2DF3,2ZG2,1URL,5IHB


Conserved Protein Domain Family
IgV_CD33

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cd05712: IgV_CD33 
Click on image for an interactive view with Cn3D
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.
Statistics
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PSSM-Id: 409377
View PSSM: cd05712
Aligned: 9 rows
Threshold Bit Score: 166.411
Threshold Setting Gi: 56554238
Created: 17-Sep-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2DF3_A         9 YSLTMQSSVTVQEGMCVHVRCSFSYPvdsqtdsdPVHGYWFRAGndiswkaPVATNNPAWAVQEETRDRFHLLGDPQTKN 88  human
EAW52587      22 YSLQVQRQVPVPEGLCVIVSCNLSYPrdgwdestAAYGYWFKGRtspktgaPVATNNQSREVEMSTRDRFQLTGDPGKGS 101 human
2ZG2_A         3 YELQVQKSVTVQEGLCVLVPCSFSYPwrswysspPLYVYWFRDGeipyyaeVVATNNPDRRVKPETQGRFRLLGDVQKKN 82  human
1URL_A         2 WGVSSPKNVQGLSGSCLLIPCIFSYPadvp-vsnGITAIWYYDYsgk--rqVVIHSGDPKLVDKRFRGRAELMGNMDHKV 78  house mouse
5IHB_A         4 FWLQVQESVTVQEGLCVLVPCTFFHPipyydknsPVHGYWFREGaiisgdsPVATNKLDQEVQEETQGRFRLLGDPSRNN 83  human
AAH29896      21 YELQVQKSVTVQEGLCVLVPCSFSYPwrswysspPLYVYWFRDGeipyyaeVVATNNPDRRVKPETQGRFRLLGDVQKKN 100 human
NP_001088138  18 FKIEAPVNVIVQRGLCVLIPCNFTVGpkyn-ltkDAIGIWYKGHpn----dPVAASTNSSQFPDTTNGRFIFTGKVSAGD 92  African clawed ...
AAI22605      22 WGAWMPSSISAFEGTCVSIPCRFSFPdel--rpaVVHGVWYFNSpypknypPVVFKSRTQVVHESFQGRSRLLGDLGLRN 99  cattle
CAF33196      22 WNVWMPRDISAMTNSCVVIPCSFTYPsgir-pyrGVHGIWYFGHpypqlfpPVVLKSRTDIVHESYKGRTKLLGDLTQKN 100 zebrafish
Feature 1                          #        ##           
2DF3_A        89 CTLSIRDARMSDAGRYFFRMEKg-nIKWNYkydQLSVNVT 127 human
EAW52587     102 CSLVIRDAQREDEAWYFFRVERgsrVRHSFlsnAFFLKVT 141 human
2ZG2_A        83 CSLSIGDARMEDTGSYFFRVERgrdVKYSYqqnKLNLEVT 122 human
1URL_A        79 CNLLLKDLKPEDSGTYNFRFEIsdsNRWLDv-kGTTVTVT 117 house mouse
5IHB_A        84 CSLSIVDARRRDNGSYFFRMERg-sTKYSYkspQLSVHVT 122 human
AAH29896     101 CSLSIGDARMEDTGSYFFRVERgrdVKYSYqqnKLNLEVT 140 human
NP_001088138  93 CSFSISDAQPGDAAKYRFRLEDrdpLKFNYlhiQPSVSVT 132 African clawed frog
AAI22605     100 CTLLLSNLSPELGGKYYFRGDLggyNQYTFs-eHSVLDII 138 cattle
CAF33196     101 CTLLISNIGVEHSGKYYFRADLggaNIYTFp-dFTKLQVL 139 zebrafish

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