Conserved Protein Domain Family
StaR_like

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cd05804: StaR_like 
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.
Statistics
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PSSM-Id: 100115
View PSSM: cd05804
Aligned: 40 rows
Threshold Bit Score: 245.271
Threshold Setting Gi: 111224760
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAM80544     517 LDPGFTAGHAALALIghecgadvdv---pralaearrCARERADERER-SFVEVVSRRVEGSPaeGDAALLRHLDSHPGD 592 Streptomyces to...
EDP63448      45 ADDGFALGYAALARTrqamgmggd----tktpmaaaqALAGGLSAREA-AHVDALGLLVAGNGpaAYKAIRTHLLEHPRD 119 alpha proteobac...
YP_001208425  45 LDPDFALAHAARARIhaiymqreaa---lqtikrardLVAKRGTEREK-SHVATLVLAIEGRGtdALHAALTHLESWPRD 120 Bradyrhizobium ...
EDQ05743      44 ADADFALPHVVLARYrqligdrtg----aklaletarQCKRVQTDRER-RQINIIGLLLAGQSaeGYRAAREQLKDYPRD 118 Oceanibulbus in...
NP_767934     46 ADPDFALPLIARARVhafyqqgdla---rqkaaaareLVAKRGTERER-SHVETLALAIEGRLpeAIEATLKHVEAWPRD 121 Bradyrhizobium ...
YP_001110397  46 ADPHFALAYAARARLhairaevsda---rskiaqateVVGRNGTERER-SHVQVLSFAINGQApkALAAALEHTDKWPRD 121 Burkholderia vi...
EDQ40276      46 ADPDFALAHAARARLhamcaepaqa---rariaaaaeRVARRGIERER-SHVEVLSLAINGQParALERALGHADAWPRD 121 Methylobacteriu...
YP_001251928  45 TDNLLIQTYAAAFYLyaqedvaneq---asdylqsasRLLTSANEREK-LTFEAVTNWSKRDYanAISLLVTLLERYPRD 120 Legionella pneu...
NP_903814     53 VGFDAITSCELKDLYkftl--------------clqqLAPEEADCPELrLLVAAFRAWVSFDYprARLLFRQHLDIYPSD 118 Chromobacterium...
ZP_01079424    8 AERGDVIPLQLLTALveltvqapdaqtravarlqqcqIQRQRLDAWGQ-QLLEAGLLWGAGALgsALRRLVDLAERAPEG 86  Synechococcus s...
AAM80544     593 RLala---aaVPTIAFSGLYDLDgsaalrvv---ertapahEGHWFHTSLLAFVRQEQGRYdEAGTLAEQALGEEPASGH 666 Streptomyces to...
EDP63448     120 AMiaqtctgvFGMIGFSGKPGREaeqlaft----aalaphyGEDWWFLCQHAFSQVEAGQTgPATETIERSLALHPRNAH 195 alpha proteobac...
YP_001208425 121 AMimalplgaFGLLAFSGRRDHDaarrdlc----nrfaaayGEDWWFLSNHGWALTEAGEVsQGRAITERSFALRRHNAY 196 Bradyrhizobium ...
EDQ05743     119 VLiaqaclgvLSLIGFSGQPGREaenlala----eilephyGDDWWLQGLLGFAQVEVGQFdRAEQSIAKSLAANPRNAH 194 Oceanibulbus in...
NP_767934    122 AVvlslplgaFGLFAFSGMADHDrarhelc----ervarhyGEDWWFLTMSGWAMTENGDVaRGRGITERGFALRRQNAH 197 Bradyrhizobium ...
YP_001110397 122 ILilslplgaFGLFAFSGMANHDqarvdlce---rharhfdADDWWFLTYRGWAHGENGNVqLGRAMTQRSLELRRHNVN 198 Burkholderia vi...
EDQ40276     122 ALilslplgaFGLLAFSGMTDHDqarvdlce---rharhydADDWWFLTYRGWSHAENGAVkHGRALAERGFALRRANAN 198 Methylobacteriu...
YP_001251928 121 TLalk---fvEWLFYCTGQAFNAeyflkvc----dkcapenQDESHFLAIHSFALELCGQYsKAREMAEEAITMNLHTPW 193 Legionella pneu...
NP_903814    119 IVa------lFFTHMFDFCTGHTpelmpdlercdrhigedhPLYSYYLSIKAFVTVEAGHPaQALKLGLESLRHRADNIY 192 Chromobacterium...
ZP_01079424   87 LLvlk---iaEWLTYLRGQELHGpalldls----lifeashGSDPDWLAIHAFALELCGCCpEAIAAAQAAIGARSLNPW 159 Synechococcus s...
AAM80544     667 AMHALAHVHYEQGDhPQGRDRLDAWLGGHg-rGGTHRAHFAWHAALHELASDDaEAVRRRWATHLspgk--vagiRALVD 743 Streptomyces to...
EDP63448     196 AAHIRSHVYYEAGEtEAGYRYIDDWRRDYd-kAGQLHCHISWHVALWALERGDvETMWRVLDADVapdaawgpplNLVTD 274 alpha proteobac...
YP_001208425 197 AVHALLHAMFEQGSlAEAGALVEGWIGDYd-rTGMLHGHICWHQALGALDRGDaAGALRVYTDVLlptmdtapplNTLSD 275 Bradyrhizobium ...
EDQ05743     195 GAHFQSHLYYETGQtDAGYVFITDWQSAYe-kEGQMHCHIAWHIALWALARGDiDEMWRIVDSDIdprgawgpplNVMVD 273 Oceanibulbus in...
