5XWT,5XWT


Conserved Protein Domain Family
IgI_SALM5_like

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cd05764: IgI_SALM5_like 
Immunoglobulin domain of human Synaptic Adhesion-Like Molecule 5 (SALM5) and similar proteins; member of the I-set of IgSF domains
This group contains the immunoglobulin domain of human Synaptic Adhesion-Like Molecule 5 (SALM5) and similar proteins. The SALM (for synaptic adhesion-like molecules; also known as Lrfn for leucine-rich repeat and fibronectin type III domain containing) family of adhesion molecules consists of five known members: SALM1/Lrfn2, SALM2/Lrfn1, SALM3/Lrfn4, SALM4/Lrfn3, and SALM5/Lrfn5. SALMs share a similar domain structure, containing leucine-rich repeats (LRRs), an immunoglobulin (Ig) domain, and a fibronectin III (FNIII) domain, followed by a transmembrane domain and a C-terminal PDZ-binding motif. SALM5 is implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons. SALM5 interacts with the Ig domains of LAR (Leukocyte common Antigen-Related) family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPdelta, and PTPsigma). In addition, PTPdelta is implicated in ASDs, ADHD, bipolar disorder, and restless leg syndrome. Studies have shown that LAR-RPTPs are novel and splicing-dependent presynaptic ligands for SALM5, and that they mediate SALM5-dependent presynaptic differentiation. Furthermore, SALM5 maintains AMPA receptor (AMPAR)-mediated excitatory synaptic transmission through mechanisms involving the interaction of SALM5 with LAR-RPTPs. This group belongs to the I-set of immunoglobulin superfamily (IgSF) domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.
Statistics
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PSSM-Id: 409421
View PSSM: cd05764
Aligned: 11 rows
Threshold Bit Score: 169.964
Threshold Setting Gi: 41055379
Created: 19-Jul-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:PTPdelta binding site [polypeptide binding site]
Evidence:
  • Structure:5XWT; Human SALM5 LRR-Ig in complex with PTPdelta Ig1-Fn1, contacts by 4A
    View structure with Cn3D
  • Comment:SALM5 interacts with the Ig domains of LAR (Leukocyte common Antigen-Related) family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPdelta, and PTPsigma).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               # #       #      #                                  ### #
5XWT_B       270 PLITrh-tHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGE 348 human
5XWT_D       270 PLITrh-tHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGE 348 human
Q8BXA0       287 PLITrh-tHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGE 365 house mouse
NP_956909    288 PLITkhqvTKPYVMEGQGVTLKCKAMGDPDPAIHWRFPDGKLVHNNSRTILYDNGTLDILITTLKDSGAFNCVASNAAGI 367 zebrafish
CAF94007     288 PVLTrk-sPHTVAMEGQPASLKCKANGDPEPEVHWISPEGRLISNTSRTLVFPNGSLDINTTSVKDSGNFTCIASNAAGE 366 Tetraodon nigro...
CAF99016     299 PLITqh-tHKLLVLEGQTASLRCKAVGDPMPTVHWVAPDDRLISNSSRATVYENGTLDITITTSKDYGIFTCIAANAAGE 377 Tetraodon nigro...
Q6PJG9       281 PLIArh-tQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGE 359 human
Q96NI6       287 PLITrh-tHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGE 365 human
XP_421485    287 PLITrh-tHELRVLEGQRAALRCKARGDPEPAIHWISPEGKLISNATRSVVYDNGTLDILITTVKDTGSFTCIASNPAGE 365 chicken
NP_001088811 289 PLITrh-tHQLWVLEGQRATLKCRAIGDPEPVIHWVSPDDKIMPNSSRTASYRNGTLDILVTTIRDDGSYTCIAINAAGE 367 African clawed ...
CAP07992     287 PLITrh-sHEMRVLEGQRVALKCKARGDPEPAIHWISPEGKLVSNTSRTLVYNNGTLDILISTVKDTGSFTCISSNPAGE 365 zebrafish
Feature 1                 
5XWT_B       349 ATQIVDLHI 357 human
5XWT_D       349 ATQIVDLHI 357 human
Q8BXA0       366 ATQTVDLHI 374 house mouse
NP_956909    368 ATAAVHVHM 376 zebrafish
CAF94007     367 STGRVELVV 375 Tetraodon nigroviridis
CAF99016     378 STASIELSI 386 Tetraodon nigroviridis
Q6PJG9       360 ATARVELRV 368 human
Q96NI6       366 ATQIVDLHI 374 human
XP_421485    366 ATQTVDLHI 374 chicken
NP_001088811 368 STAQVDLKM 376 African clawed frog
CAP07992     366 AHQTIELVI 374 zebrafish

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