1E07,1E07,1E07,1L6Z


Conserved Protein Domain Family
IgI_hCEACAM_2_4_6_like
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cd05740: IgI_hCEACAM_2_4_6_like 
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.
Links
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Statistics
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PSSM-Id: 409402
Aligned: 18 rows
Threshold Bit Score: 116.34
Created: 10-Aug-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #####                                                                           
1E07_A       112 KPSISsnNSKPVEd-kDAVAFTCEPEtq--daTYLWWVNNQSLPvsPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVS 188 human
1L6Z_A       112 QPFLQv-TNTTVKe-lDSVTLTCLSNdi--gaNIQWLFNSQSLQltERMTLSQNNSILRIDPIKREDAGEYQCEISNPVS 187 house mouse
P31809       146 KPNITsnNSNPVEg-dDSVSLTCDSYtdpdniNYLWSRNGESLSegDRLKLSEGNRTLTLLNVTRNDTGPYVCETRNPVS 224 house mouse
P16573       146 KPNVTgnNSNPMEg-ePFVSLMCEPYtn--ntSYLWSRNGESLSegDRVTFSEGNRTLTLLNVRRTDKGYYECEARNPAT 222 Norway rat
Q00887       148 KPYISssNLNPREa-mEAVRLICDPEtl--daSYLWWMNGQSLPvtHRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVS 224 human
Q63111       620 QPFIRv-TESSVRv-kSSVVLTCLSAdt--gtSIQWLFNNQNLRltQRMSLSQTKCQLSIDPVRREDAGEYRCEVSNPVS 695 Norway rat
AAH24164     175 KPSISsnNSNPVEd-kDAVAFTCEPEtq--dtTYLWWINNQSLPvsPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVS 251 Homo sapiens
NP_001034302 191 QPTVLa-NSTALVerrDTLRLMCSSPsp--taEVRWFFNGGALPvaLRLGLSPDGRVLARHGIRREEAGAYQCEVWNPVS 267 human
NP_031702    297 QPFMRv-TDSTVRv-qSSVVFTCFSDnt--gvSIHWLFNNQSLQltERITLSPSKCQLRINPVRKEDGGEYQCEVFNLAS 372 Mus musculus
AAI58512     144 ASGIStdNKEPQEn--QPVTLTCSANna---eQILWGKNGVPLP--PGLSLSADNRTLTFPRISRSDTGQYRCEASNAVS 216 western clawed ...

Feature 1                    
1E07_A       189 ARRSDSVILNVL 200 human
1L6Z_A       188 VRRSNSIKLDII 199 house mouse
P31809       225 VNRSDPFSLNII 236 house mouse
P16573       223 FNRSDPFNLDVI 234 Norway rat
Q00887       225 ASRSDPVTLNLL 236 human
Q63111       696 SKTSLPVSLDVI 707 Norway rat
AAH24164     252 ANRSDPVTLNVT 263 Homo sapiens
NP_001034302 268 VSRSEPINLTVY 279 human
NP_031702    373 SKSSLPVSLAVM 384 Mus musculus
AAI58512     217 KIISDPYTLTVN 228 western clawed frog

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