3LAF


Conserved Protein Domain Family
IgI_1_Neogenin_like

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cd05722: IgI_1_Neogenin_like 
First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the first immunoglobulin (Ig)-like domain in neogenin and related proteins. Neogenin is a cell surface protein which is expressed in the developing nervous system of vertebrate embryos in the growing nerve cells. It is also expressed in other embryonic tissues and may play a general role in developmental processes such as cell migration, cell-cell recognition, and tissue growth regulation. Included in this group is the tumor suppressor protein DCC which is deleted in colorectal carcinoma. DCC and neogenin each have four Ig-like domains followed by six fibronectin type III domains, a transmembrane domain, and an intracellular domain. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.
Statistics
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PSSM-Id: 409387
View PSSM: cd05722
Aligned: 8 rows
Threshold Bit Score: 154.173
Threshold Setting Gi: 148277558
Created: 27-Sep-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ####                                                                            
3LAF_A         21 SLHFVSEPSDAVTMRGGNVLLNCSAESdrgvPVIKWKKDGLILALgmddRKQQLPNGSLLIQNILHSRh-HKPDEGLYQC 99   Norway rat
NP_001091714   28 ELSFTLEPSDIIAVQQQPLMLHCQVEGip-pISTQWRRSGALVQEd--hNYVMFTNGSLLITHFQKIKtdGSSDEGDYEC 104  zebrafish
AAH92691       33 PFWFSTEPSDTLAVRGAPVLLNCSVHSes-pAKIEWKKDGSFLSLasdeRRQVLADGSLLISSVVHSKh-NKPDEGVYQC 110  zebrafish
NP_001079254   39 SLWFLSEPSDAVTMRGGNVVLNCSAQSdrgaPIIKWKKDGVYLNLvideRRQQLPSGSFLIQNVVHSRh-HRPDEGVYQC 117  African clawe...
Q90610         18 PFYFLVEPMDILSVRGASVIMNCSSYCet-pPKIEWKKDGTLLNLvsddRRQLLPDGSLLINSVVHSKh-NKPDEGYYQC 95   chicken
P43146         39 ALRFLSEPSDAVTMRGGNVLLDCSAESdrgvPVIKWKKDGIHLALgmdeRKQQLSNGSLLIQNILHSRh-HKPDEGLYQC 117  human
ABG81423       46 PFYFLTEPVDTVTLRGFAAVLNCSAYAdp-tPKIEWKKDGTFLNLvsddRRRLLPDGSLLITSVVHSKh-NKPDEGFYQC 123  Kenyan clawed...
NP_001038495   26 ELFFIKEPHDVTAMRRDAVVLDCQAHGea-pIGIRWLKNGVTITEs--eRVYSLSNGSLLISEVESRK--DKSDEGFYQC 100  zebrafish
Feature 1                            
3LAF_A        100 EASLgdsGSIISRTAKVMV 118  Norway rat
NP_001091714  105 IAQNf-fGLVVSRKARVQA 122  zebrafish
AAH92691      111 VATIdnlGTIISRTARLNV 129  zebrafish
NP_001079254  118 EASLdsvGTIVSRTAKVLV 136  African clawed frog
Q90610         96 VATVeslGSIVSRTAKLTV 114  chicken
P43146        118 EASLgdsGSIISRTAKVAV 136  human
ABG81423      124 VATVeslGSIVSRTARLSV 142  Kenyan clawed frog
NP_001038495  101 LAQNk-yGSILSQRARLTI 118  zebrafish

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