Conserved Protein Domain Family
M20_ArgE_RocB

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cd05654: M20_ArgE_RocB 
M20 Peptidase arginine utilization protein, RocB
Peptidase M20 family, ArgE RocB (arginine utilization protein, RocB; arginine degradation protein, RocB) subfamily. This group of proteins is possibly related to acetylornithine deacetylase (ArgE) and may be involved in the arginine and/or ornithine degradation pathway. In Bacillus subtilis, RocB is one of the three genes found in the rocABC operon, which is sigma L dependent and induced by arginine. The function of members of this family is as yet unknown, although they are predicted as deacetylases.
Statistics
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PSSM-Id: 349905
Aligned: 9 rows
Threshold Bit Score: 745.319
Created: 15-Aug-2007
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
metal bindingputative dimer
Feature 1: metal binding site [ion binding site], 6 residue positions
Conserved feature residue pattern:H D E E [ED] HClick to see conserved feature residue pattern help
Evidence:
  • Comment:annotation is based on similarity to other subgroups

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P39635        13 ERVEALTASLVSLSSVNGTvGEGTKADFIKEVITSYPYFQENPSHvweqaIPNDPYKRKNIFAFIKGhg-eSRNTVIYHA 91  Bacillus subtilis
NP_347007      6 EEIENLTVELVKVPSVNGTeGEGNIGNKILSYLKEIDYFKEHEEYafripLKNDKLGRGNVFALIRGekgqSNRTIILHG 85  Clostridium ace...
YP_001255403   5 DKIFKTLDRLVKIPSISGTeKENLAVDEIYNILMDIDYFKNNKSNvkvhnIEGDMHNRCFLTALLEGkk-pSKDIIILTG 83  Clostridium bot...
NP_832724      8 EQLVQLLSSLVEIPSITGSeAEVILPDFVVEQLSDLQYFKQNPHHl---qKNPTGDGRYFVTALVKKsd-sTKNTVILVS 83  Bacillus cereus...
NP_437944     19 ERVRQFALRMTSWPSETGTpGEASFADRLHGLLGELPYFREHPQDlg-llASHGEPLTRNVVALVRGt---GKRTLVMAG 94  Sinorhizobium m...
P54551         7 DELLALLTSLVQYESITGSkGEVALAEYLYFILKDKPYFQKHPDDv---tLHPMDDGRSFLTALVKKk--nVKKTVLLLS 81  Bacillus subtil...
EFV76394      10 DALRRLLCEVVSWKSMTLTeGEREFSFKVTAKLKELTYFRENSDHl---gLHDADLGRRFVTALYKHp--dATETIVLIS 84  Bacillus sp. 2_...
EFV78782      12 QQAEYLTKALVKMKSYNHSdGERHKADFLKEIIHSYPSFNDNDNLvwtqeIPGDELGRKNVFAFLKGrs-gGKRTILYLA 90  Bacillus sp. 2_...
ADV06588       9 AGRALLLKQLVAHQSVTHSeGEQSFPYLVKDQLMSLDYFKAHPEQi---hLVPTDDGRHAVVALYLGa--tSHKAVTCIS 83  Staphylococcus ...
Feature 1        #                                                           #                   
P39635        92 HLDTVGIEDFGPLKDIAFDCEKLAEYFSRYe--------FDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFSenl 163 Bacillus subtilis
NP_347007     86 HMDTVAVDDYGSLKDYAFDPDILQKKLKEIe--------LPEEVREDLDSGDWMFGRGASDMKSGDAVHLVVLKELSkrv 157 Clostridium ace...
YP_001255403  84 HLDVVDIDEFGILKNIAFDYKEYTKRVSDLv--------LDQDSKKDLYSNEWIFGRGTADMKYGLALYIELIRELSk-d 154 Clostridium bot...
NP_832724     84 HFDVVDVQDYGMWKEDAFNPKKLTSMFYSHkd------eLPDHVREDIEHGEWLFGRGTMDMKCGLALQMAMIEQACe-- 155 Bacillus cereus...
