Conserved Protein Domain Family
LbH_eIF2B_epsilon

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cd05787: LbH_eIF2B_epsilon 
eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is important for regenerating GTP-bound eIF2 during the initiation process. This event is obligatory for eIF2 to bind initiator methionyl-tRNA, forming the ternary initiation complex. The eIF-2B epsilon subunit contains an N-terminal domain that resembles a dinucleotide-binding Rossmann fold, a central LbH domain containing 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), and a C-terminal domain of unknown function that is present in eIF-4 gamma, eIF-5, and eIF-2B epsilon. The epsilon and gamma subunits form the catalytic subcomplex of eIF-2B, which binds eIF2 and catalyzes guanine nucleotide exchange.
Statistics
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PSSM-Id: 100061
View PSSM: cd05787
Aligned: 21 rows
Threshold Bit Score: 117.294
Threshold Setting Gi: 57222940
Created: 27-Nov-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAH13590   361 LLGSGTVIGSNCFITNSVIGPGCHIGDNVVLDqTYLWQGVRVAAGAQIHQSLLCDnAEVKErVTLKPRSVLTSQVVVGP 439  human
CAB16302   332 LIGAYTKVGDASVVANTIIGRNCTIGSNCSIDsAFLWEDVVIGDNCRIGKAILANsVKIGNnCSIEDGAIVAAGVVIGD 410  fission yeast
XP_500943  338 LVGRGTSVGERSMVKDTVIGRDCKISTNVNLVdSFIWSNVIIEDDVTVNGGLVADgAILKKgCSVGPGSIIGHGVTVEE 416  Yarrowia lipolyti...
NP_193564  339 VIGYGTKIGNGGKIYNSVIGNGCCIGSNVVIQgSYIWNNVTIEDGCEIRNAIVCDgVKVRAgAVLQPGVVLSFSVVVGR 417  thale cress
EAZ25042   541 VVGNGTSVGENCKVSNSVIGQGCNIGKNVLIHgSYIWDNVTIEDGCKVSNSLVCDgVHLGAgAIVEPGCILSFKVEVGK 619  Japanese rice
XP_751131  407 VIGKGTSIGDKTTVKNTVLGRDCKIGKNVTLDgAYIWDGVVIGDGTTVRQAIIADkVVVGKnCSVKPGALLSYEVRIAD 485  Aspergillus fumig...
EAT89427   322 VIGRGTSIGDKTVIKNSIIGRHCQIGRNVKLDgAFIWDYASVGDGSTISKSVIANeASIGRkCTVEDGALISYGVTIGE 400  Phaeosphaeria nod...
XP_422755  347 LIGQGTVIGSNCSIMNSVIGQNCRIGDEVTLDgAFLWDGVHVADNVQIHHSVICDeAEVKEkVKLKPHCVLSSQVVVGP 425  chicken
XP_784928  822 VIGPGSHIGVNTRVTHSVIGRNCKIGDNVVLEnAYIWDNVTIEANCHINMALLCDsVHVKSeVTIKNGCVLSFGVKVGP 900  purple urchin
EAS36383   350 IIGTGTNIGEGTYITDSVIGRRCRIGNNVILDgAYIWDDVVIGDGTEIRHAIVANgVVIGSkCRVEPGVLLSYGVKLGD 428  Coccidioides immi...
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