Conserved Protein Domain Family
PGM2

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cd05799: PGM2 
This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100092
View PSSM: cd05799
Aligned: 118 rows
Threshold Bit Score: 419.219
Threshold Setting Gi: 19172995
Created: 1-Nov-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) and Pseudomonas aeruginosa PMM/PGM bound to their substrates and divalent metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            # #  #                                                                      
AAH10087      54 RMEFGTAGLRAAMGPGisRMNDLTIIQTTQGFCRYLekqfsdlkqkGIVISFDARAHpssggsSRRFARLAATTFISQGI 133 human
14248265      72 KLTFGTAGIRGKFGLGegRLNKFTIEKLALGLARYLnaqt---nspTIVIHYDIRHL------STEFAQIIANVLANHQI 142 Staphylococcus ...
YP_301827     33 VLSFGTAGIRSTFGLGpaRLNAFTVRKVALGLAQYLnhnv---ddaSVVIHFDTRFL------SKAFSQEMASVLANNGI 103 Staphylococcus ...
NP_757495     53 KLSFGTAGIRATMGPGtnQINVFTYQQMSEGVARWLlnkk---snpTVIVAHDNRMN------ADYYAMVIAKTLTSFGI 123 Mycoplasma pene...
NP_853364     54 PLGFGTAGIRQKMGPGyrYLNDFTYAQMAFGYGRFLidkf--gfspRCVIAHDNRKN------GVHFAKIITDVLTSMGI 125 Mycoplasma gall...
1352196       39 PLSFGTAGIRAKMAPGtqFLNKITYYQMATGYGKFLknkfs-nqniSVIVAHDNRNN------GIDFSIDVTNILTSLEL 111 Mycoplasma pirum
NP_072713     41 KPLFGTAGVRNKMAPGyhGMNVFSYAYLTQGYVKYIesinepkrqlRFLVARDTRKN------GGLFLETVCDVITSMGH 114 Mycoplasma geni...
6899534       42 RFKFGTSGVRCIYEEGtrYLNAITYTQLTLGFIEYLetkk--nfnkIIVIGRDNRFG------SRENLKLVAEIFSSFDY 113 Ureaplasma parv...
YP_001256604   3 KLEFGTAGIRGKIGSGveNLNIAHVRRIMHGYAKYLlnkya-kqeiKIVIGRDNRRK------SYSFALCSAQILDSYGI 75  Mycoplasma agal...
YP_015960      3 ELEFGTAGLRGILGKTkeHLNIFHVARVIEGFAKYLksetfnwknkIVIIGRDNRRK------SREFSRLAASILAFHKI 76  Mycoplasma mobi...
Feature 1                                         ###       #                                    
AAH10087     134 PVYLFSd--ITPTPFVPFTVSHLklCAGIMITASHNPKQDNGYKVYWdnGAQIISPHDKGISQAIEEnlepwpqaw--dd 209 human
14248265     143 TVYLPDt--YKTTPELSFAVRNLntTAGIMITASHNPKDYNGIKVYGsdGAQLSTDASELASRYIEEvgdplqid---ip 217 Staphylococcus ...
YP_301827    104 TAIISDn--YKSTPELSFAVRHLqvNAGIMITASHNPKNYNGIKIYNekGGQLLPEASEQLSEYINSietplniek-gdf 180 Staphylococcus ...
NP_757495    124 KVFLYKenqIKATPIISYSVRETgvDAAIIATASHNPKNYLGFKVYNhtGGQILDSEANEIVSSMPEcqtiidn------ 197 Mycoplasma pene...
NP_853364    126 EVYLFDnnkISSTPILSYAIPRYnaDGGINVTASHNRKTDNGFKTYNekGAQLLNQDAQKIIDFMPKsceilnl------ 199 Mycoplasma gall...
1352196      112 EFICLKiinLLLRQLFSYAIRKLnaQGAVIVTASHNPKEDNGFKIYNetGAQVLPDDGLKVVELMPNvfemidl------ 185 Mycoplasma pirum
NP_072713    115 LAYVFDdnqPVSTPLVSHVIFKYgfSGGINITASHNPKDDNGFKVYDhtGAQLLDTQTNQLLSDLPCvtsmldl------ 188 Mycoplasma geni...