NP_437944     95 HFDTVSTDNYHELKALACDSLALKDALIESlsartgrseQEERALQDLASGDFLPGRGLLDMKSGLAVAIACLEQFAa-d 173 Sinorhizobium m...
P54551        82 HFDVVDIEDYGEFKHMACKPAELLSSFLEKke------lLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMn-- 153 Bacillus subtil...
EFV76394      85 HFDTVNTEEYGDLQEYAHLPEELTKLLHSRad------eLPEEARQDLLSGEFLFGRGTMDMKMGLVMHMGLLEKATv-- 156 Bacillus sp. 2_...
EFV78782      91 HLDTVGTEDFGPIQGMAHDPDKLQEFFVQYg--------SDPEVQEDALSEEWLFGRGALDMQSGVAVHLANLLFFSenp 162 Bacillus sp. 2_...
ADV06588      84 HFDTVGIEDFGLYQSEAFDMDRLTATFQGHve------dFDKEVQVDIQSGQYLFGRGSMDMKPGLMLHMSLIEKAIi-- 155 Staphylococcus ...
Feature 1                      ##                              #                                 
P39635       164 ETLPGNVLFMANPDEEsQHSGILASISELnRLKKEKQLHYLAAINTDfITPLYDGDQTRYIYTGAAGKLLPCFYIYGREV 243 Bacillus subtilis
NP_347007    158 KDISGNILFMSNPVEEnEHNGIREALDTLeKLKEKYSLEYTLAINNDyICPMYKGDNTRYLYTGTVGKLLPAFYFVGKET 237 Clostridium ace...
YP_001255403 155 RDFKGNILFLAVPGEEsNSEGMLGAIPYL-SKLKEDGYNFKSLFLSEcCIPKYEGDDAKRIYIGSVGKIMPTFFCVGKAT 233 Clostridium bot...
NP_832724    156 ERFDGNVLLLAVPDEEvNSVGMRAAVPRLlELAREHDLEYKTVLNSEpMFSRHPGDQNKYIYTGSIGKVLPGFLCYGKET 235 Bacillus cereus...
NP_437944    174 TDRQGNLMLVATPDEErESRGMRSLRDALpGLVRDFDIEIAGGINLDvTSDQGDGSEGRAVYAGTIGKLLPFALVIGCSS 253 Sinorhizobium m...
P54551       154 GHFEGNLLLITVPDEEvNSRGMIEAVPALkEMEKKHDITLTACLNAEpMFEKFPGDQQQYFYTGSIGKVLAGFFCKGIET 233 Bacillus subtil...
EFV76394     157 ERWPINLILLTVPDEEvNSSGMRAAVQKLlELKEKHQLTYKLFLNGEpVFTQEPGDRNYYVYSGSIGKIMPAALFYGKET 236 Bacillus sp. 2_...
EFV78782     163 DELNGNLLVMFNADEEgEHKGSRAALAELlRLKEKMGLEYLAAINNDfISPLYDGDTTKYIYTGTAGKILPCFSIFGRET 242 Bacillus sp. 2_...
ADV06588     156 EQWDINLILMTVPDEEvTSKGMHAAVAHLdELCQQHQLDIVLHLNSE-PTFQQQGNDIHYFYSGSIGKIMPGVFVNGRET 234 Staphylococcus ...
Feature 1                                                                                        
P39635       244 HVGDTLAGIDPNFISSEITSRLHNNIHLAEKVEGELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLL 323 Bacillus subtilis
NP_347007    238 HVGQCFEGINADVIASEVINEIDLNVDLCDEYNGEYTLPPSVLKFKDLKESYNVQTPFSSFAYFNYTVHSESPKQASEKL 317 Clostridium ace...
YP_001255403 234 HVGNPFGGVNPNLLVSEINRLMEYNVELSDKYEKDITPPPVCLKQSDLKELYSVQNPVYAYSYYNLLTIQKTPEEIMENL 313 Clostridium bot...
