Conserved Protein Domain Family
IgI_3_RPTP_IIa_LAR_like

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cd05739: IgI_3_RPTP_IIa_LAR_like 
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
The members here are composed of the third immunoglobulin (Ig)-like domain found in the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR. LAR belongs to the RPTP type IIa subfamily. Members of this subfamily are cell adhesion molecule-like proteins involved in central nervous system (CNS) development. They have large extracellular portions comprised of multiple Ig-like domains and two to nine fibronectin type III (FNIII) domains and a cytoplasmic portion having two tandem phosphatase domains. Included in this group is Drosophila LAR (DLAR).
Statistics
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PSSM-Id: 409401
View PSSM: cd05739
Aligned: 6 rows
Threshold Bit Score: 145.428
Threshold Setting Gi: 115670863
Created: 7-Aug-2007
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ###                                                                             
NP_001077045  236 SIPp-tNHEVMPGGSVNLTCVAVGAPMPYVKWMTGEVELTKDEEMPVGRNVLELTNIRQSTNYTCVAISSLGMIEATAQV 314  zebrafish
AAA28668      237 SRPpetISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVV 316  fruit fly
ABN41557      153 SIPp-sNHEVMPGGSVNLTCVAVGAPMPYVKWMAGVEELTKEDEMPVGRNVLELNNIMQSADYTCVAISSLGMIEATAQI 231  chicken
XP_785900     105 TILp-eNQEVVPGGSVNLTCAAYGSPMPRVRWMKAGMDLDDMDDLPIGRNVLQLRDIYESANYTCVATSLLGTIDTSARV 183  purple urchin
NP_001081987  232 SIPp-sNHEVMPGGSVNLTCVAVGAPMPYVKWMAGLEELTKEDEMPVGRNGLELTNIKDSANYTCVAISSLGMIEAVAQI 310  African clawe...
P10586        235 SIPp-sSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQV 313  human
Feature 1            
NP_001077045  315 SVK 317  zebrafish
AAA28668      317 KVQ 319  fruit fly
ABN41557      232 TIK 234  chicken
XP_785900     184 TVR 186  purple urchin
NP_001081987  311 TVK 313  African clawed frog
P10586        314 TVK 316  human

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