1TUO


Conserved Protein Domain Family
PGM_like2

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cd05800: PGM_like2 
Click on image for an interactive view with Cn3D
This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four structural domains (subdomains) with a centrally located active site formed by four loops, one from each subdomain. All four subdomains are included in this alignment model.
Statistics
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PSSM-Id: 100093
View PSSM: cd05800
Aligned: 38 rows
Threshold Bit Score: 551.773
Threshold Setting Gi: 162447916
Created: 4-Nov-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) and Pseudomonas aeruginosa PMM/PGM bound to their substrates and divalent metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           # #  #                                                                       
1TUO_A        12 IRFGTEGFRGVIAreFTFATLHRLAEAYGRHller--gggLVVVGHDTRFLADAFARALSGHLAGMGLKVVLLKGPVPTP 89  Thermus thermop...
AAR35389       4 ITFGTSGWRGILCedFTFENVKVVSQAIADHvkaigeqdkGIIVAYDTRFMGERFAKETVRVLAGAGVKAYFCRRDTPTP 83  Geobacter sulfu...
YP_056950      5 IEFGTGGWRAIIAdtFTRLNVERVAQALADRihdenqehrPVVIGYDQRFLSPEFAWWAAEVLAGNDIVVRIIDRPAPTP 84  Propionibacteri...
9655043        2 IKFGTGGWRAFIGeeFTKDNVRLVAQALANIihheqaaneGFVIGYDRRFLSDKAGRWFAEVLAANGVVVSFIDKFVPTP 81  Vibrio cholerae...
YP_590826      5 IKFGTSGWRAIVAedFTFANVRRAVTGIAKFvarr-dqhpSLIVGRDPRFLGEAFVAEAAAILASHGVKPFVINDAAPTP 83  Acidobacteria b...
YP_001180164   4 ITFGTDGWRGVIAddFTFDNVKIVAQAISDYvlet-yenpKIIIGYDYRFHSENFAKICADILSANAIHVLFSNNPIPTP 82  Caldicellulosir...
YP_001114427   5 ISFGTDGWRGIIAkdFTFDNVRLVARAVAAYineeaigerGIVIGRDNRFLAEEFAEAVAEEFNKQGIPVYMCCGATPTP 84  Desulfotomaculu...
YP_429099      3 IKFGTDGWRAVIAdeFTFANVRLVTQATANYllre-agsgKIIIGYDNRFLAPEFARAVAEVLTASGFTVYLPSRAVPTP 81  Moorella thermo...
ZP_02084325   24 VKFGTGGWRAIIGeeFTKENIQKLALAICLKmkaegvegqGVVMGYDRRFLSKEAIIWSCEIFGNQGIRVWFVNRSSPTP 103 Clostridium bol...
YP_001469830   3 IKFGTSGWRAIMGdqFTFSNVKIVTQAIAEYlkkn--ggrKVIVARDTRFMTENYAQLVAEVLAANGIKVLMPENPTPTP 80  Thermotoga lett...
Feature 1                           ###       #                                                  
1TUO_A        90 LLSFAVRHLKAaGGAMLTASHNPPQYLGVKFKDATGGPIAQEEAKAIEALVPEear-----------------------a 146 Thermus thermop...
AAR35389      84 VISFEILRRGTaGAVNFTASHNPPEYNGIKFSPSWGGPALPETTGDIERRANEmmgevcyre-----------maldeav 152 Geobacter sulfu...
YP_056950     85 MIMWTVRDLGCaYGMAVTASHNPATYNGLKVFTEGGRDAKVEITEPIQHRANSispkdirrv------------hrtdal 152 Propionibacteri...
9655043       82 VVMFKAKAMDCaYSACITASHNPADYNGIKVFIRGGRDADEVITQKIEQQIATltlqdvksi------------dfdqav 149 Vibrio cholerae...
