Conserved Protein Domain Family
BR140_related

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cd05839: BR140_related 
The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, BR140 is disrupted by chromosomal translocations, similar to translocations of WHSC1 in lymphoid multiple myeloma. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99900
View PSSM: cd05839
Aligned: 7 rows
Threshold Bit Score: 156.513
Threshold Setting Gi: 71023893
Created: 27-Nov-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #  #  #                                               #   # #         
XP_001599557  862 LTALQLVWAKCRGYPWYPALIIDPNTPrgtvhkgvpi-----psppddvlaLASNYKDRVYLVLFFDtKRTWQWLPGEKL 936  jewel wasp
XP_419262    1043 LEPLELVWAKCRGYPSYPALIIDPKMPregllhngvpipvppmdvlklgeqRQTEAGEKLFLVLFFDnKRTWQWLPRDKV 1122 chicken
P55201       1083 LDALDLVWAKCRGYPSYPALIIDPKMPregmfhhgvpipvpplevlklgeqMTQEAREHLYLVLFFDnKRTWQWLPRTKL 1162 human
XP_001190303 1136 LNPLDMVWAKCRGYPSYPALIIDPKMPrsgtfhngvp----ipvpttevlnQRLNLDDLLYLVLFFDnKRTWQWLPRTKL 1211 purple urchin
XP_001342944  464 PEPLDLVWAKSRGYPSYPALIIDPDMPqdgllhngvpipvppldvlrlgeqRQEEAGERLFLVLFFDnKRTWQWLSKDKV 543  zebrafish
XP_774811     990 YPPGTLVWAKIHTFPFFPAEIVDLIDDrdevpdavl-------keetasraAAKNVNKDVWLVRFFDaRSSYGWITGDRL 1062 Cryptococcus ...
XP_762176    1130 PAAGTKVWAKVETFPHFPAIVIRDKTDlpg------------------emlRTQPEDESMVAVRFFGkQTSYGWITPLKL 1191 Ustilago mayd...
Feature 1                                                      
XP_001599557  937 EPLGVsqelddg---------kliesrKPTDRKAVKKAYQDALLY 972  jewel wasp
XP_419262    1123 YPLGVddtvdkl---------kmmegrKTSIRKSVQVAYDRAMIH 1158 chicken
P55201       1163 VPLGVnqdldke---------kmlegrKSNIRKSVQIAYHRALQH 1198 human
XP_001190303 1212 EPLGVdsgldnv---------klmegrKSTVRKNVQIAYDRAVHH 1247 purple urchin
XP_001342944  544 IPLGVddttdkl---------rimegkKTSIRKSVQVAYDRAMKH 579  zebrafish
XP_774811    1063 DELGEdenvdamylagkdregkskgfkTPSLKRACRKGYRDALNS 1107 Cryptococcus neoformans var. neoformans B-3501A
XP_762176    1192 APLLMdesedek---------ylklaaKKGKTKQVRDAYEDAKSY 1227 Ustilago maydis 521

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