Conserved Protein Domain Family
Ig2_PTK7

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cd05760: Ig2_PTK7 
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7
The members here are composed of the second immunoglobulin (Ig)-like domain in protein tyrosine kinase (PTK) 7, also known as CCK4. PTK7 is a subfamily of the receptor protein tyrosine kinase family, and is referred to as an RPTK-like molecule. RPTKs transduce extracellular signals across the cell membrane and play important roles in regulating cell proliferation, migration, and differentiation. PTK7 is organized as an extracellular portion having seven Ig-like domains, a single transmembrane region, and a cytoplasmic tyrosine kinase-like domain. PTK7 is considered a pseudokinase as it has several unusual residues in some of the highly conserved tyrosine kinase (TK) motifs; it is predicted to lack TK activity. PTK7 may function as a cell-adhesion molecule. PTK7 mRNA is expressed at high levels in placenta, melanocytes, liver, lung, pancreas, and kidney. PTK7 is overexpressed in several cancers, including melanoma and colon cancer lines.
Statistics
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PSSM-Id: 409417
View PSSM: cd05760
Aligned: 4 rows
Threshold Bit Score: 193.991
Threshold Setting Gi: 153792686
Created: 17-Aug-2007
Updated: 17-Aug-2020
Structure
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Aligned Rows:
 
Feature 1:Ig strand B [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           #####                                                         
Q13308        128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHs-aF 206  human
XP_001364746  129 PVILKHPASLAEIQPQTLVTLRCHIDGHPRPTYQWFRDSNPLSDSQGNYSVSSKERNLTLRRASPEHSGVYSCCAHn-sF 207  gray short-ta...
NP_001026206  115 SVVLKQPASAAEIQPSSTVVLRCHIDGHPRPTWQWFRDGAPLPDGRGTYSVSSKERTLTLRGAGPDDNGLYYCSARpraV 194  chicken
NP_001093383  117 RVTLQDPASASDIQSSSRVTLRCHIDGHPRPICHWFRDGTPLADDGQATSLSNKERTLTLHSAGADDSGEYYCCAHn-aA 195  African clawe...
Feature 1                         
Q13308        207 GQACSSQNFTLSIADE 222  human
XP_001364746  208 GHICSSQNITLSIADE 223  gray short-tailed opossum
NP_001026206  195 GSVCSQDNFTLNIIDE 210  chicken
NP_001093383  196 GSVCSNRNFTLSIIDE 211  African clawed frog

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