YP_590826     84 GIAWEIMTRKTgGAINFTASHNPPEYNGIKYSTPDGAPALPETTQGIEAEIAKldavdpv----------------kpns 147 Acidobacteria b...
YP_001180164  83 AVAHAVVKKEAsGAIMITASHNPYYYNGIKFIPHYGGPANTQITDKIIKNVERiqkeglk----------------dinp 146 Caldicellulosir...
YP_001114427  85 VTAYAIKLHQAaGAVMLTASHNPPPYNGFKFIPETAGPALPHITKKIEENIAKlqagepcegyslipaegrygalvaeek 164 Desulfotomaculu...
YP_429099     82 VTAWAIKHYQAmGALMLTASHNPPEYCGLKFIPEYAGPAVPAITSAIEKEIAAvinggevkt-----------lnldear 150 Moorella thermo...
ZP_02084325  104 LVMFYVMKHELsYGMMVTASHNPAIYNGIKVFTYGGRDADEKQTAEIEYYLEQaeelylpneeeng---qmpppsylelv 180 Clostridium bol...
YP_001469830  81 VVSYAIRHYKLdGGINITASHNPPEYCGIKFNPSDGSPAPTEVTSEIEKLIEKiderkiplm------------nlreas 148 Thermotoga lett...
Feature 1                                                                                        
1TUO_A       147 leGAYETLDLREAYFEALKAHLDlkalsgfsgVLYHDSMGGAGAGFLKGFLRhvgleipvRPIREEPHPLFHGVNPEPIP 226 Thermus thermop...
AAR35389     153 kaGLLEEIDPREEYLKALESKVDfdai-grvgSVAVNALYGTGRGYLEEPLItrg--ldvKAINMHRDPYFGGFPPEPSE 229 Geobacter sulfu...
YP_056950    153 rdGVIEVQTSMNWYIDAILDHVDleairhahlKVVLDPMFGVSRTCLQTILMtar--cdvDTIHERRDTLFGGRLPSPNS 230 Propionibacteri...
9655043      150 ndKLIDIINPMNEFVDSIINFIDieaikkanlRVLIDPMFGVAKNALQTVLIngr--cdvDVINDGKNPDFGGLMPSPSA 227 Vibrio cholerae...
YP_590826    148 sdPEAETIDIKANYLSRLKEVVDlaaikksglKVVYDPLWGAARGYPDSLLRdag--vstATVHDVRDVLFGGHAPEPDD 225 Acidobacteria b...
YP_001180164 147 dkDLIEYFDYKEVYLNDILNLIDkkafkgkqlKVLVNPMYGCGIGYIDEALRrlg--cdvKVINNWRDPLFGGHLPEPNL 224 Caldicellulosir...
YP_001114427 165 ptTGCTMHSPFEEYIEHIATIIDldtirqaglKIVIDPMFGAGIGYLEHILGnag--aelEVFHNHRDPLFGGTLPEPTG 242 Desulfotomaculu...
YP_429099    151 grGLVRELEPEADYREYLHGLIDvealrkaglKVVVDPLYGAGIGYLEDFLRgag--cqvQAIHNYRDPLFGGDLPDPSA 228 Moorella thermo...
ZP_02084325  181 rkGMVREINPMNEYLDNIISVINmdaikerdlRIAIDPMYGVSLTALSTILSiar--ctiETINSRHDTLFGGKMPAPTE 258 Clostridium bol...
YP_001469830 149 skDLFEIIDPKPDYFKALSELIDieriksaglRVIADLLYGSSIGYLDDLCQtic--sdlDVVHNYRNPYFGGGRPEPDE 226 Thermotoga lett...
Feature 1                              # # ##                                      #             
1TUO_A       227 KNLGVTLAVLgpetppSFAVATDGDADRVGVVLpggVFFNPHQVLTTLALYrfrk-ghrGRAVKNFAVTWLLDRLGERLG 305 Thermus thermop...