NP_767934    198 AAHAVLHAMFEDGSiEAADRLVDEWIPTYd-rAGILHGHIRWHQALGALEHGDaARALAIYADVLqpsatqapplNVVTD 276 Bradyrhizobium ...
YP_001110397 199 AVHAVAHVLYECGAnDEAEGVIAGWLPEYd-kSGVLHGHIAWHAALIALERGDtDRAIAVYNEHVapsastgvpvNVVSD 277 Burkholderia vi...
EDQ40276     199 GAHALSHAMFEGGAgEEAEALIAEWLPGYd-rSGILHGHIAWHAALSALERDEpQRALAIYAEHVqpsvtaglpiNVVSD 277 Methylobacteriu...
YP_001251928 194 AHHTLAHVHLLTSDiTGGINRLRDLQKTWediLPLLKGHNTWHLALFYLANRDeEEVKKLYPHISgalp---dtvLEQLD 270 Legionella pneu...
NP_903814    193 GIHAVAHALHEQECwKELCLFLEQCKAQWi-dNAGMRMHVYWHLAIGYEKSQQtEQSVRTFHDMYalkd--srfaKQDLD 269 Chromobacterium...
ZP_01079424  160 ADHALLHAWHRQGDlDRALDWAGQRRASWseaLPAMRLHNRWHAALLSLEMGQpDRAIPALAEFRget-----gtGPLLD 234 Synechococcus s...
AAM80544     744 SGSLLWRARMAGhwqgrVPVDDVLESVAAdv---leRPATA-------FTALHAAVTLTAagdlPGLRRLQAHALgad-- 811 Streptomyces to...
EDP63448     275 TASLLYRAELAGv----AVPAERWKQVSDt-----aARIFPnpg--iaFADVHAALAHAMagngTALSKIIADAKg---- 339 alpha proteobac...
YP_001208425 276 CASLLWRLRAENh----TLPDGAWTEVAAy-----aRPRFTgst--laFIEMHLVMIAAAtndtTALKGRLAAIErrqie 344 Bradyrhizobium ...
EDQ05743     274 LAAVLYRAELAGi----AVPQARWQVVCDy-----aAEHFPnpg--lgFADVHASLAYAMagrsEALERIITGAKg---- 338 Oceanibulbus in...
NP_767934    277 GASLLWRLSAYGh----AVPQELWLDADAa-----aQKLFPkss--lpFADVHMALFAAAtqnrDALAARLAVIEqrvae 345 Bradyrhizobium ...
YP_001110397 278 SASFLWRMQAYGh----SVPAGMWDEAARy-----aSGYFKqag--faFADFHMTLVAAAtgdkAALGQRVDDLVklvea 346 Burkholderia vi...
EDQ40276     278 TVSLLWRMQAYGy----KVPAGLWDDAKVy-----sSKYFTkag--faFADAHMGLLAAAtgdkAAAVARIDALTdlvaa 346 Methylobacteriu...
YP_001251928 271 TISLLWRMDMAG-----LPQDRLLNQVVDh------LSTHPlef-ytgFTNAHFIYCLVKsgykNEADESLKRMKsyaca 338 Legionella pneu...
NP_903814    270 AVAFLWRYRLNHpg--dNRFDDVWQQLAF-------LWSGSigasmshFHRLHAALAFAAsgqpVLIEKLIAESDgfgl- 339 Chromobacterium...
ZP_01079424  235 AIALGWWLDLSA-----APQETLWSSLVPlvqerlcLPLIP-------FIACHYAWCLGRagqqQDLETLLDHCRdqarv 302 Synechococcus s...
AAM80544     812 ------svQRAVIAPLCEAFaHVVEENWAeAAQRLERVLPalraVGGSAAQREVVEETLV 865 Streptomyces toyocaensis
EDP63448     340 -------pAGDLVRTLAEGFrAIADGEWEaATGHLTRSMAdherIGGSRAQRDLVEYALL 392 alpha proteobacterium BAL199
YP_001208425 345 ----gnlpAGRIVPHMLRALrAFAEENWRaCARELTPVMGdlarIGGSHAQREVIEDTYV 400 Bradyrhizobium sp. ORS278
EDQ05743     339 -------pVAQLVSSLAEAFgAIADQNWTrANDLLTLALWdharLGGSRAQRDLIEYASV 391 Oceanibulbus indolifex HEL-45
NP_767934    346 ----gklpAGPVVPAICRALaAFADEDYAaCVRTLAPALAdvvrIGGSHAQRELIEDTFI 401 Bradyrhizobium japonicum USDA 110
YP_001110397 347 ----gqlpAGSVVPAICRAAlAFAEENYTlCAEILEPVARdvvrIGGSGAQREIVEDTLL 402 Burkholderia vietnamiensis G4
EDQ40276     347 ----gtlaAGPVVPAICRAVlAFAEEDYAgCVRILEPVAAevtrIGGSGAQREIIEDTLL 402 Methylobacterium nodulans ORS 2060
YP_001251928 339 p--ssdalWGDVVLPLCQGIyAFADADYKtALMLMEPVIGecaqLGGSDAQIELFFQTYL 396 Legionella pneumophila str. Corby
NP_903814    340 -----dpqTHQTGVTVLKGIhHFAEGRYAdSLGALQAAQPhwsvLGGSRAQRELLPLTLQ 394 Chromobacterium violaceum ATCC 12472
ZP_01079424  303 agpeagwcWRPAGLTLVEAIgAAACGRRAtAWELLAPIRGwidhAGGSDAQARVLHQTVR 362 Synechococcus sp. RS9917
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