1H3Z


Conserved Protein Domain Family
SPBC215_ISWI_like

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cd05840: SPBC215_ISWI_like 
Click on image for an interactive view with Cn3D
The PWWP domain is a component of the S. pombe hypothetical protein SPBC215, as well as ISWI complex protein 4. The ISWI (imitation switch) proteins are ATPases responsible for chromatin remodeling in eukaryotes, and SPBC215 is proposed to also bind chromatin. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99901
View PSSM: cd05840
Aligned: 16 rows
Threshold Bit Score: 116.263
Threshold Setting Gi: 145614654
Created: 28-Nov-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #  #  #                                                 #  # #        
1H3Z_A         7 YKPGMRVLTKMSGFPWWPSMVVTeskmtsvark--------------------skpkragtfYPVIFFPNKEYLWTGSDS 66  fission yeast
XP_720317      4 YQPTSIVLAKVKGYPAWPAMVLDesllpehisnkkpksktnpptsissptpqspskkkpsiiVPVRFFSDDTYIWINTND 83  Candida albican...
XP_452009      6 LVTGDLVLCTVGSYEPWPAVVVPqrilsksvl----------------------kakenvgqVAVAFFNDSTYYWTKPKQ 63  Kluyveromyces l...
NP_984597      6 IRTGDRVLCKVGDFPPWPAVVVPqrflsklvy----------------------sgkrsksyVCVAFFNDDSYYWKEPRH 63  Ashbya gossypii...
XP_501369    188 FPPGTIVLAKVKGFPAWPGMVVPedvlpssvln--------------------akprknrqmWPVRFFIDTTHTWAYRND 247 Yarrowia lipoly...
Q06188         5 IRTGDLVLCKVGSFPPWPAVVFPqrllrndv-----------------------yrkrksncVAVCFFNDPTYYWEQPSR 61  baker's yeast
O59676        50 LNFGDRILVKAPGYPWWPALLLRrketkdsln----------------------tnssfnvlYKVLFFPDFNFAWVKRNS 107 fission yeast
XP_761331     20 FQVDDVVLAKVRGFPAWPGIVMAdenvpsavlk-------------------erpvakhrdlYTIRFFPAADYHWAFSKD 80  Ustilago maydis...
XP_572999     34 FDIGDIVLARLRGYPPWPARIANpetlprnvlk--------------------trpgknpnlYCCQFFPAGDFSWLQNKD 93  Cryptococcus ne...
XP_001248414 147 AQPGEYYFARLRSWPPWPAIICDeemlpqsllatrpittkqs-dgtytehfkdgakrvhertFPVMFLHTNEFAWIPNTD 225 Coccidioides im...
Feature 1                                            
1H3Z_A        67 LTPLTsEAISQFLEKPk---pKTASLIKAYKMAQST 99  fission yeast
XP_720317     84 LKPLTkQMIQDYFSTSskkrkIDNLLQTAYELANDP 119 Candida albicans SC5314
XP_452009     64 LKLLTeENIEAWIKSPpk--rSSKELKKAYQFASDY 97  Kluyveromyces lactis NRRL Y-1140
NP_984597     64 LTLLTdKMCTDWMKNSk---sKDEALIGAYQQAIEY 96  Ashbya gossypii ATCC 10895
XP_501369    248 LKPLGvEEAANFLKSAsr-grKDKSLHAAYKVASEP 282 Yarrowia lipolytica CLIB122
Q06188        62 LKELDqDSIHNFILEHsk-naNQRELVNAYKEAKNF 96  baker's yeast
O59676       108 VKPLLdSEIAKFLGSSk---rKSKELIEAYEASKTP 140 fission yeast
XP_761331     81 LELLNkDKIDSFLAGPn---rKKGDLRQAYEIARDP 113 Ustilago maydis 521
XP_572999     94 IKALSaSDISSFLAQPhr--kSSGGLREAYQTAQDP 127 Cryptococcus neoformans var. neoformans JEC21
XP_001248414 226 LVPLD-PEQCKNPEKA-----KGKGLLAAYQVASEG 255 Coccidioides immitis RS

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