1QZ1,1IE5


Conserved Protein Domain Family
IgI_3_NCAM-1

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cd05730: IgI_3_NCAM-1 
Click on image for an interactive view with Cn3D
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
The members here are composed of the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.
Statistics
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PSSM-Id: 143207
View PSSM: cd05730
Aligned: 4 rows
Threshold Bit Score: 175.891
Threshold Setting Gi: 134085230
Created: 11-Jul-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig3-Ig interaction interface [polypeptide binding site]
Evidence:
  • Comment:Based on crystallographic data and biological experiments.
  • Comment:Ig3 has been proposed to participate in interactions between NCAM molecules on the surface of opposing cells, through binding to the Ig1 and Ig2 modules.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #                ## #                          #  #       #          
1QZ1_A     194 PPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIEneeeddeKHIFSDDSSELTIRNVDKNDEAEYVCIA 273  Norway rat
1IE5_A      11 PPSVRARQSTMNATANLSQSVTLACDADGFPEPTMTWTKDGEPIEqed-neeKYSFNYDGSELIIKKVDKSDEAEYICIA 89   chicken
547997     208 PPLIQARQIRVNATANMDESVVLSCDADGFPDPEISWLKKGEPIEdg---eeKISFNEDKSEMTIYRVEKEDEAEYSCIA 284  African clawed frog
CAM60095   208 LPTIRIRQAETNATADTGFSTLLACDPDGFPEPIVTWRRNNAPLEsg----nKYSFNEDGSEMTVLDVTKLDEGDYTCIA 283  zebrafish
Feature 1                   # ## 
1QZ1_A     274 ENKAGEQDASIHLKVFAK 291  Norway rat
1IE5_A      90 ENKAGEQDATIHLKVFAK 107  chicken
547997     285 NNQAGEAEAIVLLKVYAK 302  African clawed frog
CAM60095   284 KNKAGESEQELSLKVFVQ 301  zebrafish

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