1GL4


Conserved Protein Domain Family
IgI_Perlecan_like

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cd05754: IgI_Perlecan_like 
Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the third immunoglobulin (Ig)-like domain found in Perlecan. Perlecan is a large multi-domain heparin sulfate proteoglycan, important in tissue development and organogenesis. Perlecan can be represented as 5 major portions; its fourth major portion (domain IV) is a tandem repeat of immunoglobulin-like domains (Ig2-Ig15) which can vary in size due to alternative splicing. Perlecan binds many cellular and extracellular ligands. Its domain IV region has many binding sites. Some of these have been mapped at the level of individual Ig-like domains, including a site restricted to the Ig5 domain for heparin/sulfatide, a site restricted to the Ig3 domain for nidogen-1 and nidogen-2, a site restricted to Ig4-5 for fibronectin, and sites restricted to Ig2 and to Ig13-15 for fibulin-2. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.
Statistics
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PSSM-Id: 409412
View PSSM: cd05754
Aligned: 5 rows
Threshold Bit Score: 143.081
Threshold Setting Gi: 30179887
Created: 17-Aug-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1GL4; Mus musculus perlecan Ig3 domain bound to nidogen-1, contacts based on 3.5A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #  #                                     ##  ##
1GL4_B         10 IMVTVeeqrSQSVRPGADVTFICTAKSks--paYTLVWTRlHNGKLPSRAMDFNGILTIRNVQPSDAGTYVCTGSNMFAM 87   house mouse
NP_001001876 1753 ITVTVeekrVQRVKPGADVTFICTAKSks--paYTLVWTRqNHGTLPSRAMDFNGILTIRNVQPEDAGVYVCTGSNMLDM 1830 chicken
CAG03826     2139 IEVTVeapkSQTVRVGSTVSFICTAKSks--paYTLVWTRmGNGKLPNRAMDFNGILTIQNVQPEDAGVYVCTGSNMLAM 2216 Tetraodon nig...
XP_001198206  603 MRVVIndpqTVEVPEGETVQFVCRGISqt--paYTIAWSR-SDGTLPTNARDFMGILTIDTVRLSDAGQYVCMGSNQRDT 679  purple urchin
Q06561         45 VQITVfp-sEKEVRDGRDVSFECRARTsdnsvyPTVRWAR-VGGPLPSSAHDSGGRLTINPVQLSDAGTYICVSDYNGNT 122  nematode
Feature 1                 
1GL4_B         88 DQGTATLH 95   house mouse
NP_001001876 1831 DEGTATLY 1838 chicken
CAG03826     2217 DEGNAVLY 2224 Tetraodon nigroviridis
XP_001198206  680 ADAYATLI 687  purple urchin
Q06561        123 VEARATLS 130  nematode

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