Conserved Protein Domain Family
MPG1_transferase

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cd05805: MPG1_transferase 
GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an N-terminal NTP transferase domain, an L-beta-H domain, and a C-terminal PGM-like domain that belongs to the alpha-D-phosphohexomutase superfamily. This subfamily is limited to bacteria and archaea. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this group appear to lack conserved residues necessary for metal binding and catalytic activity. Other members of this superfamily include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100097
View PSSM: cd05805
Aligned: 24 rows
Threshold Bit Score: 475.968
Threshold Setting Gi: 83590759
Created: 11-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAB74060     384 LFGQRGVQGLANIDISPEFAVKLGAAYGSTLKPGAKVTVSRDQRNVSRMVTRSLIAGLMSVGVDIQNlDATAIPIARTVI 463 Nostoc sp. PCC ...
YP_480569    379 LFGPRGVSGLVNAEITPELVVRLAGAYATTLKKGATVTTARDGSRAARALKRAVISALTAGAINVRDlEVAPMPVTRFDV 458 Frankia sp. CcI3
YP_289455    384 LFGPRGVSGLINVEITPELAVRLASAYATTLKKGAVVTTARDASRAARTLKRAVISALTAAAINVQDlEATPLPLARFHT 463 Thermobifida fu...
YP_872989    393 LFGPRGISGLVNVEITPEHTVRLGAAYATTLRKGDVVTVSRDASRAGRALARAMISALTASAVNVRDlEAIPAPVARFEI 472 Acidothermus ce...
NP_954295    385 LFEGALIKGLTNMELTPEFVAKLGCAYGTTLPKGSFVISGRDAYRSSRMLKRSFIGGLLSSGVNVRDlTMVPMPVLRYKL 464 Geobacter sulfu...
YP_358363    387 LFEGASVRGLSNVELSPEFCAKLGAAYGSVLPRDSYVITSRDGQRSSRMLKRAFLGGLLSTGVNVRDiKQMPLPVMSYKL 466 Pelobacter carb...
ZP_01189116  383 LFTNTGVIGEGNIDITPEFVTRLAVAFASTIDRNKSITVSSDTYGLTSALKRAVISGIQLAGRNVLElGEITTAVARYGI 462 Halothermothrix...
NP_213493    385 IFKGNKVIGRINVELTPDNATKLGMALGSVLPPKSTVILARDYHRASRTIKRSFLGGILSTGINVIDlHLSPLPVMRFTL 464 Aquifex aeolicu...
YP_644210    388 IFRGGRVSGKFNVDVTPEFVIRLASSFGTTLSPGSIVTLGRDSSAAAQVVKRAMTAALLATGVNVRDlRAAHAGVVRHDV 467 Rubrobacter xyl...
YP_001358585 389 IFEDGRVTGKSNVEISCEMACQLAEAFAAHLPLGSTVIVGRDHSKSARMLKRAFLGGLLSGGVNIVDlKAMPPAVLRHNL 468 Sulfurovum sp. ...
BAB74060     464 PTMGVa-GGIHVRVHPDRaDYILIEFMDHKGINISKAQEKKIEGAYFKEDmrral-theiGDVAYPSQ----VIDLYCTA 537 Nostoc sp. PCC ...
YP_480569    459 RSSNAa-GGIMLRTTPGDpERIDIIFLDADGDDLSPVAQRKLDRVFSRQEfrraf-pgeiGDLRFPAR----TMDLYIQD 532 Frankia sp. CcI3
YP_289455    464 SQPGLs-GGIALRTTPGDpQSVDIVFLDSSGADLSPAAQRKLERVFSRQEyrraf-pgeiAELSFPSR----SVEAYTRE 537 Thermobifida fu...
YP_872989    473 AHSDAv-GGVIVRTTPGDaQSVDVTLLDENGADLSPAQQRRLERVFSRQEfrraf-pgeiADITVPYR----TLETYSQE 546 Acidothermus ce...
NP_954295    465 RSFGEv-GGIQFRQALDDpASTEIIFLDGDGLDFSSSMGKNVERIFFKENfrrahhtepgGLTEIPQQ----VMDFYREG 539 Geobacter sulfu...
YP_358363    467 GTFGEv-GGVHFHQFRDDpAATEIQFYDAEGFEISSGTAKSIERIFFKENfrrvh-yaepGEIRELPQ----LNAFYREG 540 Pelobacter carb...
ZP_01189116  463 INMQAg-GGIHIRLSYNNpEKVVLEFMNEKGVNLPAPDQKRVEKKFFTEDynrap-vndiGDYALVPE----MVNEYLYG 536 Halothermothrix...
NP_213493    465 TEDKKavCGVYFSISQEFpGSVEICVFDENGLPIDTNFQKKIERVFFREAyrfet-ftdlGLIKEKPY----FSENYVTK 539 Aquifex aeolicu...
