1N27,2B8A


Conserved Protein Domain Family
HDGF_related

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cd05834: HDGF_related 
Click on image for an interactive view with Cn3D
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, HPR2, HPR3, HPR4, respectively) and lens epithelium-derived growth factor, LEDGF. Members of the HDGF family have been linked to human diseases, and HDGF is a prognostic factor in several types of cancer. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99895
View PSSM: cd05834
Aligned: 17 rows
Threshold Bit Score: 105.83
Threshold Setting Gi: 125774903
Created: 27-Nov-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Possible chromatin binding property is supported by its charasteristic electrostatic charge distribution. Upon binding, the charged surfaces may form nonspecific contacts with the nucleic acid on the basic side and contact the core histone molecules along the acidic surface.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #  #  #                      #  # #                                 
1N27_A          7 GEYKAGDLVFAKMKGYPHWPARIDElpegavkppaNKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGks---------nK 77   house mouse
CAF87492        7 DRLKAGDLVFAKMKGFPYWPARVCKsea----gykKRVPVFFFGTHQIGHLPPRNIVPYTGNKLKYGgg---------tF 73   Tetraodon nig...
AAV25878       16 GKLILGDLVLARVKGFPAWPAKVSRpeewdrapdpKKYFVQFFGTQEIAFVAPPDIQPFTSESKSKLlarc-----qgkT 90   Brassica oler...
XP_001357642    8 KSFSINDLVFAKVKGYPAWPAKITKyi-------nKKYNVYFYGTGETANIKIEDLFPYVENKEKFAtdk-------nmK 73   Drosophila ps...
XP_966475       5 RSFKEGDKVFAKIKGYPAWPAVILAks-------gKKFNVQFYGTGETGFIKPEDIFYYLKNKEQMVkg---------sK 68   red flour beetle
NP_491732      11 HNFQPGDLIWAKMKGFPPWPAKVLErsed---apaRRIPVMFFGTLETSFMKPNDLSDYLPNRLIHEip---------rK 78   nematode
NP_001060753   16 TQPQLGDLVLAKVKGYPPWPAKVSKpedwdqmpvpRKVFVVFFGTREIAHIALPDLQPFTENAKSEVmdrsrnkqcpkkY 95   Japanese rice
NP_001060497   21 AQWKVGDLVLAKMKGFPAWPAMISEpekwglssakKKLLVYFYGTKQIAFCNYTDLEAFTEEKRKSLlak------rhgK 94   Japanese rice
XP_624711       6 KKFFAGDKVFAKVRGYPPWPAKVEKvidp--nsknSKYSVYFYGTGETAVCKVEELYTYIENKAKFGkp---------lR 74   honey bee
XP_001602080    6 KRFSVGERVFAKVRGYPPWPAKIESitdp--tskqAKYHVSFFGTKEIGTCKIEDLLVYADNKDKLSks---------vR 74   jewel wasp
Feature 1                       
1N27_A         78 RKGFNEGLWEIENS 91   house mouse
CAF87492       74 FKGFAEGMWEIQNS 87   Tetraodon nigroviridis
AAV25878       91 VKYFAQAVTEICTE 104  Brassica oleracea
XP_001357642   74 RAKFSEAMDQIESA 87   Drosophila pseudoobscura
XP_966475      69 KKEFKDAVEQIEKA 82   red flour beetle
NP_491732      79 QKDFNKAVQEIRKA 92   nematode
NP_001060753   96 IDSFAEAVVEICKA 109  Japanese rice
NP_001060497   95 GADFVRAVKEIVEI 108  Japanese rice
XP_624711      75 RKFFHEGLVQLEQE 88   honey bee
XP_001602080   75 RKYFHEGIQELEED 88   jewel wasp

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