6899534      114 TVYINEdygMLSTPITSFLINQLqaGAGIMITASHNPKNYNGFKVYNanGAQPLVDDTNLIESLMPSytealdf------ 187 Ureaplasma parv...
YP_001256604  76 KVYFSKn--ICPTPFVSYSIMHYkaHGGINITASHNPKEYNGIKLYNesAFQMLPEEIQEVSSYFDDyekylepyktvks 153 Mycoplasma agal...
YP_015960     77 NVLISRe--IIATPIISYATKYHkaLGAINITASHNPKEYNGIKLYDknGSQILPDVVDKIKSNFLNyedytkkqalnqf 154 Mycoplasma mobi...
Feature 1                                                                                        
AAH10087     210 slidssPLLHNPSAS-INNDYFEDLKKYCfhrsvn---retkvKFVHTSVHGVGHSFVQSAFKAfdlv-------ppeaV 278 human
14248265     218 iskqntSYIKPFPKS-VTDDYMKHIQNMIgyip------ksdlQVVFTSLHGTSVPIVPELLKSlnfn-------qfnlV 283 Staphylococcus ...
YP_301827    181 nafvenGKIKYMSNE-VTESYKKEVKSLVgsid------ahdaKVILTSLHGTSLPLVSDILTEldyh-------nfviE 246 Staphylococcus ...
NP_757495    198 vytpnmDLISYFDDT-ITESYFEASYRCLintniy---rqknfPVILTTHHGTASYDLPYLLKSigye-------niilA 266 Mycoplasma pene...
NP_853364    200 eyqpndRLVKFIPDE-IYDRYFADIYRDLyttdhk---evkdfKVIFTGQHGAASYWLPEMLRRfnyn--------vipV 267 Mycoplasma gall...
1352196      186 kvanddSLITYLNED-IFRQYYEDCKQALiktnin---eskefSIVFSGQHGTACKRLPEFLKLlgyk-------niilV 254 Mycoplasma pirum
NP_072713    189 elqpnpKFVHTLDNEkVYKNYFRELKKVLvinnn----nfkdiKVVFSGLNGTSVCLMQRFLKYlgys-------niisV 257 Mycoplasma geni...
6899534      188 nfefkqDNIRFLTKE-QIQSYFDAVKAQLintdpn---ikkpfKIVFSGHHGTTTKDMIPFLESlgyd--------mvsV 255 Ureaplasma parv...
YP_001256604 154 ikksefNNLEFISEK-VKDKYLNSVAQIAnnldksvnlnpeniKVVYSPLHGTGSKFVPKLFKKlfsesaydinesifyV 232 Mycoplasma agal...
YP_015960    155 ifsiknKYINYIPKQ-TLQSYEEKVLKVGgsqkn-----lsniNLSFSPQHGTGAKIVKSIFKKlnvn--------affE 220 Mycoplasma mobi...
Feature 1                                                   # # ##                               
AAH10087     279 PEQKDPDPEFPTVKYPNPEEgKGVLTLSFALadktkaRIVLANDPDADRLAVAEkqdsgeWRVFSGNELGALLGWWlfts 358 human
14248265     284 DAQCKPDPNFSSVQSANPED-HRAFDQAVELankshaDLLISTDPDADRLGIAErdahghITYFNGNQIGALLLNYriqq 362 Staphylococcus ...
YP_301827    247 KEQSEPNGNFPTVAIANPED-EAAFTLGKQLadktdaQLIIATDPDADRLGFIErygdndFRYFNGNEIGLLLMKLrfqd 325 Staphylococcus ...
NP_757495    267 AQQCVPDPNFTYSANFNPED-KASFDLSLKYaekyraNIMLGVDPDSDRLAVVVrhk-nkWHYLTGNQMGIIFTHYvltn 344 Mycoplasma pene...
NP_853364    268 KEQCKYDENFTYTKSPNPEA-RESWDLALKYaqhygaDIMLATDPDADRLAVAVkhn-neFRYFNGNEMGIIFAYYilky 345 Mycoplasma gall...
