Conserved Protein Domain Family
LbH_M1P_guanylylT_C

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cd05824: LbH_M1P_guanylylT_C 
Mannose-1-phosphate guanylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Mannose-1-phosphate guanylyltransferase is also known as GDP-mannose pyrophosphorylase. It catalyzes the synthesis of GDP-mannose from GTP and mannose-1-phosphate, and is involved in the maintenance of cell wall integrity and glycosylation. Similar to ADP-glucose pyrophosphorylase, it contains an N-terminal catalytic domain that resembles a dinucleotide-binding Rossmann fold and a C-terminal LbH fold domain, presumably with 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.
Statistics
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PSSM-Id: 100062
View PSSM: cd05824
Aligned: 4 rows
Threshold Bit Score: 150.381
Threshold Setting Gi: 1709086
Created: 18-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P41940 256 LIDPTAKISstAKIGPdVVIGPnVTIGDgVRITRSVVLCNSTIKNHSLVKSTIVGWNSTVGQWCRLEgvTVLGDDVEVKD 335 baker's yeast
O74484 257 LIDPSATIGknCKIGPnVVIGPnVTIGDgVRLQRCAILKSSRVRDHAWVKSSIVGWNSTLGSWSRLEnvSVLGDDVVVND 336 Schizosaccharomyces p...
Q5KKH2 259 MVDPSAEIDptAVIGPnVVIGPdAKIGPgVRLQRCVIMSNATVRDHSWIANSIVGWNSTVGRWTRVEniTVLGDDVTIKD 338 Filobasidiella neofor...
Q7RVR8 259 LIDPSAKIGknCRIGPnVTIGPnVVVGDgVRLQRCVLLEGSKVKDHAWVKSTIVGWNSTVGKWARLEnvTVLGDDVTIGD 338 Neurospora crassa
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