2NN6


Conserved Protein Domain Family
S1_CSL4
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cd05791: S1_CSL4 
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S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. ScCSL4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in eukarytes and archaea. Its functions include the removal of incorrectly processed RNA and the maintenance of proper levels of mRNA, rRNA and a number of small RNA species. In S. cerevisiae, the exosome includes nine core components, six of which are homologous to bacterial RNase PH. These form a hexameric ring structure. The other three subunits (RrP4, Rrp40, and Csl4) contain an S1 RNA binding domain and are part of the "S1 pore structure".
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Statistics
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PSSM-Id: 240217
Aligned: 18 rows
Threshold Bit Score: 131.214
Created: 17-Dec-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RNA bindingsubunit
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:RNA binding residues of the RNA PolymeraseII RPB7 subunit, confirmed by mutagenesis
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #       #         # #                                             
2NN6_I        76 QLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSfrGTIRKEDVratek---dkveiYKSFRPGDIVLAKVISLgda 152 human
NP_588510     52 AVLPNVGSIVLARVSRINARQATVNISVVDDVCTKDEfqGVIHVQDIratek---nkvkvQNSFRPGDIVRALVISLgdg 128 Schizosaccharom...
NP_568559     64 GPIPETGSVVIARVTKVMTKMAAVDILCVGSKAVRENfaGVIRQQDVratei---dkvdmHQSFHAGDIVRAMVLSLgda 140 thale cress
XP_570404     60 VGTVDVDSIVIGVISRLTPQQAHMTLTTLSDRPLPESseDFTGLIRIadirlterdkvkmGECFRLGDIVKAKVLSLgda 139 Cryptococcus ne...
XP_954420     54 VKIPYVGATVIAQITRVHINKADCNIISVDGRVLKDFfkGSLTNNNVleskn---ieilmYEWFRPGDFIKCKVIYAgdg 130 Theileria annul...
XP_961311     88 EVLPEVGNIVLCRVIRIMPRQAVVAILICGDTVLEAEwqGLIRVQDVratek---drvkiYDSFRPGDIVRAEVISLgdq 164 Neurospora cras...
EAT82671      87 PILPEVDSTVLARITRLGARFATCEILVIGDTVCREAfqGQIRREDIratek---dkikiEESFRVGDLIRGVVISLgdq 163 Phaeosphaeria n...
CAL54451      53 LVVPRVGDDVHGRVLRVLERAAHVDIAAINGRAPVGGgfAGTIRRQDvrahav--dsvelDRCFRAGDVVRAKVLSLgda 130 Ostreococcus tauri
CAK85459      54 DPELKIGAIIIGQVNSIREDRVFVRILKINGVKVNNYieGVLRKQNIrshei---dllemNKCYLPGDIIKARMISYgds 130 Paramecium tetr...
XP_001610372  24 SSIPAVGAIVIAQVQRISHQQAECCIVCLEGRSIPEGlkGVISLSNIyqska---iepkiYECFHPGDFVRAKVISTsdt 100 Babesia bovis T2Bo

Feature 1                        
2NN6_I       153 qsnYLLTTAenELGVV 168 human
NP_588510    129 -ssYFLTTArnDLGVI 143 Schizosaccharomyces pombe 972h-
NP_568559    141 -raYYLSTAknELGVV 155 thale cress
XP_570404    140 -rsYYLSTAadELGVV 154 Cryptococcus neoformans var. neoformans JEC21
XP_954420    131 -kqFTLSTAglGLGVI 145 Theileria annulata strain Ankara
XP_961311    165 -asYYLSTArnELGVI 179 Neurospora crassa OR74A
EAT82671     164 -snYYVATDrnEFGVV 178 Phaeosphaeria nodorum SN15
CAL54451     131 -rsFYLTTAsdELGVV 145 Ostreococcus tauri
CAK85459     131 -lkLYLSTAedELGVL 145 Paramecium tetraurelia
XP_001610372 101 -kqLMLSTAqkDLGVI 115 Babesia bovis T2Bo

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