3LYI,4Z02,3PFS,2X4W


Conserved Protein Domain Family
PWWP_BRPF
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cd05839: PWWP_BRPF 
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PWWP domain found in the bromodomain and PHD finger-containing (BRPF) protein family
The BRPF family of proteins includes BRPF1, BRD1/BRPF2, and BRPF3. They are scaffold proteins that form monocytic leukemic zinc-finger protein (MOZ)/MOZ-related factor (MORF) H3 histone acetyltransferase (HAT) complexes with other regulatory subunits, such as inhibitor of growth 5 (ING5) and Esa1-associated factor 6 ortholog (EAF6). BRPF proteins have multiple domains, including a plant homeodomain (PHD) zinc finger followed by a non-canonical extended PHD (ePHD) finger, C2HC5HC2H, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. The PHD finger binds to lysine 4 of histone H3 (K4H3), the bromodomain interacts with acetylated lysines on N-terminal tails of histones and other proteins, and the PWWP domain shows histone-binding and chromatin association properties.
Links
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Statistics
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PSSM-Id: 438964
Aligned: 68 rows
Threshold Bit Score: 95.0266
Created: 27-Nov-2007
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Structure:2X4W; Homo sapiens BRPF1 binds H3K36me3 peptide in an aromatic cage; contacts at 4A
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #                   ###                                ## # ####
3LYI_A          4 LEPLKVVWAKCsGYPSYPALIIDPKMPRvpghhngVTIPAPpldvlkige--------hmqtksdekLFLVLFFDnKRSW 75   human
2X4W_A         10 LDALDLVWAKCrGYPSYPALIIDPKMPRegmfhhgVPIPVPplevlklge--------qmtqearehLYLVLFFDnKRTW 81   human
XP_025379544 1045 FEVGTTCWAKMpGYPYYPAEIWSQTASS-------VPKNVEadrpk----------------assesVELVRFFDaQRSF 1101 Acaromyces in...
XP_013245717 1335 LPPGRLVWARFeKWPYFPSEVFAEDSDQ-------VPERVLehkp-------------------sgtVTLVRFFDaKQSW 1388 Tilletiaria a...
XP_025360031  930 SPAGTLVWAKYgSHPFYPAEVFSEKSAL-------VPPTVLsarpaps------------tiptgqrVHLVRFFDrARSW 990  Jaminaea rosea
PWN51675     1504 FEPGTLVWAKMtGFPFFPAAVFDEEETEs------IPKSVLeekrnethhqeenassdhhhqqppskLHLVQFFDkAKSW 1577 Violaceomyces...
CUA70683     1010 YETGTLVWAKQqGFPYYPAAVHEPNDPM-------VPHNILgledvirr-----------klkatgvMYPVQFYDkQRTW 1071 Rhizoctonia s...
KAB5594486    917 YEAGTLVWARQaGFPWYPAVVYEPPDEV-------IPPKILaheheihr-----------klkytgrLYLVQFYDkQRTW 978  Ceratobasidiu...
OAV99833     1747 IEDGTLVWAKVhGHPWFPAEVGLPDDPA-------VPQSMLdkqptd---------------gkieqYVLVMFFDrQRSW 1804 Puccinia trit...
KZV65045     1602 IPENTLVWAKMgSYPYYPARIINPDSDV-------VPNSVHrsyrttr------------kkrgqskWQLVQFFDeGNDW 1662 Peniophora sp...

Feature 1         #                                                          
3LYI_A         76 QWLPKsKMVPLGId-ETIDKLKMMEGRns--------------siRKAVRIAFDRAMNH 119  human
2X4W_A         82 QWLPRtKLVPLGVn-QDLDKEKMLEGRks--------------niRKSVQIAYHRALQH 125  human
XP_025379544 1102 GWIGTsKLELMFEd-AKLDEKMLGTDNmaghgdrrkssstaskriREEVASAYAAAKAE 1159 Acaromyces ingoldii
XP_013245717 1389 AWVTLdRIRFAFEd-LAQDEKLKHPADkr---------------sRKSVREAYRRAEQA 1431 Tilletiaria anomala UBC 951
XP_025360031  991 GWAST-GLCRLLLedEELDSGMVSAVKar---------------qREAIRKAMWRAGRA 1033 Jaminaea rosea
PWN51675     1578 KWLRAnKLRYMFEd-QELDSSLLKSKDirt------------phmRSSIRLAYANAKAT 1623 Violaceomyces palustris
CUA70683     1072 TWVPLnKLILLGEn-EAIDQKHLHPTSksggrs------gnksadRKALKEAYRLALED 1123 Rhizoctonia solani
KAB5594486    979 TWVPLsRLTMLGEd-KEIDQKYLHPTGkha-------------ssKKDVQTAYSMALQE 1023 Ceratobasidium theobromae
OAV99833     1805 QWVQRrNTRLLGEs-DELDALLSSEAYvsn------------ktqLEEIQNGCAFARAN 1850 Puccinia triticina 1-1 BBBD Race 1
KZV65045     1663 GTIHPvRLRYMFRf-PEIDAAMLKDAKgi---------------hRDSVHKAFERVSSM 1705 Peniophora sp. CONT

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