Conserved Protein Domain Family
Ig_DSCAM

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cd05734: Ig_DSCAM 
Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
The members here are composed of the immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM). DSCAM is a cell adhesion molecule expressed largely in the developing nervous system. The gene encoding DSCAM is located at human chromosome 21q22, the locus associated with the intellectual disability phenotype of Down Syndrome. DSCAM is predicted to be the largest member of the IG superfamily. It has been demonstrated that DSCAM can mediate cation-independent homophilic intercellular adhesion.
Statistics
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PSSM-Id: 409397
View PSSM: cd05734
Aligned: 15 rows
Threshold Bit Score: 153.802
Threshold Setting Gi: 47213409
Created: 27-Jun-2007
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:putative Ig strand A [structural motif]
Evidence:
  • Comment:based on sequence similarity to the structure of Drosophila melanogaster DSCAM

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #####                                                                           
Q8TD84        689 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHpvp-ltGRIQILPNSSLLIRHVLEEDiGYYLC 767  human
XP_005988243  616 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHpvp-ltGRIQILSNGSLLVRHVLEEDiGYYLC 694  coelacanth
CDQ97143      179 PPQFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGTGNPQQYHpvp-ltGRIQIMGNGSLLIRHVLEEDrGYYLC 257  rainbow trout
XP_014342014  683 PPRFVVQPSDQDGIYGKAVILNCSAEGYPVPTIVWKYSKGAGVPQFQPia--lnGRIQLLTNGSLLIKHVLEEDsGYYLC 760  coelacanth
OCT93751      584 PPRFVVQPTDQDGIYGKAVILNCSAEGYPVPNIVWKYSKGAGVPQFQPia--lnGRIQLLTNGSLLIKHILEEDsGYYLC 661  African clawe...
EAX09621      427 PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPia--lnGRIQVLSNGSLLIKHVVEEDsGYYLC 504  human
XP_028664324  688 PPRFVVQPNNQDGIYGKSGVLNCSVDGYPPPKVMWKHSKASGNSQKYHpvt-lnGRIQILANGSLLIRHVLEEDvGNYLC 766  reedfish
XP_007904921  111 PPHFVVQPSDQDGIYGKSVILNCSAEGYPVPTIVWKYSKGAGVPQFQSit--lnGRVRLLVNGSLLIKHVLEEDsGYYLC 188  elephant shark
XP_028656020  689 PPRFVVQPGDQDGIYGKAVVLNCSAEGYPVPTIVWNFSKGPDVPIFQPia--lnGRIQLLINGSLLIKHVLEEDsGYYLC 766  reedfish
NP_001025395  689 PPRFKVQPQDQDGIYGKSVILNCSADGEPRPTIEWKYSKGAGVPQFQPialnsgFRVQLLGNGSLLIKHVLEEDaGYYLC 768  zebrafish
Feature 1                           
Q8TD84        768 QASNGVGTDISKSMFLTV 785  human
XP_005988243  695 QASNGVGTDISKSMFLTV 712  coelacanth
CDQ97143      258 QASNGVGSDISKSMVLTV 275  rainbow trout
XP_014342014  761 KVSNDVGADVSKSMYLTV 778  coelacanth
OCT93751      662 KVSNDVGADVSKSMYLTV 679  African clawed frog
EAX09621      505 KVSNDVGADVSKSMYLTV 522  human
XP_028664324  767 QASNGVGTDISKSLYLTV 784  reedfish
XP_007904921  189 QVSNDVGADVSKSMYLTV 206  elephant shark
XP_028656020  767 KVSNDVGADVSKSLYFTV 784  reedfish
NP_001025395  769 KVSNDVGADVSKSMYLNV 786  zebrafish

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