1PY4,1A1M,1P4L


Conserved Protein Domain Family
IgC1_beta2m

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cd05770: IgC1_beta2m 
Class I major histocompatibility complex (MHC) beta-2-microglobulin; member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the immunoglobulin-like domain in beta-2-microglobulin (beta2m). Beta2m is the non-covalently bound light chain of the human class I major histocompatibility complex (MHC-I). Beta2m is structured as a beta-sandwich domain composed of two facing beta-sheets (four stranded and three stranded), that is typical of the C-type immunoglobulin superfamily. This structure is stabilized by an intramolecular disulfide bridge connecting two Cys residues in the facing beta-sheets. In vivo, MHC-I continuously exposes beta2m on the cell surface, where it may be released to plasmatic fluids, transported to the kidneys, degraded, and finally excreted.
Statistics
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PSSM-Id: 409427
View PSSM: cd05770
Aligned: 7 rows
Threshold Bit Score: 151.476
Threshold Setting Gi: 147904734
Created: 26-Jul-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:MHC classI alpha interface [polypeptide binding site]
Evidence:
  • Structure:1P4L; murine beta2m binds MHC class I alpha chain, defined using 3.5 A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             # ###           # # #                         ####   # ##                  
1PY4_A         4 RTPKIQVYSRHPAENGKSNFLNCYVSGFYPSDIEVDLLKNGERIek-vEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACR 82  human
1A1M_B         3 RTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIek-vEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACR 81  human
1P4L_B         3 KTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIpk-vEMSDMSFSKDWSFYILAHTEFTPTETDTYACR 81  Mus musculus
416695        22 STPKVHVYSHFPGEYGKPNTLICYVSSFHPPDISIELLKNGQVMsd-tKQTDLAFEKGWQFHLTKSVAFTPEKGDEYTCS 100 zebrafish
P21611        23 LTPKVQVYSRFPASAGTKNVLNCFAAGFHPPKISITLMKDGVPMeg-aQYSDMSFNDDWTFQRLVHADFTPSSGSTYACK 101 chicken
CAM73243     117 VRPSVIMYAEFPEEEGKANVLYCYATGFYPGDIDIRFFLNGQKStaklETSDLMYGEDWTFRVFKYMKITPQTGDEYTCE 196 zebrafish
NP_001082000  21 SPPVVKVYTAEPVDFGKTNEVICYVYNYHPPRLEMRLEKNGVEIpd-cKQTDPSFQHNWKYYTTKSTHVHIDKGDKVECV 99  African clawed ...
Feature 1                       
1PY4_A        83 VNHvtlsQPKIVKWD 97  human
1A1M_B        82 VNHvtlsQPKIVKWD 96  human
1P4L_B        82 VKHasmaEPKTVYWD 96  Mus musculus
416695       101 VRHm--kETKKFSWE 113 zebrafish
P21611       102 VEHetlkEPQVYKWD 116 chicken
CAM73243     197 VRHssmsEPKITVWR 211 zebrafish
NP_001082000 100 VSHng-nPSKKYRLD 113 African clawed frog

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