AAR35389     230 KYIQDFIRLVkddpaiRLGIATDGDADRFGIVDgdgTFIEPNYIIALLFDYlvrvrkmtGAVARSVATSHLVDAVAKKHG 309 Geobacter sulfu...
YP_056950    231 RTLQTLAQEVver-gaDIGIATDGDADRLGIIDdqgHFLHPNQILVLLYTYlledkgwqGPCVRNLATTHLLDRVAEAHG 309 Propionibacteri...
9655043      228 ATLYRLKHLVkhe-gyDIGIGTDGDADRLGIIDekgNFIHPNEVLILLYYYlleykgwkGSVVRNIATTHLLDKIAADHG 306 Vibrio cholerae...
YP_590826    226 HLLNDLRAKMket-gaGIGIATDGDADRFGIVDadgTFIQPNYIIALLFDYlvetrgwkNGVAKSVATTNLVNALAEHHK 304 Acidobacteria b...
YP_001180164 225 ENMKDLLEIIkte-efDLGLATDGDADRFGVVNpdgQFISANEVIFLLTDYlintrgkaSSVARTVATTSMIDKIAQKHG 303 Caldicellulosir...
YP_001114427 243 KSLEELKQRVtag-kaHLGLALDGDADRFGIIDangEYITPNQFLPLLYYHlltvkgwrGPVARTVATTHLLDRMAAKYN 321 Desulfotomaculu...
YP_429099    229 RGLEELSRRVret-gaHLGLALDGDADRFGVVDgdgTYLTANQVLYLVLAHlimdrhyrGPVARTVATTHNLDRLARAHD 307 Moorella thermo...
ZP_02084325  259 RTLRNLQNYVldr-ycDIGIATDGDADRLGVIDdqgHYLHANNILVMLYYYllkykgwrGPAVRNLATTHVLDKVAESFG 337 Clostridium bol...
YP_001469830 227 TRLSEFSSRIknl-nwDVLISTDGDADRFGILDnngEFVKPNEIIALLAYHlyknkgkiGPVARTIATSHAVDAVAHTFK 305 Thermotoga lett...
Feature 1               ###                # # #                                                 
1TUO_A       306 FGVTTTPVGFKWIKEEflkgdCFIGGEESGGVGYPEHLPERDGILTSLLLLESVAatgkDLAEQFKEVEALTglTHAYDR 385 Thermus thermop...
AAR35389     310 IEVIETPVGFKYIGELisqdrIIIGGEESAGLSIKGHVPEKDGILACFLVAEMVAreglSVKALLARLYEEVg-TFVTKR 388 Geobacter sulfu...
YP_056950    310 QTCYEVPVGFKWVSSKmaetnAVIGGESSGGLTVQGHIAGKDGVYAGTLLVEMIAkrgkKLSQIYADIEERYg-RLEMVE 388 Propionibacteri...
9655043      307 ERCFEVPVGFKHISSQmeaddSLIGGESSGGLTIRGHIKGKDGVFASSLLVEMISvtgkKLSELLTEIYDRYg-YAYTAE 385 Vibrio cholerae...
YP_590826    305 VELHETPVGFKYIGELikqdkIAIGGEESAGLSIRHHVPEKDGVLACLLCCEMVAkrgkPMGAQLHELFGKVg-SFYPER 383 Acidobacteria b...
YP_001180164 304 MRCIETPVGFKYIAEClmkedALIGGEESGGLSIKGHVPEKDGILADLLVAEAVAklekSPKEILDRIESEYg-KLYNKR 382 Caldicellulosir...
YP_001114427 322 QPIYESPVGFKYIGQNllekdCILGGEESGGLSIKGHIPEKDGILAGLLAAEMVAqhgkSLTAILESIYQEFg-RLFSER 400 Desulfotomaculu...
