1F6A,1E4K,2FCB,3D5O


Conserved Protein Domain Family
Ig1_FcgammaR_like

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cd05752: Ig1_FcgammaR_like 
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.
Statistics
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PSSM-Id: 409410
View PSSM: cd05752
Aligned: 17 rows
Threshold Bit Score: 117.463
Threshold Setting Gi: 123228105
Created: 20-Sep-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:pentraxin binding site [polypeptide binding site]
Evidence:
  • Structure:3D5O; human FcgammaRIIa first Ig domain interacts with serum amyloid P component (SAP), forming contacts with three chains of the SAP pentamer. Site defined using 4.0 A contacts.
    View structure with Cn3D
  • Comment:Pentraxins, including SAP, are ancient conserved mediators of innate immunity that have been determined to interact with FcgammaRs to activate leukocyte-mediated phagocytosis.
  • Comment:Note that the pentameric SAP forms contacts with different but overlapping sets of residues in the first and second Ig domains of FcgammaRIIa. The first Ig domain forms contacts with three of the five SAP chains, while the second Ig domain forms contacts with two SAP chains.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ##                 #           ####                                          
1F6A_A         5 PKVSLNPPWNRIFKGENVTLTCNgnnf----fevSSTKWFHNGSLSee-tnSSLNIVnakfeDSGEYKCQHQqv---aES 76  human
1E4K_C         9 AVVFLEPQWYSVLEKDSVTLKCQgays----pedNSTQWFHNESLIss-qaSSYFIDaatvnDSGEYRCQTNls---tLS 80  human
3D5O_F         5 AVLKLEPPWINVLQEDSVTLTCQgars----pesDSIQWFHNGNLIpthtqPSYRFKan-nnDSGEYTCQTGqt---sLS 76  human
NP_036856     28 SVVSLDPPWIRILTGDKVTLICNgnns----sqmNSTKWIHNDSISnv-ksSHWVIVsatiqDSGKYICQKQgf---yKS 99  Norway rat
P79107        26 AVVLLDPQWNHVLTNDRVTLKCQgdyp----vedNSTKWWHNGTLIss-qtPSYFIAdvkvqDSGEYKCQTGls---aPS 97  cattle
NP_776742     26 AVVLLDPQWNHVLTNDRVTLKCQgdyp----vedNSTKWWHNGTLIssqtpSYFHIPeakleHSGSYFCRGIigskneSS 101 cattle
XP_001116885  25 AVLLLDPPWSTAFKGEKVTLTCRgisq---sparGDTFWYRDEKLWki-qhNAIQIR-----GSGNYQCKTQgs---sLS 92  rhesus monkey
XP_001168141  23 PVISVHPPWTTFFKGERVTLTCNgfqf----yatEKTTWYHGHYWGekltlTAGNTLev--rESGLYRCQARgs---pRS 93  chimpanzee
CAM20342      16 PILSLHPPWTTIFKGERVTLKCDgyhplllelqpISTLWYLGHLLLps-hkKSIEVQ-----TPGVYRCQTRga---pVS 86  human
XP_001380075 111 AIVHLSPPWTTIFQGEKVTLTCDgfn-----ssiPRTWWYKNEQRQkt--rSTKSIVi---qQPGMYRCQNQds---tLS 177 gray short-tail...
Feature 1               
1F6A_A        77 EPVYLEV 83  human
1E4K_C        81 DPVQLEV 87  human
3D5O_F        77 DPVHLTV 83  human
NP_036856    100 KPVYLNV 106 Norway rat
P79107        98 DPVKLEV 104 cattle
NP_776742    102 ESVQITV 108 cattle
XP_001116885  93 DAVHVEF 99  rhesus monkey
XP_001168141  94 NPVRLLF 100 chimpanzee
CAM20342      87 DPIHLSV 93  human
XP_001380075 178 DPVHLVV 184 gray short-tailed opossum

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