YP_644210    468 LAGKSs-AGCHTRAGEDS-DEVEVLFFSSDATPMTEGEQRAIEKVFVREEyrrah-egdiGQLIFPGR----AVEQYVER 540 Rubrobacter xyl...
YP_001358585 469 GIKKElvAGIYFRQNVFDpTGVEFTFFSEEGLRIDGNMAKSVEKAFFQQDyrrvd-ydkiGRIEENYIhhlnECITYKKA 547 Sulfurovum sp. ...
BAB74060     538 FEKLLnvstlnnsraKVVIDYVYAVSg-AVLPQMLDkf--gaDAVVLNASLNk----nAVTTTd---rETLLTQLGHVVE 607 Nostoc sp. PCC ...
YP_480569    533 LLDRVdtagvaeadlKIVVDSSGGSAs-LVLPTLLGrl--gvDVLTVNGRVDet--ipPRSALe---dLRATDRLGALVA 604 Frankia sp. CcI3
YP_289455    538 LLQSIdlsgvaeanlKVVVDCAGGTGs-LILPALLSqi--daDVLTVNNRLDe----aSPTDTpa-krTRDLQRLGELVA 609 Thermobifida fu...
YP_872989    547 ALRCIdtsgiaeaglKVVLDTAGGTAa-LVLPTLLGri--gvDVLTVNNRLDe----lSPTETta-ehMRALERLGDLVS 618 Acidothermus ce...
NP_954295    540 FLHAIgktplqkkafKVVIDFNHSPAs-QLLPGILTqm--gcEVISLNAYVDeergvqALSDR-----GQSLSQLSKIVA 611 Geobacter sulfu...
YP_358363    541 FQRALdaqllrsfapKVVIDLNHSPAg-ELLPGLLSdl--gcEVVALNSHVEag--rsAVTPEq---tSRAMEQLARITG 612 Pelobacter carb...
ZP_01189116  537 ILDTVdteaikrnyfSVVIDYEYDSLn-HLLPLLLKrlncqmLSTRNYSRTGr-----PLSLQe---rLEARDKVSRILN 607 Halothermothrix...
NP_213493    540 LLSSIdgdsiklssnKVVYDALHSPIs-PFISEVLGkl--eiENVILNALYDer--klSRISTy---aSSSEGNVSKVLK 611 Aquifex aeolicu...
YP_644210    541 LERAVdrsr--vsggSVVVDFCGGVAg-LVASRVFSrlgisaVVMEGFANANvvg-gaPRMDL-----EEGLERVGRIVP 611 Rubrobacter xyl...
YP_001358585 548 VKEAIdhkiikkngfRVAIDLMYGGTkdIFPEIISElq---iENIILNSYTDy-----HKMANmahveKKSKDDISAIVK 619 Sulfurovum sp. ...
BAB74060     608 ALKANFGVQVSANGEQLILVDESGYPI-RGELLTALMVDMilts---nprGTVVVPVHASSAVEQVARRHDGRIIRTKAN 683 Nostoc sp. PCC ...
YP_480569    605 SSGAAFGVRFDHVGERVTIVDERGDLI-DDDRALLVFLDLvaae---npgAEVALPVTITRVADQVTRFHGLTVRRTSLS 680 Frankia sp. CcI3
YP_289455    610 SARADFGVRFDPVGERIQLVDGSGTLV-DDERALLVVLDLvaae---rqgGRVALPVTTTRVAEQVANRHGVDVQWTPTS 685 Thermobifida fu...
YP_872989    619 SSHAAFGVRFDAMGERLSLVDERGVII-HDDRALLVFMDLvaae---rrgGRIALPVTTTRVAEAVARFHGATIEWTPTA 694 Acidothermus ce...
NP_954295    612 TLEANAGFWLDPTVEGVIMVDETGTVHeGADILLLMVGLAlka----gekGVFAIPVSAPSAIERMAQERGCAVTRTKSA 687 Geobacter sulfu...
YP_358363    613 TLEATAGFWLDPSGEQLRIIDESGVLLsETEALGVVVSLVsrc----estGNLVLPVSAPMAMERIAQDGGLTTRAVKND 688 Pelobacter carb...
ZP_01189116  608 ENEADLGIIVDHNAERLNLVAGNKQVL-DPFKYQVMLSYLlle----rgvKKLFVPFNSPKVIENIADDYDADVVYTPLA 682 Halothermothrix...
NP_213493    612 ALSYDVGFVMEPSATKLKLVDDRGRTI-SGDRLLLVVLMLldks--aekqLRVYLPVWAPEVLDAILNNVIVERGKFTNL 688 Aquifex aeolicu...
YP_644210    612 TVEAAFGCVVNPTGEQVHFVDDAGEYVpPDVMLACLIRGLe--------pREVVLPINLSSRYAELVESYGGTVHYARTG 683 Rubrobacter xyl...
