Conserved Protein Domain Family
DNA_polB_zeta_exo

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cd05778: DNA_polB_zeta_exo 
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
The 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta. DNA polymerase zeta is a family-B DNA polymerase which is distantly related to DNA polymerase delta. It plays a major role in translesion replication and the production of either spontaneous or induced mutations. In addition, DNA polymerase zeta also appears to be involved in somatic hypermutability in B lymphocytes, an important element for the production of high affinity antibodies in response to an antigen. The catalytic subunit contains both polymerase and 3'-5' exonuclease domains, but only exhibits polymerase activity. The DnaQ-like 3'-5' exonuclease domain contains three sequence motifs termed ExoI, ExoII and ExoIII, without the four conserved acidic residues that are crucial for metal binding and catalysis.
Statistics
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PSSM-Id: 99821
View PSSM: cd05778
Aligned: 31 rows
Threshold Bit Score: 165.486
Threshold Setting Gi: 86563326
Created: 1-Oct-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O60673       2294 IQNLTLISVELHa-RTRRDLEPDPEFDPICALFYCISSDTPLPDtek-----teLTGVIVIDKDktvfsqdiryq----- 2362 human
XP_001011832  860 HEDITMYTFEIFa-KSTPDMLPDPSSDPINFIVFDLENFKRTQGi--------iLVDEINCHEPidkvrky--------- 921  Tetrahymena t...
XP_001424691  653 QEDLVLMIFEIFs-YKDSKLLPDPEKDEISFIILHSYNVKSSKIm--------nKMLIIQNEENylkavngy-------- 715  Paramecium te...
XP_001612136  529 DNFESGIVIDVIteSEPNKVYPDPLVHSILAVVYTKRDHRLVQRfqelglpyadVQGAIIVDPLksgtkkqdrakltgfn 608  Babesia bovis...
XP_001646204  662 HDVLTHFTLEVHt-DNIGSKFPDPKNDSVRLIAWKIDDETYPFQld------vaSEGFMIFCGPetevsnyhl------- 727  Vanderwaltozy...
XP_452640     612 SNRMTHFTMEIHv-NTREDKFPDPKYDAVRMIFWKVQDGTFPFDld------itQEGVLIFLDDvstens---------- 674  Kluyveromyces...
NP_015158     664 HDSLTHLTLEIHa-NTRSDKIPDPAIDEVSMIIWCLEEETFPLDld------iaYEGIMIVHKAsedstfpt-------- 728  baker's yeast
NP_982443     624 GPQLLHLSMEIHv-DTRRNMLPNPRTDEIKMICWSIDGPQSVGTme-------lSTDGLLVSLNendaiykr-------- 687  Ashbya gossyp...
XP_449434     645 HDNLTHFSLEIHv-NTRGDLLPDPRKDEVSVIFWKVDSDTFPFSid------lqLEGIMYTNKLerenlie--------- 708  Candida glabr...
XP_502101     525 SAALTVMSMEVHv-NTRKGLNPDPDLDPILFVVWHMLGGPSGVIi--------nAEDCPDFTNIi--------------- 580  Yarrowia lipo...
O60673       2363 -------------tpllirsgitGLEVTYAADEKALFHEIANIIKRYDPDILLGYEIqMHSWGYLLQRAAALSidlc-rm 2428 human
XP_001011832  922 ----------------ygfndsmFKTIIVTKNEEELLLTFIKQIHIFNVDIITGWDIeKKSLFYFSHRCWQLGidvm-di 984  Tetrahymena t...
XP_001424691  716 ---------------fermnapvEYTIVLTQNEINLMKAFTLIVHLIDPDFISGYDLeTRSLYYVANRAEFIGydfl-te 779  Paramecium te...
XP_001612136  609 rfamvqrkninmdtieriinsqkYINVAYVQSERELIQEVENLFIKFDPNIIYGYDVaRSSIGYIQHRAAAIGvpdfler 688  Babesia bovis...
XP_001646204  728 ---------------krieqaagSSAIGFYETEIDMFDALIDLILFFDPDILSGFEVqSASWGYLIDRYRFIQkesllee 792  Vanderwaltozy...
XP_452640     675 -----------------wktadpSVHITAYYDELEMIYALEDLVRFFDPDILSGYEIhSSSWGYLIDRCHKGHdydvede 737  Kluyveromyces...
NP_015158     729 ----------------kiqhcinEIPVMFYESEFEMFEALTDLVLLLDPDILSGFEIhNFSWGYIIERCQKIHqfdivre 792  baker's yeast
NP_982443     688 ----------------iieeacgKTRVAFFTSEYELITEFAKLVLIIDPDILQDMNH-KSSWGYILARVELSHnidfgll 750  Ashbya gossyp...
