Conserved Protein Domain Family
Ig_Perlecan_like

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cd05743: Ig_Perlecan_like 
Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
The members here are composed of the immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar proteins. Perlecan consists of five domains: domain I has three putative heparan sulfate attachment sites, domain II has four LDL receptor-like repeats, and one Ig-like repeat, domain III resembles the short arm of laminin chains, domain IV has multiple Ig-like repeats (21 repeats in human perlecan), and domain V resembles the globular G domain of the laminin A chain and internal repeats of EGF. Perlecan may participate in a variety of biological functions including cell binding, LDL-metabolism, basement membrane assembly and selective permeability, calcium binding, and growth- and neurite-promoting activities.
Statistics
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PSSM-Id: 143220
View PSSM: cd05743
Aligned: 6 rows
Threshold Bit Score: 138.392
Threshold Setting Gi: 115692230
Created: 17-Aug-2007
Updated: 17-Aug-2020
Structure
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Aligned Rows:
 
Feature 1:Ig strand B [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #######                                                                    
P98160        421 GQTVTFTCVAIGVPTPIINWRLNWGhipshprvtvtseGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLEL 498  human
CAG03826      325 GSTVTFTCQAVGVPMPIITWRLNWGhipasarismmseNGRGTLTIRDVKESDQGAYTCEAINAKGLVFGIPDGVLTL 402  Tetraodon nigro...
NP_001001876  409 GQTVSFTCVATGVPTPIITWRLNWGsipssrrvsivseGGQGTLTIRDVKESDQGAYTCEAINTRGMVFGIPDSILTV 486  chicken
NP_001027038 1752 YEVLELTCVATGTPTPTIVWRLNWGhvpdkc--esksyGGTGTLRCPDMRPQDSGAYSCEIINTRGTHFVNPDTIVTV 1827 fruit fly
Q06561        286 GTTFSLTCKAVAVPEPYINWRLNWGpvcepprclqtseGGYGTLTIHDAQPVDQGAYTCEAINVKGRVLATPDCIVRV 363  nematode
XP_798237     296 GERVEIICEAQGIPTPIISWRLNWGpvpdra--iitnsNGYGTLVLENVRESDQGAYTCEAMNNQGYILAQPDAILTV 371  purple urchin

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