YP_429099    308 LEIIETPVGFKYIGEAlrekgCILGGEESGGLSIRGHIPEKDGILATALVAELRAvrgrSLGEILADLHSSYg-HLVNQR 386 Moorella thermo...
ZP_02084325  338 QKCYEVPVGFKHISAKmqetdAIIGGESSGGLTVKGHIHGKDGIYAAALLVEMIAvsgkRLSEIAADIRKEYg-AIHMAE 416 Clostridium bol...
YP_001469830 306 QKVLETPVGFKFLATVlmsenAVIAGEESGGLSIANHVPEKDGILACLLVLEMIAyekkSLSEIRKQFEKEYg-KFNNTR 384 Thermotoga lett...
Feature 1                                                             # ###    #                 
1TUO_A       386 LDLP-LKAPLDLTPFREPRPlagltp-----kgvdtlDGVKWLYe--eAWVLFRASGTEPVVRIYVEAQSPELVRALLEE 457 Thermus thermop...
AAR35389     389 ENIT-LSPAVEEGYAEKQRQapdsfagl-kvtqkvtvDGSKFILed-dSWLLFRKSGTEPVVRLYAEASSEEKLAAVMAA 465 Geobacter sulfu...
YP_056950    389 DDFS-FAPEDKEYLKRRIYQdkdlpdfglevdhisdmDGVKVYFan-gGWIIVRFSGTEPLLRVFCEMPVAQMARECIDK 466 Propionibacteri...
9655043      386 GDCK-FKPAQRDEIYNKVYIekklpefefdidkvsyeDGAKVYFkn-gGWVIARFSGTEPLLRIFAEMADKDTAERVLQQ 463 Vibrio cholerae...
YP_590826    384 QNFH-LTPEQKETFTKKLKSepkdfhgk-rvveinrkDGLKLVLdd-gSWVCYRVSGTEPVVRAYTEARSEQGLKDLSAA 460 Acidobacteria b...
YP_001180164 383 IDVR-TTHSKKQEALERVKNfgkdsiaglkcleyrtrDGLKVILed-eSWFLVRASGTEDLIRIYAESKDAKTLENILSE 460 Caldicellulosir...
YP_001114427 401 LDIH-TTPQQKTAILEQLKDfsptelggqpvidkitlDGVKLIVad-gAWVLIRASGTEPLFRIYTEANSLEQKVRLQQD 478 Desulfotomaculu...
YP_429099    387 LDIK-VDPATKERVLQELPDfapakvagipvtgrltvDGVKLTLad-gSWVLLRPSGTEPLLRLYAEAPDAGRLRLLQKE 464 Moorella thermo...
ZP_02084325  417 RDYR-FTPEEKERIHNILMEerklpempfetdhvsymDGCKVYFkn-gGWVIARFSGTEPLLRIFCEMEYEPDTVRVCNL 494 Clostridium bol...
YP_001469830 385 IDIDfQSDEEKKQFLDKFKNiedylvnl-kivdedsvDGMRYFFdkdgSWLLVRPSGTEPIVRIYLESRDLQTLQTMLSA 463 Thermotoga lett...
Feature 1             
1TUO_A       458 ARKLV 462 Thermus thermophilus
AAR35389     466 GKQFI 470 Geobacter sulfurreducens PCA
YP_056950    467 VVKHY 471 Propionibacterium acnes KPA171202
9655043      464 MKAFL 468 Vibrio cholerae O1 biovar eltor str. N16961
YP_590826    461 AKQFV 465 Acidobacteria bacterium Ellin345
YP_001180164 461 VKEYL 465 Caldicellulosiruptor saccharolyticus DSM 8903
YP_001114427 479 VKNKL 483 Desulfotomaculum reducens MI-1
YP_429099    465 ITTAL 469 Moorella thermoacetica ATCC 39073
ZP_02084325  495 FEEYL 499 Clostridium bolteae ATCC BAA-613
YP_001469830 464 VRKIS 468 Thermotoga lettingae TMO

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