1Z7Z,1ZXQ


Conserved Protein Domain Family
IgC2_2_ICAM-1_like

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cd05755: IgC2_2_ICAM-1_like 
Second immunoglobulin (Ig)-like C2-set domain of intercellular cell adhesion molecule 1 (ICAM-1), and similar domains
The members here are composed of the second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule 1 (ICAM-1; also known as domain of cluster of differentiation (CD) 54) and similar proteins. During the inflammation process, these molecules recruit leukocytes onto the vascular endothelium before extravasation to the injured tissues. ICAM-1 may be involved in organ targeted tumor metastasis. The interaction of ICAM-1 with leukocyte function-associated antigen-1 (LFA-1) plays a part in leukocyte-endothelial cell recognition. This group also contains ICAM-2 which also interacts with LFA-1. Transmigration of immature dendritic cells across resting endothelium is dependent on the interaction of ICAM-2 with, yet unidentified, ligand(s) on the dendritic cells. ICAM-1 has five Ig-like domains and ICAM-2 has two. ICAM-1 may also act as host receptor for viruses and parasites. The structures of this group show that the second Ig domain lacks a D strand and thus belonging to the C2-set of the IgSF
Statistics
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PSSM-Id: 409413
View PSSM: cd05755
Aligned: 6 rows
Threshold Bit Score: 170.049
Threshold Setting Gi: 73535843
Created: 17-Aug-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     ########                                                                        
1Z7Z_I     85 TPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREpav-----gepAEVTTTVLVRRDHHGANFSC 159 human
1ZXQ_A     87 PPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYEtfgkaapapqeATATFNSTADREDGHRNFSC 166 human
P13597    111 FPESVELRPLPAWQQVGKDLTLRCHVDGGAPRTQLSAVLLRGEEILSRQpvggh--pkdpKEITFTVLASRGDHGANFSC 188 house mouse
Q00238    112 FPERVELDPLPAWQQVGKNLILRCLVEGGAPRTQLSVVLLRGNETLSRQavd-----gdpKEITFTVLASRGDHGANFSC 186 Norway rat
Q60625    119 RPDRVELVPLPSWQPVGENFTLSCRVPGAGPRASLTLTLLRGGQELIRRsfvgepprargAMLTARVLARREDHRVNFSC 198 house mouse
P13598    111 PPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYEtfgkaapapqeATATFNSTADREDGHRNFSC 190 human
Feature 1                          
1Z7Z_I    160 RTELDLRPQGLELFENTSAPY 180 human
1ZXQ_A    167 LAVLDLMSRGGNIFHKHSAPK 187 human
P13597    189 RTELDLRPQGLALFSNVSEAR 209 house mouse
Q00238    187 FTELDLRPQGLSLFKNVSEVR 207 Norway rat
Q60625    199 LAELDLRPHGLGLFANSSAPR 219 house mouse
P13598    191 LAVLDLMSRGGNIFHKHSAPK 211 human

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