Conserved Protein Domain Family
Ig_Pro_neuregulin

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cd05750: Ig_Pro_neuregulin 
Immunoglobulin (Ig)-like domain in neuregulins
The members here are composed of the immunoglobulin (Ig)-like domain in neuregulins (NRGs). NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. There are four members of the neuregulin gene family (NRG-1, NRG-2, NRG-3, and NRG-4). The NRG-1 protein, binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. The other NRGs proteins bind one or the other or both of these ErbBs. NRG-1 has multiple functions: in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors, while in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. Less is known of the functions of the other NRGs. NRG-2 and NRG-3 are expressed predominantly in the nervous system. NRG-2 is expressed by motor neurons and terminal Schwann cells, and is concentrated near synaptic sites and may be a signal that regulates synaptic differentiation. NRG-4 has been shown to direct pancreatic islet cell development towards the delta-cell lineage.
Statistics
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PSSM-Id: 409408
View PSSM: cd05750
Aligned: 6 rows
Threshold Bit Score: 148.814
Threshold Setting Gi: 528513898
Created: 11-Jul-2007
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:putative Ig strand A [structural motif]
Evidence:
  • Comment:based on sequence similarity to other known I-set Ig superfamily domains.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #######                                                                         
O14511       237 PKLKKMKsqt-gqvGEKQSLKCEAaagnPQPSYRWFKDGKELNRs-----rDIRIKYGNg-rKNSRLQFNKVKVEDAGEY 309 human
O93383        37 PKLKEIKtqs-vqeGKKLVLKCQAvseqPSLKFRWFKGEKEIGAknkpdskPEHIKIRGk-kKSSELQISKASSADNGEY 114 African clawed ...
Q02297        37 PRLKEMKsqe-saaGSKLVLRCETsseySSLRFKWFKNGNELNRkn----kPQNIKIQKk-pGKSELRINKASLADSGEY 110 human
Q05199        29 PKLKEMKnqe-vavGQKLVLRCETtseyPALRFKWLKNGKEITKkn----rPENVKIPKkqkKYSELHIYRATLADAGEY 103 chicken
CAG00535      33 PKLKPMLiptrveeGNKLIVKCEAtg-nPLPTYRWFKDGNELKK-------SKKVRIRNs-qKNSRVQINKARVEDSGNY 103 Tetraodon nigro...
XP_005161384 141 PSLRRMKnpvladeGSRLIVKCEAtg-sPAPEYKWYKDGAELKR-------SKEIKIRNn-kKNSKVQIGSAKLEDSGNY 211 Danio rerio
Feature 1                           
O14511       310 VCEAENILGKDTVRGRLYV 328 human
O93383       115 KCMVSNQLGNDTVTVNVTI 133 African clawed frog
Q02297       111 MCKVISKLGNDSASANITI 129 human
Q05199       104 ACRVSSKLGNDSTKASVII 122 chicken
CAG00535     104 TCVVENLLGKDNSTGTVQV 122 Tetraodon nigroviridis
XP_005161384 212 TCVAENILGKANGTSTVHV 230 Danio rerio

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