLPERSQDWCIPFVVTGNPRPDLHWYHEGKPLEEQEYIRTEIHDit--ntEYHGCLKLDTPTHIHNGIYTLVA 413 zebrafish
Feature 1                     
1HCF_X     82 KNEYGKDEKQISAHFM 97  human
AAH87462  363 ENKYGRDERSISALFM 378 African clawed frog
NP_990562 363 KNEYGEDEKRVDAHFM 378 chicken
CAM56611  414 SNEFGEDRGNVTAHFM 429 zebrafish

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