XP_449434     709 ----------------tlesisgGVPIMEYEDEFSMFDALTDLILLFDPDLLSGYEIhNSSWGYIFERSLSVHkfniane 772  Candida glabr...
XP_502101     581 -----------------------EAPSTVVKTECEMITHLQKMVENFDPDILTGFEVqASSWGYVQDRCKTMLypc---e 634  Yarrowia lipo...
O60673       2429 iSRVPDDKienrfaaer------------------------------------------------------deygsytmS 2454 human
XP_001011832  985 lSRCPKNSfnilrafkladclieeqfqndsakgysqqsmsf-----dsnqsfklqnvamqsikqshrsakqtgffanfkL 1059 Tetrahymena t...
XP_001424691  780 iSRGQPTYdklieifdideilfnfgqpqpineklqkymdyrmqrptaskkqsfnqdaktksynskgklnqinsrrkklrF 859  Paramecium te...
XP_001612136  689 iSRVPPKHerqitdittimthq-------------------------------------------naklikgryksssiK 725  Babesia bovis...
XP_001646204  793 lSRVSIDEasryidk----------------------------------------------------------wgsnrsS 814  Vanderwaltozy...
XP_452640     738 lSRVDYNQsskkkdr----------------------------------------------------------wgythaT 759  Kluyveromyces...
NP_015158     793 lARVKCQIktklsdt----------------------------------------------------------wgyahsS 814  baker's yeast
NP_982443     751 iSRLSRDDrsglase----------------------------------------------------------wnyshsA 772  Ashbya gossyp...
XP_449434     773 iSRVNMGAqfklrds----------------------------------------------------------wgfkksS 794  Candida glabr...
XP_502101     635 fGRVQHHKmsskidt----------------------------------------------------------wgarkaS 656  Yarrowia lipo...
O60673       2455 EINIVGRITLNLWRIMRNEVaLTNYTFENVSFHVLhQRFPLFTFRVLSdwf---------------------dnKTDLYR 2513 human
XP_001011832 1060 NFEIAGRMIINTWRLVKHDYkLFCYELESVVNYVFqERIPIFSNWSLTqmy---------------------nhEDIKQR 1118 Tetrahymena t...
XP_001424691  860 ITFVVGRVLINVWRNVATDIkIIDYSIENVYFQMFkQKNALIHNQTLSq-------------------------WFKSET 914  Paramecium te...
XP_001612136  726 PVFCLGRLIFDLADVALRELnLANLTLENIVYNQFdYLMPVYSQYTLSkwlttsvqlnasndpsattesapkhgSYKPHA 805  Babesia bovis...
XP_001646204  815 GVKVTGRHIINIWRAMRASTnFNQYTIENLCSKLLnKRLPHFSFSDLSkmw---------------------ngNDVTEI 873  Vanderwaltozy...
XP_452640     760 AFSITGRQMLNIWRPLRSSLnLLDYTLENIAFHVLhQRLPFYSYKTRTefy---------------------esMDETSK 818  Kluyveromyces...
NP_015158     815 GIMITGRHMINIWRALRSDVnLTQYTIESAAFNILhKRLPHFSFESLTnmw--------------------nakKSTTEL 874  baker's yeast
NP_982443     773 GIKIAGRHMLNVWRKMRTEVnLAKYNIENVAYHLLhERLPKFTHETLSgfw--------------------rtkSDRTSI 832  Ashbya gossyp...
XP_449434     795 GISITGRYVLNIWRLLRKEIaVTQYSFENMVHLLLkIRLPKYSCSHLTslw--------------------snfKTGNEL 854  Candida glabr...
XP_502101     657 GVKVVGRHVLNLWRMIRGEVsLLKYTLENVVFHVLhERIPFYTHDTLTem----------------------cvGSLSDR 714  Yarrowia lipo...
O60673       2514 WKMVDHYVSRVRGNLQMLE 2532 human
XP_001011832 1119 VFVFEYMMKRLMKTKDIID 1137 Tetrahymena thermophila SB210
XP_001424691  915 FLVFQYYAKRINMTFDILE 933  Paramecium tetraurelia strain d4-2
XP_001612136  806 YRAIRYMLFRNYAVLATMD 824  Babesia bovis T2Bo
XP_001646204  874 KTVMSYWMTRVRCNMLLLK 892  Vanderwaltozyma polyspora DSM 70294
XP_452640     819 RCLLFYWITRLRVNFKLLE 837  Kluyveromyces lactis NRRL Y-1140
NP_015158     875 KTVLNYWLSRAQINIQLLR 893  baker's yeast
NP_982443     833 KIVINYCLERVRCNIRLLN 851  Ashbya gossypii ATCC 10895
XP_449434     855 KTFLNYYLTRVRLNIGILK 873  Candida glabrata CBS 138
XP_502101     715 KLLVEYKCTRSNYNLQLLS 733  Yarrowia lipolytica CLIB122
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