1O0V,1O0V


Conserved Protein Domain Family
IgC1_CH2_IgE

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cd05847: IgC1_CH2_IgE 
Click on image for an interactive view with Cn3D
CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin E (IgE); member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the second constant domain of the heavy chain of immunoglobulin E (IgE). The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta, and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). The different classes of antibodies vary in their heavy chains; the IgE class has the epsilon type. This domain (Cepsilon2) of IgE is in place of the flexible hinge region found in IgG.
Statistics
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PSSM-Id: 409434
View PSSM: cd05847
Aligned: 10 rows
Threshold Bit Score: 136.773
Threshold Setting Gi: 104089
Created: 21-Dec-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1O0V; human IgE-Fc chains A and B, C epsilon 2A/C epsilon 2B interface, based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Human IgE-Fc is a disulfide-linked dimer of 3 domains: C epsilon 2- C epsilon 3- C epsilon 4.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ####             #                                                           
1O0V_A        11 PTVKILQSScdggghfpptIQLLCLVSGYTPGTIQITWLEDGQVMdv-dLSTASTTQEge-lASTQSELTLSQKHWLSDR 88  human
1O0V_B        11 PTVKILQSScdggghfpptIQLLCLVSGYTPGTIQITWLEDGQVMdv-dLSTASTTQEge-lASTQSELTLSQKHWLSDR 88  human
AAX73306     106 PTVKLFHSScnplgdthttIQLLCLISGYVPGDMEVIWLVDGQKAtnmfPYTAPGTQEgn-vTSTHSELNITQGEWVSQK 184 giant panda
CAA30161     178 PEVQVLHPSsctps-qsesVELLCLVTGFSPASAEVEWLVDGVGGll-vASQSPAVRSgs-tYSLSSRVNVSGTDWREGK 254 chicken
NP_001083154 253 PTVEILQGPcas----sesVELLCLITGYAPSEIKVQWLLNGQVTeispSNSKPCKEEnd-tFSSRSKVSVPKEDWNSGD 327 African clawed ...
B46529       250 PEVQVLHSSvcstl-gddsVELLCVITGFSPPPVEVEWLVDGAPAhlvaTMTRPQREAgsktYMATSQTNVSREDWKAGK 328 mallard
ABG72685     108 PDVRLLHSScnrns-ddatIQLVCLISGFYPSTVTVNWLVDGQSGmlpaHTEDPKKDAsgdtFSTTSTANITQLEWKEGK 186 Eublepharis mac...
S31436       111 PSVQVLQSScadtd-gngsIELVCLISGYTPDNIQVRWLVNDKMApiqgQTSPPQKDGqg-tFSTTSQINVTKSDWASGD 188 axolotl
S38864       233 SSVFIFPPKpkdvl-trstIQLYCFIYGHILNDVSVSWLMDDREItdtlAQTVLIKEEgk-lASTCSKLNITEQQWMSES 310 house mouse
S04845       240 PTVEILQGPcas----sksVELLCLITGYAPSEIKVHWLLNGQVTnispSNSKPCKEEng-tFSSRSKVSVPKEDWNSED 314 African clawed ...
Feature 1                         ### 
1O0V_A        89 TYTCQVTYqg--hTFEDSTKK 107 human
1O0V_B        89 TYTCQVTYqg--hTFEDSTKK 107 human
AAX73306     185 TYTCQVVYqg--lTFNANARK 203 giant panda
CAA30161     255 SYSCRVRHpatntVVEDHVKG 275 chicken
NP_001083154 328 SYTCKVTHpashtKTEASTKK 348 African clawed frog
B46529       329 AFTCRVKHpatggTAQGHARF 349 mallard
ABG72685     187 TYTCQVIHqg--sTVERNATK 205 Eublepharis macularius
S31436       189 KYTCKVEHpatssRAEDTIHN 209 axolotl
S38864       311 TFTCKVTSqg--vDYLAHTRR 329 house mouse
S04845       315 SYTCKVTHpashtKTEASTKK 335 African clawed frog

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