2GFU


Conserved Protein Domain Family
MSH6_like

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cd05837: MSH6_like 
Click on image for an interactive view with Cn3D
The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been linked to increased cancer susceptibility, particularly in hereditary nonpolyposis colorectal cancer in humans. The role of the PWWP domain in MSH6 is not clear; MSH6 orthologs found in S. cerevisiae, Caenorhabditis elegans and Arabidopsis thaliana lack the PWWP domain. Histone methyltransferases (HMTases) induce the posttranslational methylation of lysine residues in histones and play a role in apoptosis. In the HMTase Whistle, the PWWP domain is necessary for HMTase activity. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99898
View PSSM: cd05837
Aligned: 14 rows
Threshold Bit Score: 144.451
Threshold Setting Gi: 51702190
Created: 27-Nov-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #  #  #                                     #   # #                 
2GFU_A         21 SDFSPGDLVWAKMEGYPWWPSLVYNHPfdgtfi-----------rekgkSVRVHVQFFDDSPTRGWVSKRLLKPytgsks 89   human
XP_419359     203 GVYSPGDLVWAKMEGYPWWPCLIYNHPtegtiv-----------rgkgsSARIHVQFFDVSPTRGWVSIKYLRPykgssd 271  chicken
XP_797647      60 QTFAPGDLVWARLEGYPWWPSLVCNHPtlekct-----------kkegrKGLVHVQFFDDPPSRAWISDKFIEGyngsra 128  purple urchin
NP_001089247   77 CDFNPGDLVWAKMLGHPWWPSLVYNHPkegthl-----------rgkgkSLHVHVQFFDDSPTRGWTGAKYIKPfsgsta 145  African clawe...
XP_001603633   72 STWELGTLAWARMSIYPFWPCMITHDPnspmiyqk------vqtvgkskTLMIHVHFFNDNGRHSWIPSHHMLHfdngie 145  jewel wasp
Q8MT36        391 PTYQVGDLFWGKVFSYCFWPCMVCPDPlgqivgnmpshpqrssldnanvPIQVHVRFFADNGRRNWIKPENLLTfaglka 470  fruit fly
XP_424390     266 IKFQVGDLVWSKVGTYPWWPCMVSCDPqldvht----------kintrgAREYHVQFFSNQPERAWVHEKRVREykghkq 335  chicken
Q9H0M4        313 ASYIPGSIIWAKQYGYPWWPGMIESDPdlgeyflf-------tshldslPSKYHVTFFGETVSRAWIPVNMLKNfqels- 384  human
XP_785219     332 CEWLVGDLVWSKVSGHPWWPCMVAYDPnlgiytrm-------kgsigktYRMYHVQFFGEVPERGWVSGSSMKKfsgrdq 404  purple urchin
Q9BZ95        266 VKFQVGDLVWSKVGTYPWWPCMVSSDPqlevht----------kintrgAREYHVQFFSNQPERAWVHEKRVREykghkq 335  human
Feature 1                                                              
2GFU_A         90 ke--------------aqkgghfySAKPEILRAMQRADEALnkdkIKRLELAV 128  human
XP_419359     272 re--------------vlkggmfySMKPEIKKAMELADDAMskdkTKRLELAV 310  chicken
XP_797647     129 ke--------------cqfgckfhTTKPDVRRGMDQADEALkkdrEERMELVV 167  purple urchin
NP_001089247  146 ae--------------tqkggmffSTKPEIKKAMKMADDAVtldkQKRLELAV 184  African clawed frog
XP_001603633  146 dfrkraslvtdiirkkepkfaaalTIKPNIYGTWQKAVAEAmd-vLYEIDMSP 197  jewel wasp
Q8MT36        471 fd--------------dmreelriKHGPKSAKYRQMVPKRTkv-vIWRQAIEE 508  fruit fly
XP_424390     336 yeqllae----aakqasnhsekqkIRKPRPQRERAQWDIGIah-aEKALKMTR 383  chicken
Q9H0M4        385 --------------------lelsVMKKRRNDCSQKLGVALmm-aQEAEQISI 416  human
XP_785219     405 ydslveemvskvrkaersrmlsklAVKPCRRNAWDAAISEC----EKALPMSR 453  purple urchin
Q9BZ95        336 yeellae----atkqasnhsekqkIRKPRPQRERAQWDIGIah-aEKALKMTR 383  human

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