YP_001358585 620 NLKFNIGFLMYPNGQQLGIVGDDGEVLgRIKGLFVVLSLLnleakekekkLNVFLPTWAPDLTDELFENLVIERGKYANF 699 Sulfurovum sp. ...
BAB74060     684 ATALMEAcqknpnvVLGGSGETGFIFPqlhpGFDSMFCIAKIIEMLTIQERSLATVRSELPRVIYRTHTIRCPWSAKGAL 763 Nostoc sp. PCC ...
YP_480569    681 AAALTGVard-dgiVFAADGRGGFIVPefapAIDGIAAFVKLLALVARTRLTLSTIDARIPSVAILRRSVPTPWAVKGTV 759 Frankia sp. CcI3
YP_289455    686 LDALTKAala-ddiIFAADGRGGFILPefsrTCDGIAAFVRLIGLVARTKMSLSQIDQRIPQAHLLRRSVPTPWAVKGSV 764 Thermobifida fu...
YP_872989    695 PSELTRAarr-gdvIFAGDGRGGYIVPefsaALDGLAAFVRLTGLVARTKLTLSQIDGRIPQAHVLRRVVPTPWAAKGLV 773 Acidothermus ce...
NP_954295    688 DRSMIEAals-sevILAGSMDGRFAFPrfqaAFDGMFAIAKSIEMAARSGASISATAAEIPRRAFLHTRVPCVWDMKGGI 766 Geobacter sulfu...
YP_358363    689 ARALLEAvae-rggLLTATMDGRFALPvfqgHFDGMFAAAKILEMLGRTGMSLGAMRRTLPARAYRHTQVPCSRQLKGGL 767 Pelobacter carb...
ZP_01189116  683 PQVSMEK-------YMVYEHNPFKFYP----FNDAIAALVLILEKMAVENISFEQLLNRLPEFYLERVEIPCEWHDKGRV 751 Halothermothrix...
NP_213493    689 RKSFIEDf------YMLADTDGSFTFTefsySPDALYASLKIMEMLTKLKVKVSEIYDSLPEYYFLHEVVSCSSEKKGTV 762 Aquifex aeolicu...
YP_644210    684 MGNVAIRaae-raaDLGGLEDGQYIFPaflpAPDCFMTLARALELFRDRPLSKVRREFGERFGNVVRERLECPWSAKGRV 762 Rubrobacter xyl...
YP_001358585 700 KADKVKKy------DLVATIDGNFAFTefslHRDAMYASLKIMEMLSRHQVTISDISKQFERFYYNHIEVECSQAQKGKM 773 Sulfurovum sp. ...
BAB74060     764 MRYLVEthpaq---nlelIDGVKIRQpfddSWLLVLPDASEPLVHLYANSHERDWVDETVRDYRSRV 827 Nostoc sp. PCC 7120
YP_480569    760 MRRVVEsvdpdtgyvidtTDGVRIVGpd-gSWILVLPDPSEAVTHLWSEGADIEEAHVLLRRWVEVV 825 Frankia sp. CcI3
YP_289455    765 MREVVEaaqgr---eidtTDGVRVIEpd-gSWALVLPDTAEAVTHLWAEGPDDETAQRLLEEWSAVV 827 Thermobifida fusca YX
YP_872989    774 MRSVLHaaggk---pvetTDGVRIVEde-qSWVLVLPDPAEAITHLWAEAPDADAATELLEKWASVI 836 Acidothermus cellulolyticus 11B
NP_954295    767 MRKMSEdsldk---easfIDGIKVHFg--eDWALVLPDQYQPHVHIVAEARDPKAAQKLLTEYQKKV 828 Geobacter sulfurreducens PCA
YP_358363    768 MRKMSEhsvnl---dasfIDGVKVRFd--dDWVLVLPDQYRPVMHIVADSPDAQRAESLLVSYQGKV 829 Pelobacter carbinolicus DSM ...
ZP_01189116  752 MRRLAEeard----ntelVDGIKFNHr--nGWALVIPDNEEPVFHIFAEGQDEETAESLTGFYIEKV 812 Halothermothrix orenii H 168
NP_213493    763 LRKISEmaegk---easfIEGVKIYEdy-gNWVLVLPDSYKDLIHVYVQSTERERAEELIKNYMEIV 825 Aquifex aeolicus VF5
YP_644210    763 MRGLAErfggd--pdailTEGVKLMVd--gGWVLMLPDPDNPLFYVYAEADDGRRPEALMQDYVRLV 825 Rubrobacter xylanophilus DSM...
YP_001358585 774 MKRFFQeakdk---ksctTDGVKIWEne-tDWILMIPDQVRDLLHLYVQAKDKNSGEALAARYEANI 836 Sulfurovum sp. NBC37-1
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