1352196      255 EEQCIFDGNFSNTPTPNPEN-RAAWDLSIEYadknnaNVIIQVDPDADRFALGVryk-nsWRFLSGNQMGIIYTDYilkn 332 Mycoplasma pirum
NP_072713    258 EEQNWFDENFENAPNLNPEY-KDTWILAQKYakknnaKLIIMADPDADRFAIAElnn-nqWHYFSGNETGAITAYYklnh 335 Mycoplasma geni...
6899534      256 SEQNFEDPNFNDDPSSNPEE-QCSFDLSVEYadntnaEIMIASDPDGDRMAIAVrhe-nyWKFLTGNQTGVLIAHYlleh 333 Ureaplasma parv...
YP_001256604 233 KEHMKIDANFKYVQYPNPEK-HSAYELLIKLgkqkdaDILLMSDPDSDRVGLAVkhs-deYRILNGNETAIIVFKFlldl 310 Mycoplasma agal...
YP_015960    221 EAQMKNDPDFTHTKSPNPED-KSSYENVIKLglihksDAVLITDPDADRVGIGIlrn-neYILLNGNETATLIFNYliei 298 Mycoplasma mobi...
Feature 1                            #                    ###                       # # #        
AAH10087     359 wkeknqdrsalkdtYMLSSTVSSKILRAIALKEgFHFEETLTGFKWMGNRakqli--dqgktVLFAFEEAIGYMCCpf-v 435 human
14248265     363 ts-------qlrhrLMIQSIVSSELTKSLARYNnVKYKEVLTGFKFIAQEirqld---dhqnMIFAFEESYGFLSEpf-v 431 Staphylococcus ...
YP_301827    326 lt------edstpqYMIKSIVTSELAERLATSLnVEVNDVLTGFKFISDLiehkqk-dddkqLLLAFEESHGYLAQpi-s 397 Staphylococcus ...
NP_757495    345 kk-------fdktpFVVSTFVSTNYIDRIAEKYnAKVFRTPTGFKWVGNEmnkhi---dkmdFVVGFEEAIGSLNSdi-g 413 Mycoplasma pene...
NP_853364    346 kq-------ltkrpYIVSSYVSTNLIDRIIAKYnGVVYRVGTGFKWIGNKaidhk---dqedFILGFEEAIGALPTti-g 414 Mycoplasma gall...
1352196      333 kt-------ftkkpYIVSSYVSTNLIDRIIKEYhGEVYRVGTGFKWVGDKinkik---dseeFVVGFEEAVGALNSti-n 401 Mycoplasma pirum
NP_072713    336 k--------vfkspYIVSTFVSTYLVNKIAKRYgAFVHRTNVGFKYIGQAinels---qtneLVVGFEEAIGLITSdkln 404 Mycoplasma geni...
6899534      334 kk-------ftkptYIISTFISTRYPELFAKNFdCDVLYVDVGFKNHGNLianrk---kthnLVVGFEEAIGSLPSdi-n 402 Ureaplasma parv...
YP_001256604 311 vkst---ikqpnnhYIVYSFVSTNIPEILALSEgIKSVVVPTGFKWIGKIinefs--negkkFMFAFEESYGSLIDenls 385 Mycoplasma agal...
YP_015960    299 ne------nklqdkYLIYSFVSSSLPKKMAIENnIKWYEVATGFKYIGNLieqiknesktskLLFAFEESYGSLINdsla 372 Mycoplasma mobi...
Feature 1                                                                                        
AAH10087     436 LDKDGVSAAVISAELASFlat-knlSLSQQLKAIYVEYGYHITKASyfic-----hdqETIKKLFENLRNYDgknnypka 509 human
14248265     432 RDKDAVQIVPLIIKYASElkl-ygkTLKDELEQIYQTVGRHEDTLFshtle--glegkKKIESIMTHFRSNPpqeiqglk 508 Staphylococcus ...
YP_301827    398 RDKDAIQMVPLLVKYKNLldk-ngiTFKETIEDIYENIGYFKDRTLaptfe--gkagvKKIESIMSQFRNEQvfsicgmd 474 Staphylococcus ...
NP_757495    414 RDKDGFQAAALALEVYTMlyd-qekTLVDYLDEIFEEFGAWTGETVsykie--slnwkEEMQEKMDKFANVKnkdilgle 490 Mycoplasma pene...
