Conserved Protein Domain Family
Ribosomal_P1

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cd05831: Ribosomal_P1 
Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins P2, P0, L11, and 28S rRNA. P1 and P2 are the only proteins in the ribosome to occur as multimers, always appearing as sets of heterodimers. Recent data indicate that eukaryotes have four copies (two heterodimers), while most archaeal species contain six copies of L12p (three homodimers) and bacteria may have four or six copies (two or three homodimers), depending on the species. Experiments using S. cerevisiae P1 and P2 indicate that P1 proteins are positioned more internally with limited reactivity in the C-terminal domains, while P2 proteins seem to be more externally located and are more likely to interact with other cellular components. In lower eukaryotes, P1 and P2 are further subdivided into P1A, P1B, P2A, and P2B, which form P1A/P2B and P1B/P2A heterodimers. Some plant species have a third P-protein, called P3, which is not homologous to P1 and P2. In humans, P1 and P2 are strongly autoimmunogenic. They play a significant role in the etiology and pathogenesis of systemic lupus erythema (SLE). In addition, the ribosome-inactivating protein trichosanthin (TCS) interacts with human P0, P1, and P2, with its primary binding site located in the C-terminal region of P2. TCS inactivates the ribosome by depurinating a specific adenine in the sarcin-ricin loop of 28S rRNA.
Statistics
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PSSM-Id: 100109
View PSSM: cd05831
Aligned: 51 rows
Threshold Bit Score: 55.4055
Threshold Setting Gi: 67473776
Created: 2-Aug-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAP68820       6 ELACIYSALILHDDEVTVTEDKi-nALIKAAGVNVEp-FWPGLFAkaLANVNIGSLIcnv---------gaGGPAPAAGA 74  human
AAW26900       5 ELACVYAALMLADDDIDVTADKi-nTILKAANIKFVesYLPNLFAtsLNGKNVKDLLmsmgsp--apsaavTSAVPTAAS 81  Schistosoma jap...
O46313         5 TLACTYAALMLSDAGLPTSAENi-aAAVKAAGVSVRp-TMPIIFArfLEKKSVEALMaaaatq--aptatsAAAAPAAGE 80  Leishmania peru...
133055         6 QLACTYAALILADSGKTDMDSLl--KVTKAAGVDVSk-GMASAFAsiLKNVDINDVLskvsfggvapaaggATAAPAAAA 82  Trypanosoma cruzi
XP_001437343  18 EAACTYAALILYEDNQEINAAKl-aQIIKAANLRVEp-IWTKVFEkaLKGKKVGDLLhg-----------nSGSAPAAQV 84  Paramecium tetr...
XP_636928      1 MSALDYATLILHDAKLAITADNl-vALCNAAGVKVEk-FKADLYAstLEKKKVDSILsv----------saAAAAPAAAA 68  Dictyostelium d...
XP_001706516   5 ETACVLAAIILADENQEPTAANl-kSICDAAGVKVDs-IWFTLFAnyLEGKNVKELLttl---------gsASAAPAPVT 73  Giardia lamblia...
XP_001885757   5 ELAPTYAALILADDGIGITAGRi-lALTTAAGVDMEp-IWADLLAkaLEGKEIKELLshidpg--gnldngTSAVIASNT 80  Laccaria bicolo...
XP_844856      4 QLACTYASLILSGSGNVDAAKLl--AVTNAAGVTVSk-GMAEAFAsiLGGISIDEVLgni---------afGGGAPVASS 71  Trypanosoma bru...
EAR90107       6 HQACTYAVLLLSDDGQAITVDNinkVLTKAKVQNVEk-YLPKLYVsnITPAVIASTIangg-------sssSGSAPAAAA 77  Tetrahymena the...
AAP68820      75 APaggpapstaaapaeekkvEAKKEESEEs-------DDDMGf-GLF 113 human
AAW26900      82 ATsaaaek------pkeavkEEKKVVSDDd------sDESIGf-GLF 115 Schistosoma japonicum
O46313        81 ASgk--------------aeEKKKEEPEEe------gDDDMGf-GLF 106 Leishmania peruviana
133055        83 AAaap------------aaaAAKKEEEEE--------DDDMGf-GLF 108 Trypanosoma cruzi
XP_001437343  85 ATtaapvaqq--tkapeaakEVKKAEEPEe-------DVDMG--GLF 120 Paramecium tetraurelia strain d4-2
XP_636928     69 APvaaa-----------aaaPAKKVVEEKke----esDDDMGm-GLF 99  Dictyostelium discoideum AX4
XP_001706516  74 AGgavaaa-------aaaaeTAKKEESDD--------DEIVGagGMF 105 Giardia lamblia ATCC 50803
XP_001885757  81 AAtt--------------dsEGHVDESGEsqdgddseDEIIFs-GLM 112 Laccaria bicolor S238N-H82
XP_844856     72 GGaaaaapaa---ggapaaaAPAKEEEED--------DDDMGf-GLF 106 Trypanosoma brucei TREU927
EAR90107      78 VAkea-------------pkEEKKAEEIKfn----alNQNINenIVF 107 Tetrahymena thermophila SB210
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