Conserved Protein Domain Family
Ig_DSCAM

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cd05735: Ig_DSCAM 
Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
The members here are composed of the immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM). DSCAM is a cell adhesion molecule expressed largely in the developing nervous system. The gene encoding DSCAM is located at human chromosome 21q22, the locus associated with the intellectual disability phenotype of Down Syndrome. DSCAM is predicted to be the largest member of the IG superfamily. It has been demonstrated that DSCAM can mediate cation-independent homophilic intercellular adhesion.
Statistics
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PSSM-Id: 409398
View PSSM: cd05735
Aligned: 17 rows
Threshold Bit Score: 205.801
Threshold Setting Gi: 642061941
Created: 31-Aug-2007
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:putative Ig strand A [structural motif]
Evidence:
  • Comment:based on sequence similarity to the structure of Drosophila melanogaster DSCAM

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ####                                                                            
O60469        785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIInp------emARYLVSTKEVGEEVISTLQILPtVRE 858  human
XP_028838517  786 KIPAMITSYPNTTYAIKGEKKEMSCTAHGEKPIMVRWEKEAHIInp------etNRYVVTVKEEGDEVASTLQISPtVRE 859  denticle herring
XP_007904921  207 KIPAMITSYPNTTLATQGQRKEVSCTAHGEKPIIVRWEKEDTVIdpq-----rmFRYIVSTKEMGDEVVSTLQITPtVRG 281  elephant shark
XP_007906987  785 KIPAMITSHPNTTIAIKGQNKELNCTARGERPIIIRWEKEDTVIdpd-----rmFRYTVGTKDNGEEVVSTLRIVPaDRG 859  elephant shark
NP_001354833  786 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIdpd-----rvMRYAIATKDNGDEVVSTLKLKPaDRG 860  human
E1C8P7        787 KIPAMITSHPNTTIAIKGQSKELNCTARGERPIIIRWEKGDTVIdpd-----rnMRYAIATKDNGDEVISTLKLKPaDRG 861  chicken
OCA29250      282 KIPAMITSHPNTTIAIKGQTKGLNCTARGERPIIIRWEKGDTVIdpd-----rnLRYLIATKDSGDEVISTLTLKPaERG 356  tropical claw...
NP_001025395  787 KIPAMITSYPNNSLATKGEKIEMSCKAHGEKPIMVRWEKEVEKEkqshminpdmWRHTVTVKNVGDEVVSTLQIYPtMRE 866  zebrafish
XP_012693760  832 KIPAMITSYPNTTLATKGKKKEMSCTAKGEKPIMIRWEKEKEIInp------emSRYVVTVREVGDEVNSTLQVLP-VRG 904  Atlantic herring
XP_026871258  786 KIPAMITSYPNSTVATKGEEIQMSCRAHGEKPIMMRWEKEVEKEkqshminpdmWRHTVSNSKGPDDVISTLKIQPtMRE 865  electric eel
Feature 1                                   
O60469        859 DSGFFSCHAINSYGEDRGIIQLTVQE 884  human
XP_028838517  860 DSGFFSCHAINSYGEDRGLIQLIVRE 885  denticle herring
XP_007904921  282 DSGFFSCHAINSYGEDRGLIQLTVQE 307  elephant shark
XP_007906987  860 DSGFFSCHAINSYGEDRGLIQLTVQE 885  elephant shark
NP_001354833  861 DSVFFSCHAINSYGEDRGLIQLTVQE 886  human
E1C8P7        862 DSVFFSCHAINSYGEDRGLIQLTVQE 887  chicken
OCA29250      357 DSVFFSCHAINSYGEDRGLIQLTVQE 382  tropical clawed frog
NP_001025395  867 DSGFFSCHAINSYGEDRGILQLTVQE 892  zebrafish
XP_012693760  905 DSGFFSCHAINSYGEDKGIIQLTVEE 930  Atlantic herring
XP_026871258  866 DSGFFSCHAINSYGEDRGIIQLTVQE 891  electric eel

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