1XED,2Q87,2OCW,2NMS,2FRG,1SMO,1Q8M,1HKF,1ZOX,2OCW,2OCW,2OCW


Conserved Protein Domain Family
IgV_pIgR_like

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cd05716: IgV_pIgR_like 
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins
The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.
Statistics
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PSSM-Id: 409381
View PSSM: cd05716
Aligned: 37 rows
Threshold Bit Score: 78.9795
Threshold Setting Gi: 189515365
Created: 16-Aug-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:CDR1-dIgA binding residues [polypeptide binding site]
Evidence:
  • Comment:Identified via mutation studies of the CDR1 region. Point mutations of these residues and others in the neighboring non-conserved CDR1 reduce or abolish binding to dIgA.
  • Comment:In addition to CDR1, the other two CDR loops appear to be involved in the interaction with antibody.
  • Citation:PMID 7989333

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   ###                                                
1XED_A       4 IFGpeEVNSVEGNSVSITCYypptsvnrhTRKYWCRqgarggCITLISse------gYVSskyagRANLTNFpe-nGTFV 76   human
2OCW_A     446 LKVpgNVTAVLGETLKVPCHfpck--fssYEKYWCKwnn-tgCQALPSq--------DEG-----PSKAFVNcdenSRLV 509  human
P01832     460 SPTidKFTAVQGEPVEITCHfpck--yfsSEKYWCKwnd-hgCEDLPTk-------lSSS-----GDLVKCNn--nLVLT 522  rabbit
AAQ14493   360 LTGkeEVQAEVGSRVDLTCSypck--yysYEKYWCKwsr-dgCTPLTSsd------qSHP-----GLDVSCDta-nKTLI 424  chicken
CAH19212    16 VVAhtLISGHRGERLDIRCPyksg--yesNPKYFCKg----kCNYGYKnivvksgspAKDe----RFSLTDDkr-sRVFT 84   common carp
XP_695421  369 SVImsPVVRREGESAQIFCPydsi--yqsKSKSLCKg----kCSTRDTrpld--etvREEk---eRLTLHEDvt-aSVFT 436  zebrafish
CAH91352   464 LKVpgNVTAVLGQTLKVPCHfpck--fssYEKYWCKwnn-tgCQALPSq--------DKGp---sKASVNCDen-sRLVS 528  Pongo abelii
XP_695421  106 NPKvmTESVHLGGEVKISCQip-----eeQKVLFCKeeynqsCQKTRAs-------eDPQl----TRAGSVGge-eRVFT 168  zebrafish
CAF89861   155 RCQtqAQTVKTAAGETVPCDpprw--gamSELFFCKens-ntCAEMLStr------sSERt----IGSFTLKet-dGNFS 220  Tetraodon nigrov...
ABK62772   360 KEVvaSTGKQVIIPCTYPCRyt------sYQKYWCKwgn-ygCNPMISq--------DND-----EDGLSINce-nREVV 418  African clawed frog
Feature 1                                            
1XED_A      77 VNIAQl-sQDDSGRYKCGLGins-----rgLSFDVSLE 108  human
2OCW_A     510 SLTLNlvtRADEGWYWCGVKqgh-----fyGETAAVYV 542  human
P01832     523 LTLDSv-sEDDEGWYWCGAKdgh----efeEVAAVRVE 555  rabbit
AAQ14493   425 LSLDPv-tVEDQGWYWCGVKhng----hygETMAVSLQ 457  chicken
CAH19212    85 ISITDl-rTEDEGQYWCVVKktlft-tdvyTEILLLVK 120  common carp
XP_695421  437 GTITGl-tAEDAGKYWCAVTldrel-nylyTHLMVIIK 472  zebrafish
CAH91352   529 LTLNPv-tRADEGWYWCGVKq---------GHFYGETA 556  Pongo abelii
XP_695421  169 VSISNv-sVRDAGVYWCGAEtrdthltfisLTTKIQLS 205  zebrafish
CAF89861   221 IFISQa-sSRDNGVYWCASKtely--raglQKITIKVK 255  Tetraodon nigroviridis
ABK62772   419 LTINTv-kKTDEGWYWCGVTkfg----rygETLAVHLK 451  African clawed frog

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