Conserved Protein Domain Family
Ribosomal_P2

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cd05833: Ribosomal_P2 
Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins P1, P0, L11, and 28S rRNA. P1 and P2 are the only proteins in the ribosome to occur as multimers, always appearing as sets of heterodimers. Recent data indicate that eukaryotes have four copies (two heterodimers), while most archaeal species contain six copies of L12p (three homodimers). Bacteria may have four or six copies of L7/L12 (two or three homodimers) depending on the species. Experiments using S. cerevisiae P1 and P2 indicate that P1 proteins are positioned more internally with limited reactivity in the C-terminal domains, while P2 proteins seem to be more externally located and are more likely to interact with other cellular components. In lower eukaryotes, P1 and P2 are further subdivided into P1A, P1B, P2A, and P2B, which form P1A/P2B and P1B/P2A heterodimers. Some plants have a third P-protein, called P3, which is not homologous to P1 and P2. In humans, P1 and P2 are strongly autoimmunogenic. They play a significant role in the etiology and pathogenesis of systemic lupus erythema (SLE). In addition, the ribosome-inactivating protein trichosanthin (TCS) interacts with human P0, P1, and P2, with its primary binding site in the C-terminal region of P2. TCS inactivates the ribosome by depurinating a specific adenine in the sarcin-ricin loop of 28S rRNA.
Statistics
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PSSM-Id: 100111
View PSSM: cd05833
Aligned: 53 rows
Threshold Bit Score: 61.5105
Threshold Setting Gi: 71744668
Created: 2-Aug-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P17478         1 MKYLAAYLLLTVGGKqSPSASDieSVLSTVGIEAEAERVESLIseLNGKNIEELIAAGNEKLstvp---------sagaV 71  Schizosaccharom...
XP_001756207   1 MKVVAAYLLCLLGGNaSPSAKDieAVLGSVGAEADSARVRLLLkeLEGKDILEVIAAGKEKFasvpsg-----ggggvvV 75  Physcomitrella ...
P90703         2 MKYLAAYLLSTMSGNkSPSAKDieDVLGSVGLDVDMEDANKVVsaLSGKSIDEVITAGLAKVssvps-------daavsA 74  agent of lympha...
ABK22480       1 MKVVAAYLLAVLGGNtSPSSDDikSILGSVGVDSDDDKIDYLLsqLEGKDITEVIASGREKFaavpsgggvavavsgggG 80  Sitka spruce
XP_571539      1 MKLIAAYLLLQQGGNaSPSAADikALLETVGVEAEEDRLSKLIseLEGKDINELIAEGSSKLasv-----------psgG 69  Cryptococcus ne...
AAW26781       1 MRYLAAFLLCQLGGKeKPTENDikTVLNSVGIEHDSERLTKLLasLSGKDIPQLIAEGSQKLssvpt--------agaaV 72  Schistosoma jap...
Q9LH85         1 MKVIAAFLLAKLGGNeNPTSNDlkKILESVGAEIDETKIDLLFslIKDHDVTELIAAGREKMsalssgg---pavamvaG 77  thale cress
EAZ06218     127 MRFVSAYLMAYIGGNeSPSKDDvrAILGSVGADVDEAKLDLLFeeIAGKDVPELIAAGRERLalaapc-----ggiaaaA 201 Indian rice
Q9LXM8         1 MKVAAAFLLAVLGGNaNPSADNikDIIGAVGADVDGESIELLLkeVSGKDIAELIASGREKLasvpsg------ggvavS 74  thale cress
ABA81865       1 MKVIAAYLLAVLGGNtCPSEKDlkKILASVGAEADDDRIQLLLsqVDGKDITELIAAGREKL-----------------A 63  potato
P17478        72 ATPAAGGAAgaeat----------saaeEAKEEEAAEe-sDEDMGf-GLFD 110 Schizosaccharomyces pombe
XP_001756207  76 ASASAGSGGaapaa----------evkeEPKKEEEKEe-sDDDMGf-SLFD 114 Physcomitrella patens subsp. patens
P90703        75 IAPVVSATPtdalqa--------gskkgETKEGPKEEs--DEDMGf-GLFD 114 agent of lymphatic filariasis
ABK22480      81 GAPAAAAAEpea--------------kkEEKVEEKEEs--DEDMGf-SLFD 114 Sitka spruce
XP_571539     70 AAPAAAAGGaaagga-------aeaapaEEKKEEAKEe-sDDDMGf-GLFD 111 Cryptococcus neoformans var. neoformans JEC21
AAW26781      73 SAPSSAPTApakaev-------pkaeskPAKTEVKEEsesEEDMGf-GLFD 115 Schistosoma japonicum
Q9LH85        78 GGGGGAASAaepv------------aesKKKVEEVKDe-sSDDAGmmGLFD 115 thale cress
EAZ06218     202 AGGQVVAAGgaaaa----------aaeeEEAEEEKKEeeeDDDDGlfNLFD 242 Indian rice
Q9LXM8        75 AAPSSGGGGaaap-----------aekkEAKKEEKEEs--DDDMGf-SLFE 111 thale cress
ABA81865      64 SVPAGGGAAccscctwwcavllhlllrrRRKKRKWKKk-rCQMMTwaSVFS 113 potato
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