Conserved Protein Domain Family
N_Pac_NP60

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cd05836: N_Pac_NP60 
The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the nucleus. In addition to the PWWP domain, NP60 also contains an AT-hook and a C-terminal NAD-binding domain. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99897
View PSSM: cd05836
Aligned: 8 rows
Threshold Bit Score: 149.142
Threshold Setting Gi: 91081069
Created: 1-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #  #  #                          #  # #                               
AAH47223       6 LRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPrgk---kcFFVKFFGTEDHAWIKVEQLKPYHAHKEEMi-KINKGKRFQQ 81  human
NP_001025665   6 LRQGDLVWGKLGRYPPWPGKIVNPPKDLKKPrgk---kcLFVKFFGTEDHAWIKVEQLKPYHAHKEEMi-KANKGKRFQQ 81  western clawed ...
XP_001356318  20 YKPKDLIWAKMKGFTPWPGMIVEPPLDLLTQqrr--antKCVFFFGSRNFAWIEENNIKPFEGPWKEElaKVSKPAAFRH 97  Drosophila pseu...
XP_975443      5 PQIGDLVWAKMKSYSPWPARIVKPGPNSKKQskk---gsHWVYFFGSNNYAWIETPNIKPYEKFKEKFs-GLCKSTPFKD 80  red flour beetle
AAH85567       6 LRIGDLVWGKLGRYPPWPGKVVSPPKDLKKPrgk---kcFFVKFFGTEDHAWIKVEQLKPYHPHKEEMi-KVNKGKRFQQ 81  zebrafish
NP_001006572   6 LRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPrgk---kcFFVKFFGTEDHAWIKVEQLKPYHLHKEEMi-KINKGKRFQQ 81  chicken
XP_001600452   5 FKLGDLVWAKMKGFSPWPGRVSTPLANMKKPanpkkgpiYCIFFFGSENYGWIDESNIKPYQEHKEACr-KLCKSEGFKK 83  jewel wasp
XP_784673     44 FDLGDLVWAKMSSFPAWPGRIVKQWKNVKKPagk--kavRFVFFFGTEDHAWVKEESLKHYHEHKATLs-KAGKGAKFTK 120 purple urchin
Feature 1                 
AAH47223      82 AVDAVEEFL 90  human
NP_001025665  82 AVDAVEEFL 90  western clawed frog
XP_001356318  98 AMADIDKYI 106 Drosophila pseudoobscura
XP_975443     81 AVDDIEDYI 89  red flour beetle
AAH85567      82 AVDAVEEYL 90  zebrafish
NP_001006572  82 AVDAVEEFL 90  chicken
XP_001600452  84 ACDAIENFI 92  jewel wasp
XP_784673    121 AIDAIEEAI 129 purple urchin

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