Conserved Protein Domain Family
BS69_related

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cd05841: BS69_related 
The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND domains. The specific role of the PWWP domain within BS69 is not clearly identified, but BS69 functions in chromatin remodeling, consistent with other PWWP-containing proteins. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99902
View PSSM: cd05841
Aligned: 12 rows
Threshold Bit Score: 140.231
Threshold Setting Gi: 45552014
Created: 16-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         #  #  #                  #   # #                                
Q15326        232 WFCYPCIPNHELVWAKMKGFGFWPAKVMQked---nqVDVRFFGhHHQRAWIPSENIQDITvni--hrlHVKRSMGWKKA 306  human
NP_001096471  272 WFCYPCIPNHELVWAKMKGFGFWPAKVMQked---nqVDVRFFGhHHQRAWIPSDNIQEITvnv--hqlHVKRSMGWKKA 346  western clawe...
Q9ULU4        269 WFCEPCSNPHPLVWAKLKGFPFWPAKALRdkd---gqVDARFFG-QHDRAWVPINNCYLMSkei--pfsVKKTKSIFNSA 342  human
NP_733441     530 WFVKVCRHPHLLLWAKLKGFPYWPAKAMGssn--stlVNVRFFG-KHDRAFVPVKDCFLYSaqnpntqtSRRSARDLAEC 606  fruit fly
XP_418557     272 WFCYPCIPNHELVWAKMKGFGFWPAKVMQked---nqVDVRFFGhHHQRAWIPSENIQDITvni--hrlHVKRSMGWKKA 346  chicken
XP_393096     281 WFCIPCNPPHQLVYAKQKGYPYWPAKVMQvng---niYDVRFFGgHHMRANIEKMFIRPITtsl--qslQIKRSTAWNRA 355  honey bee
XP_786258      21 WFSEVCTKPHPLVWAKLHGFPFWPAKAMKeed---glLEARFFG-QHDRAMIPVHNCFQYStkip-fpaSKKRLTGLNSS 95   purple urchin
NP_001071051  291 WFCYPCSPNHELVWARMKGFGYWPAKVMQreg---nqVDVRFFGhQHQRAWIPSDNIQDITvsv--qqlQVKRSSGWKKA 365  zebrafish
XP_417384     377 WFCEPCSNPHPLVWAKLKGFPFWPAKALRdkd---gqVDARFFG-QHDRAWVPINNCYLMSkei--pfsVKKTKSIFNSA 450  chicken
XP_312072     290 WFARPCRTRHELVFAKQSRFQYWPAKVVRvvn---nlYDVRFFGgNHPRALIDAGWVKPIDtelg-tlgVKDKHGGFQLA 365  Anopheles gam...
AAF58494      366 WFAKPCLQRHELVFAKQVGSPPWPAKVMSvskrqpikYDVRFFGgTHSRALISERDITPIEsdiq-shiKPRNSRALSAA 444  fruit fly
XP_001651372  265 WFARPCNTRHELVFAKHKGYQYWPAKVIRvvn---nkYDVRFFGdKHSRAVVDTAFVKPIDsdlv-qlkINPKKPGFQKS 340  yellow fever ...
Feature 1                
Q15326        307 CDELELH 313  human
NP_001096471  347 CDELDLH 353  western clawed frog
Q9ULU4        343 MQEMEVY 349  human
NP_733441     607 IREVEIH 613  fruit fly
XP_418557     347 CDELELH 353  chicken
XP_393096     356 FDELKHH 362  honey bee
XP_786258      96 IKEAELH 102  purple urchin
NP_001071051  366 CDELELH 372  zebrafish
XP_417384     451 MQEMEVY 457  chicken
XP_312072     366 MKEMLKY 372  Anopheles gambiae str. PEST
AAF58494      445 IKELQCH 451  fruit fly
XP_001651372  341 MEELHKH 347  yellow fever mosquito

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