NP_832724    236 HVGEPFAGLNGSYMASLITAELELNTDLCDIVEGEASPPPTNLLQRDLKEDYSVQIPHRAVTLFNLFLLEKSMTDVVSLL 315 Bacillus cereus...
NP_437944    254 HASYPFEGVSAQAMAAGILARLEGNASLADRDDNDISPPPICLEAKDLRDGYEVTTPERFWIAFNWLYHSMTADALFERF 333 Sinorhizobium m...
P54551       234 HVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNLMQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQML 313 Bacillus subtil...
EFV76394     237 HVGEPLSGITAPYIASFLTQRMEWNTALQESEKGEQTPLPVTLQQKDLRLEYSAQTPYRSAALYNVFLMKRNAGEIMDIF 316 Bacillus sp. 2_...
EFV78782     243 HAGESLAGIDPTLIAAELTARISQNFQLTEKLEGELVLPPSCLYMRDDKKRYDVQTAVGCRVYFNYFFYEKPLKQLSKEL 322 Bacillus sp. 2_...
ADV06588     235 HVGTPALGLSSNFMMSYILQEIEYSARFKETFEGESTPFPVTLKMNDVKHHYDVQTPFRTVALFNLFLFKQNANDVFQQF 314 Staphylococcus ...
Feature 1                                                                                        
P39635       324 IEVTEEACreteqklsdyyEEYVKRANLPKKhlsw-----giqVYSLEQYLEKLRNRGid--pEQCIEQTFKan--ehLE 394 Bacillus subtilis
NP_347007    318 KKAAKRAFervi---krndDRYKKYCEMTNQkyepl--nfqakVITYTQLYTLAKARFsg-dlDKEIKSYEQrlvdnyVD 391 Clostridium ace...
YP_001255403 314 KDIARKAFyntl---kiikENYKKYKAIYESkleadl-diepkIITFEELYKEVLKENkd--fEKYIETAIEkwkeekLD 387 Clostridium bot...
NP_832724    316 RQKVTKVAek-------ieESYEKHAYRFSKynpfippnlkvnVLTYEELITYAIEQHgrgkiNHIQSNIIKnr--gdKD 386 Bacillus cereus...
NP_437944    334 REEVLTGAneaietfaaqsAEYGKLVGRSAGglpa-----kprLLSFQELRAAAARVFgh-gfDAFYAEKERefa-qsDN 406 Sinorhizobium m...
P54551       314 LKTAEQAAee-------imSNVRKKTQDFQQfepfqpierdvtVLTFDELVSRAKKRAgisetERALNYAFAnr--geLG 384 Bacillus subtil...
EFV76394     317 EKVALKAAhi-------cnEAYKEICSEQNVspvg-----evrVLRYEELEKHAIRKFga-afVAGIKDYVQkk--aeWD 381 Bacillus sp. 2_...
EFV78782     323 GMIAEDAAiavehrlkgayKDFRTVNKLPERqldw-----gteVTALDDFLVYLEQKGid--tVSVMEEARKqsslkeTD 395 Bacillus sp. 2_...
ADV06588     315 NAAVKEGMhk-------awAAYQQRMKDEDVaplp-----qlqLLTYQELYQYACQHHg----ERAVQDRVDqaiqneQE 378 Staphylococcus ...
Feature 1                                                                                        
P39635       395 LRMRCFQAIEELQKlDPDQGAKVILFYAPPYLP--HNYLked----sarDQLLQHVIKEAadktae---stgetfVFKKF 465 Bacillus subtilis
NP_347007    392 IREISLRVVDKVFNiWGEKKPCIVMFFAPPYCP--HNTLnvknekekeiINKIKECAQQLkekeg-----ineefKVMQF 464 Clostridium ace...
YP_001255403 388 NQTIGIKIIKETFEhYKYQQPMIIIAYNVPYYP--HRYFds-------eNPKYTNLLNSLdnmgiyakekynvniEKENF 458 Clostridium bot...
NP_832724    387 DRAVTIDLVDKLAIlCKEKAPMIVLFFAPPYYP--AVSSr--------nNPLIKEVVVEMekyahy---nhkitfENQNY 453 Bacillus cereus...
