2DAQ


Conserved Protein Domain Family
WHSC1_related

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cd05838: WHSC1_related 
Click on image for an interactive view with Cn3D
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as plasmacytoma. WHCS1 proteins typically contain two copies of the PWWP domain. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99899
View PSSM: cd05838
Aligned: 13 rows
Threshold Bit Score: 135.522
Threshold Setting Gi: 115435314
Created: 27-Nov-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #   #  #                            #        # #                      
2DAQ_A          9 LHYKQIVWVKLGn-YRWWPAEICNPRSVPlnIQGLKHDl-GDFPVFFF------GSHDYYWVHQGRVFPYVEGDKSFAEG 80   human
XP_001635219  193 LLYGDIVWVKLGm-YRWWPAMICNPRDVPtnIQSMRHQp-GEFPVMFL------GSHDFYWIHKGRVFSYQDGDKGTESG 264  starlet sea a...
XP_424390     907 LRYKQIVWVKLGn-YRWWPAEICNPRSVPlnIQGLKHDi-GDFPVFFF------GSHDYYWVHQGRVFPYVEGDKSFAEG 978  chicken
XP_001600694  803 PLYGEVVWVKLGt-YRWWPSVICYPQEIPtnIATRPHKa-GEFCVMFL------GTRDYYWIHRGKAFLYQDGDANTKVI 874  jewel wasp
XP_001654536 1033 PLYNEIVWARYGl-FRFWPAITVPPPKVPenIEQKPHNp-WDICIRFF------GTNDYVWINRRRIYLYQEGDSDTNVD 1104 yellow fever ...
NP_001042415  272 FVLGDVVWARSGkkCPAWPALVIDPLLHAp-RVVLNSCipGALCVMFFgys-nsGLRDYGWVKQGLIFPFVEYLDRFKGQ 349  Japanese rice
ABC88477      875 PKYRDVIWVKLGn-YRWWPAEIRHPKNIPtnIQHLRHEi-GEFPVFFF------GSKDYFWTHQGRVFPYMEGDRGSKYQ 946  zebrafish
XP_973711    1229 PLYDEIVWVKLGs-FRWWPAVILFPNEVPdnVKNIPHSk-GEFVVKFY------GTYDHYWVGRGRTFLFQEGDRGHSGS 1300 red flour beetle
XP_001191608   39 PRYGDIIWVKLGn-YRWWPGRVCNPKDVPqnIQDKTHIv-GEFPVQFF------GSNDYFWTHQGRVFEYQEGDKGSRET 110  purple urchin
XP_316738     585 PLYNEIVIAKMGs-FRWWPALTLPPSEIPqnMLQLRHKp-SDICVKFF------NTHDMSWLNRKRMYLYQREDSESLDG 656  Anopheles gam...
Q8MT36       1047 PLYGEIVWAKFNn-FRWWPAIILPPTEVPsnILKKAHGe-NDFVVRFF------GTHDHGWISRRRVYLYIEGDTGDGHK 1118 fruit fly
Q9SUE7        205 FYSGDLVWAKSGrnEPFWPAIVIDPMTQAp-ELVLRSCipDAACVVFFghsgneNERDYAWVRRGMIFPFVDYVARFQEQ 283  thale cress
Q9M364        187 FTVGDLVWAKCGkrFPAWPAVVIDPISQAp-DGVLKHCvpGAICVMFFgyskdgTQRDYAWVRQGMVYPFTEFMDKFQDQ 265  thale cress
Feature 1                                  
2DAQ_A         81 qts---inKTFKKALEEAAKRFQEL 102  human
XP_001635219  265 nnk--ylaKVFKKALVEAKEKYDEW 287  starlet sea anemone
XP_424390     979 qts---inKTFKKALEEAAKRFQEL 1000 chicken
XP_001600694  875 gsk--kveESYRKALQEAKLFHERL 897  jewel wasp
XP_001654536 1105 kkt--tlaKRYGLALEEAKTVHGML 1127 yellow fever mosquito
NP_001042415  350 tlyk-ikaSRFREAIEEAFLAERGL 373  Japanese rice
ABC88477      947 qtg---igKVFKNALLDAETRFKEI 968  zebrafish
XP_973711    1301 vkk--rvdNAFVKAIEEAAAAHELK 1323 red flour beetle
XP_001191608  111 ansk-rlaAVFSLALKEASQKYKLW 134  purple urchin
XP_316738     657 sqsgssmdKRYRSAMTEASKIFKIL 681  Anopheles gambiae str. PEST
Q8MT36       1119 tks--qlfRNYTTGVEEASRFLPII 1141 fruit fly
Q9SUE7        284 pelqgckpGNFQMALEEAFLADQGF 308  thale cress
Q9M364        266 tnlfnykaSEFNKALEEAVLAENGN 290  thale cress

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