1FYT,1KGC,1NFD,2AK4,2F53,2PYF


Conserved Protein Domain Family
IgC1_TCR_beta

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cd05769: IgC1_TCR_beta 
T cell receptor (TCR) beta chain constant immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the T cell receptor (TCR) beta chain constant immunoglobulin domain. TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the beta chain. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The antigen binding site is formed by the variable domains of the alpha and beta chains, located at the N-terminus of each chain. Alpha/beta TCRs recognize antigens differently from gamma/delta TCRs.
Statistics
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PSSM-Id: 409426
View PSSM: cd05769
Aligned: 15 rows
Threshold Bit Score: 157.539
Threshold Setting Gi: 1929972
Created: 27-Jun-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1FYT; human T-cell receptor alpha/beta heterodimer interface between constant domains of alpha chain and beta chain, defined using 4.0 A contacts.
    View structure with Cn3D
  • Citation:PMID 9768757
  • Structure:1NFD; murine T-cell receptor alpha/beta heterodimer interface in IgC domains, defined using 4.0 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # ## #              # # # #                    ### ##  #           # # # ##
1FYT_E    118 FPPEVAVFEPSeaeis----htqkATLVCLATGFFPDHVELSWWVNGKEVhsGVSTDPQPLKeqpalndsrYSLSSRLRV 193 human
1NFD_B    119 TPPKVSLFEPSkaeia----nkqkATLVCLARGFFPDHVELSWWVNGKEVhsGVSTDPQAYKesn----ysYSLSSRLRV 190 house mouse
2PYF_B    118 FPPEVAVFEPSeaeis----htqkATLVCLATGFYPDHVELSWWVNGKEVhsGVCTDPQPLKeqpalndsrYALSSRLRV 193 human
AAA62753  129 IEPDVVIFSPSkqeiq----ekkkATLVCLASGFFPDHLNLVWKVNGVKRteGVGTDEISTSng-----stYSLTSRLRI 199 chicken
S31618     18 TQPSVVLFDPSpqeik----kkgkATLVCLATNFYPDHVTLRWSVNDQVTttGVKTDDSPIRgsd----rmYSLSSRLRL 89  axolotl
AAG46046   28 PPTKVEIFPPSakecrnqkdnkrkKTLVCVASGFYPDHVSVSWKKNGNGVkdGVATDSAAKRtd-----ktYRITSRLRV 102 bicolor damselfish
AAK11214    7 REPTVVMFNPSeleir----ekrkATLVCLATNFYPGHVTISWSVNGQNRtkGVKTDDDAAHeet---trmYSMSSRLRV 79  axolotl
AAL58477    6 TNPTVKLLPPSpdelcyaqknrekVTLVCLATDFYPDHVSITWQVNGKEKknNVATDHVAQQans---tslYSMSSRLRV 82  channel catfish
BAD89511    6 KEPDVEILKPSeietg----ckkrVTLVCVAKDFYPDHVSIRWSLGSEEIkdDVATDPYALQdnt---tklFSISSRLQI 78  Carassius auratus ...
BAE16831    6 TGPTVTLLPPSsrecrnqkhqkrkKTIVCVASGFYPDHVSVSWEVNGQKVtdGVATDGAALRpeg----rfYRISSRLRV 81  torafugu
Feature 1                                                    
1FYT_E    194 satfWQNPRNHFRCQVQFYGlsendew---tqdrakpVTQIVSAEAW 237 human
1NFD_B    191 satfWHNPRNHFRCQVQFHGlseedkw---pegspkpVTQNISAEAW 234 house mouse
2PYF_B    194 satfWQDPRNHFRCQVQFYGlsendew---tqdrakpVTQIVSAEAW 237 human
AAA62753  200 saqeWFNPLNRFECIANFFKngtqqsi---qkiiygdTGCDIFKENY 243 chicken
S31618     90 tkmdWMNPHNTFRCSVYFDPenitvs-----retkgrEGCGVTEDSF 131 axolotl
AAG46046  103 paddYNKLGNTFTCIVSFYDgekttp-----ynksidSIQGKSEGGM 144 bicolor damselfish
AAK11214   80 streWFDVRNTFQCTVDMYYaterdiv----kyitggKECGLDKESY 122 axolotl
AAL58477   83 dqieWTNIKNNFTCIVTFYNghdylmfq--snikfspAKIPPRVYNT 127 channel catfish
BAD89511   79 pk-kEFKPKHNYTCTVKYYYetdqskn----vsssiiGIEGDEYEPE 120 Carassius auratus langsdorfii
BAE16831   82 saedWFRPDSDFTCIISFFNgtstelysaslqgeaaaATEVMSRETY 128 torafugu

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