NP_853364    415 SDKDSFQTAALALEIYNEclkrkitMVDFLEREIYPQFGFIHNDTIttlin--dldwkKKANDWMERLKRYDqpyindrk 492 Mycoplasma gall...
1352196      402 RDKDAYQAAALALEIYNEclknninIIDHLEKNIYGKYGIIHNDTIsftfv--ennwkELVKKSLDKILKYSektignrt 479 Mycoplasma pirum
NP_072713    405 REKDAYQAAALLLEIARHcke-qniTLLDFYKRILSEFGEYFNLTIshpfkatatdwkEEIKALFNQLINANltevagfk 483 Mycoplasma geni...
6899534      403 NDKDSYQTASILLEMINYyyeqkldLFTVLKKEIFAKYGNWYSKTTqfvid--gdnwkQKALIILNNLRNFEfktvtqyt 480 Ureaplasma parv...
YP_001256604 386 RDKDALQSIAILTKMASYykk-qnkTLIDILNEVYETVGYVASENIeievd--estdlALLQEKFKNLNFENkiiedfnl 462 Mycoplasma agal...
YP_015960    373 YDKDAIQSCVILAKMISFykk-kskTLLDVLEDIYKKYGYIKSESFsinldeknplhlENIQSKFINLKFNEdfkienfi 451 Mycoplasma mobi...
Feature 1                                                         # ###    #                     
AAH10087     510 cgkfeisairdlttgyddsqpdkkavlptskssQMITFTFAn-gGVATMRTSGTEPKIKYYAELcapp-------gnsdP 581 human
14248265     509 vkaiedylts-----evyhldkdttsqinssksNVIRVLFDe--GFIALRPSGTEPKIKLYVSLkc-----------pdF 570 Staphylococcus ...
YP_301827    475 vlkiedyhvg-----evrdmitghtekltlpktNLIRFIFEn--GFIALRPSGTEPKIKLYFSLe--------------V 533 Staphylococcus ...
NP_757495    491 i-----------------------kgirwnepaQALEWYLEn-dMWVKFRLSGTEPKFKIYYEIyg-----------etK 535 Mycoplasma pene...
NP_853364    493 i-----------------------vsikwnqagDCLDWILEd-dSWIRFRLSGTEPKFKFYYNLyg-----------nsL 537 Mycoplasma gall...
1352196      480 i-----------------------tsikynevgGCYDWILDg-dSWLRFRMSGTEPKFKVYYNLyg-----------enL 524 Mycoplasma pirum
NP_072713    484 v-----------------------vkvhldkqtNILEFGFEn--GWVKFRFSGTEPKLKFYFDLtn-----------gtR 527 Mycoplasma geni...
6899534      481 i-----------------------hniifheqgSYLEWKLDe-ySTIKFRLSGTEPKFKVYIDLydfskdqkrdfyqelK 536 Ureaplasma parv...
YP_001256604 463 --------------------------kssfmksNMIQIKFKndnSWLALRPSGTEPKIKFYVFAfd-----------ktI 505 Mycoplasma agal...
YP_015960    452 k------------------------gkeniapsNMIRISFQn-lNWIALRPSGTEAKIKFYLYVvd-----------kdK 495 Mycoplasma mobi...
Feature 1                    
AAH10087     582 EQLKKELNELVS 593 human
14248265     571 DDVAQKINAMIF 582 Staphylococcus aureus subsp. aureus Mu50
YP_301827    534 ENIDEITQQFEA 545 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
NP_757495    536 EICDQILKALKD 547 Mycoplasma penetrans HF-2
NP_853364    538 KQLKEEANQITK 549 Mycoplasma gallisepticum R
1352196      525 NALSQEAKTIND 536 Mycoplasma pirum
NP_072713    528 EALEKQAKKIYK 539 Mycoplasma genitalium G37
6899534      537 IKAEDILDFLKN 548 Ureaplasma parvum serovar 3 str. ATCC 700970
YP_001256604 506 DLAQQKLNKFKE 517 Mycoplasma agalactiae PG2
YP_015960    496 ILVEKNWNILKE 507 Mycoplasma mobile 163K

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