Conserved Protein Domain Family

cd05835: Dnmt3b_related 
Click on image for an interactive view with Cn3D
The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in the inactivation of tumor suppressor genes. In addition, a point mutation in the PWWP domain of Dnmt3b has been identified in patients with ICF syndrome (immunodeficiency, centromeric instability, and facial anomalies), a rare autosomal recessive disorder characterized by hypomethylation of classical satellite DNA. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
PSSM-Id: 99896
Aligned: 14 rows
Threshold Bit Score: 94.358
Threshold Setting Gi: 50401183
Created: 27-Nov-2007
Updated: 2-Oct-2020
Aligned Rows:
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1                   #  #  #                            #  # #                             
1KHC_A         12 FGIGDLVWGKIKGFSWWPAMVVSwkatskr-----qampgmRWVQWFgDGKFSEISADKLVAlglfsqhfnlatfnklVS 86   house mouse
XP_414485     654 ICVGDIVWAKIYGFPWWPARILTitvsrkdn---gllvrqeACISWFgSPTTSILALSQLSPflenfqs--rfnkkrkGL 728  chicken
CAG10168      564 VAVGDIVWGKIHGFPWWPARVLSisgtrkqettsceaqwpqAKVAWFgSPTTSQLSVAKLSPfrelfrs--rfnrkkkGM 641  Tetraodon nig...
Q6NUJ5        488 VAVGDIVWGKIHGFPWWPARVLDislgqked---gepswreAKVSWFgSPTTSFLSISKLSPfseffkl--rfnrkkkGM 562  human
XP_787412     855 IFRGQLVFGKMKGFCWWPGRIVHhydrsir----eppppltRWVQWFgDDKYSLLSLGQIAGledfpdyfsvsafqkwGL 930  purple urchin
NP_001018312  835 FAVGELVWGKVKDFSLWPGLVVPwkgri--------vpvsmRRVEWFgDGMFSEIHTDGLLPfgafsknfcsksyeglPT 906  zebrafish
XP_395213     568 MDVGDVVWGKIHGFPWWPGKVLSitvscked---gtssgpqAHVAWYgSSTSSLMSCDQLSPfletfkt--rynkkkrGP 642  honey bee
XP_001624451  440 INEGSIIWGKVHGHPWWPGRVMAitevvdd----qggvdtfAHVTWFgSNTSSEMPVQELQDfepnfrr--rykkdkkGC 513  starlet sea a...
XP_796495     461 VCVGDIIWGKITGFPWWPGRIVQiivtrsne---ggitlqeAQITWFaSRSISFMPLTKLPPflgefkk--hydkkrkGL 535  purple urchin
NP_001018315  628 YIVGEMVWGPLEGFGLWPGLVQSwdsrk--------pcgsmRKVFFFgNSMQSEIQADDLTPffsfakcfssnsfatvAT 699  zebrafish
Feature 1                     
1KHC_A         87 YRKAMYHTLEKA 98   house mouse
XP_414485     729 YRKAVTEAAKAA 740  chicken
CAG10168      642 YRRAILEAAKAV 653  Tetraodon nigroviridis
Q6NUJ5        563 YRKAITEAANAA 574  human
XP_787412     931 YQKACYEALNVA 942  purple urchin
NP_001018312  907 YKNAIYQILELA 918  zebrafish
XP_395213     643 YKEAIRQAQNEA 654  honey bee
XP_001624451  514 YRRAVRQAQETL 525  starlet sea anemone
XP_796495     536 YKEAISQATKAA 547  purple urchin
NP_001018315  700 YKDAIFNSLQVA 711  zebrafish

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