2VA4


Conserved Protein Domain Family
IgI_NCAM-1_like

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cd05732: IgI_NCAM-1_like 
Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1) and similar proteins
The members here are composed of the fourth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. Also included in this group is NCAM-2 (also known as OCAM/mamFas II and RNCAM) NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE). One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.
Statistics
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PSSM-Id: 409395
View PSSM: cd05732
Aligned: 7 rows
Threshold Bit Score: 171.939
Threshold Setting Gi: 18859063
Created: 17-Aug-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      ######                                                                          
2VA4_A      94 VQPHIIQLKNETTYEn-gQVTLVCDAEGEPIPEITWKRAVDGFTFtegdksldgRIEVKGQHGSSSLHIKDVKLSDSGRY 172  human
P13590     306 AKPKITYVENKTAMEledQITLTCEASGDPIPSITWKTSTRNISNeekt--ldgRIVVRSHARVSSLTLKEIQYTDAGEY 383  chicken
EAW67201   306 AKPKITYVENQTAMEleeQVTLTCEASGDPIPSITWRTSTRNISSeekt--ldgHMVVRSHARVSSLTLKSIQYTDAGEY 383  human
CAM60097   298 VQPHITKLRNVTAVEg-sAAMISCKAEGEPLPEISWRRASDGHSFsdgdkspdgRVEVRGRYGESMLTIVVVKLSDWGRF 376  zebrafish
XP_425540  315 VQPQIIQLKNETTFEn-gKATLICEAEGEPIPEITWKRATDGITFsegdkspdgRIEVKGQHGKSSLHIKDVKLSDSGRY 393  chicken
127855     301 AKPKITYVENKTAVEl-dEITLTCEASGDPIPSITWRTAVRNISSeatt--ldgHIVVKEHIRMSALTLKDIQYTDAGEY 377  African clawed frog
NP_571277  300 VQPKITFLENQTASEleeQITLTCEATGDPTPNIIWSFGRRVFTEneqs--ldgNVVVRSDARVSSLTLKYVQFTDAGQY 377  zebrafish
Feature 1                         
2VA4_A     173 DCEAASRIGGHQKSMYLDI 191  human
P13590     384 VCTASNTIGQDSQAMYLEV 402  chicken
EAW67201   384 ICTASNTIGQDSQSMYLEV 402  human
CAM60097   377 DCEALSRIGGHQKSMFLDI 395  zebrafish
XP_425540  394 DCEAASRIGGHQKSMYLDI 412  chicken
127855     378 FCIASNPIGVDMQAMYFEV 396  African clawed frog
NP_571277  378 LCTARNSIGQDIQSMYLEV 396  zebrafish

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