NP_437944    407 PLVATRQLTEWLVGiARLSGPAIVIGFSGLHYPpsHLRLae------gnDRSLHQAIEKAraglgn---dparslIWKPH 477 Sinorhizobium m...
P54551       385 DRDFSTKIVSELASlCKEDAPLIVLFYSPPLYP--AVSSk--------dDQLIRNTADQIkhyaae---rygialREVQY 451 Bacillus subtil...
EFV76394     382 DREKSIRIADALIIkCQELTPAIVLLYAPPYYP--AVNSs--------eDELVTECIEYVkqqgfe---kfglpvNQVHY 448 Bacillus sp. 2_...
EFV78782     396 ARMIAFDIVEALHQsDPEKKPRVVLFYGTPFLP--ANTVdvn----terGVFLKDCLEEVlaeeak---ktgeafKVRKY 466 Bacillus sp. 2_...
ADV06588     379 PHAQSILIIDALIRlCKSLGPVVVTFFAPPYYP--ATNAs--------fHPLVEAIKQTItdtakq---qfnrvsERIHY 445 Staphylococcus ...
Feature 1                                                                  #                     
P39635       466 FPYLADGSFLslhetDGEIDSFIRNfpgwnmIGTIPf-KDIRKLNIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQ 544 Bacillus subtilis
NP_347007    465 FPSLSDSSYLkidddSEGIESLTSNfpgwdrVYGVPv-QKIKDLNIPAINYGCYGKDAHKWTERVYKPYSFEVLPKLIML 543 Clostridium ace...
YP_001255403 459 FMGISDLSYTgl-deKFNIESICGNmpglgyTYKFPe-KELKKFDIPSVVFGGFGKDFHKYTERLDIPYSMDIVPELYMY 536 Clostridium bot...
NP_832724    454 FGGISDLSYVglqypLDSMSSLVDNmplwdkGYSIPl-QELEEFDVPVLNMGPVGKDAHQWTERLDVNYAFETLLDMLPK 532 Bacillus cereus...
NP_437944    478 FYGISDMSFLgl--aASGSQVVSDNt----pISRLVdrPSENALRFPTVNLGPWGREFHQKFERVHEPYAFRVLPELVSE 551 Sinorhizobium m...
P54551       452 FPGLSDLSYLql--eKQEVDAYTSNmplfnrGYSLPs-GKNQALYVPVLNVGPAGKDPHKWTERLYMPYSFEVLPDLLSF 528 Bacillus subtil...
EFV76394     449 FNGISDLSYVnyqdaGDGWIVFKENtpvwgsSYSIPf-DEMTQLQAPVLNVGPFGKDAHKRTERLHIKSAFEEVPALVEG 527 Bacillus sp. 2_...
EFV78782     467 FPYLSDGSFLsfdgsDEDIQSLKKNfpaiknLFPIPl-KAMRDLNIPVINLGVYGKAGHKWTERVYKPYTFEVLPEIIRK 545 Bacillus sp. 2_...
ADV06588     446 FNGISDLSYVapspnGSGFDAFRDHtpvfgqTYHIPf-EAIERIQAPFLNCGPIGKDAHKVTERVHQQSAFEELPIILET 524 Staphylococcus ...
Feature 1              
P39635       545 TTVHLL 550 Bacillus subtilis
NP_347007    544 TIEKFL 549 Clostridium acetobutylicum ATCC 824
YP_001255403 537 ILKEML 542 Clostridium botulinum A str. ATCC 3502
NP_832724    533 CIEKLL 538 Bacillus cereus ATCC 14579
NP_437944    552 IARTFL 557 Sinorhizobium meliloti 1021
P54551       529 TISALL 534 Bacillus subtilis subsp. subtilis str. 168
EFV76394     528 MVKMLA 533 Bacillus sp. 2_A_57_CT2
EFV78782     546 VTRRIL 551 Bacillus sp. 2_A_57_CT2
ADV06588     525 IIKTHF 530 Staphylococcus pseudintermedius HKU10-03

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