1TZC,1WIW,1X9I


Conserved Protein Domain Family
SIS_PGI_PMI_2
?
cd05637: SIS_PGI_PMI_2 
Click on image for an interactive view with Cn3D
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the second SIS domain.
Links
?
Statistics
?
PSSM-Id: 240188
Aligned: 32 rows
Threshold Bit Score: 87.0206
Created: 28-Mar-2007
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active sitedimer interface
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1X9I_A: Pyrobaculum aerophilum (PGI/PMI) binds glucose 6-phosphate, contacts calculated at 3.5A
  • Structure:1TZC_A: Pyrobaculum aerophilum PGI/PMI binds enzyme inhibitor 5-phosphoarabinonate, contacts calculated at 3.5A
  • Comment:phosphoglucose/phosphomannose isomerase (PGI/PMI)
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            #                                           
1TZC_A       169 ALIHKLVEefq-krPTIIAae-sMRGVAYRVKNEFNENAKi--ePSVEILPEAHHnwie-------gserAVVALTSph- 236 Pyrobaculum aer...
1WIW_A       151 NPAKFLAYtllerlPLFYSp--lFRPLEGAVQTLFARVAKs--lSLTPPPSALEFflvglea--rheqgdPLAAVLLgp- 223 Thermus thermop...
1X9I_A       169 ALIHKLVEefq-krPTIIAae-sMRGVAYRVKNEFNENAKi--ePSVEILPEAHHnwie-------gserAVVALTSph- 236 Pyrobaculum aer...
CAF18453     166 ALEERLKSvis-rrPTIVApa-sMQGVAYRVKNEINENAKm--dSPVEILPEAHHnwie-------gassPLMALTSeq- 233 Thermoproteus t...
YP_290564    213 NPAKELALafadtlPVLWGatplTALAARWAAVQFAANARy--pVLLPSPPEAAW---------------AQPAVLTgpl 275 Thermobifida fu...
YP_605064    142 NPARELAWtlwgrtPLLLAae-gAEALPHAWQALLARVGKtlavPLLGDPLALVTgafe--------aqhEKGDAKVal- 211 Deinococcus geo...
YP_711525    209 NPAKTLALelagslPLVWGtsavTSVAAEHVAAQLAAIAKy--pAIVGALPHPGHhqvalfdgpfgagltAGSTAGGtga 286 Frankia alni AC...
NP_147479    179 RLAGFISRyr---iASLVTcg-pGIPLAVRLKNELAENAKm--pSRLEIYPESSHndiv-------aleaAEGLYGAvf- 244 Aeropyrum perni...
YP_001013616 186 RLVDWLGTvaggwlSIVAAe--pYYPAAVRFRSELAENAKl--aSDASQVPEAGHniiv-------gmagRRDTALLil- 253 Hyperthermus bu...
YP_001041159 179 ELSSFIDEhk--glPILATht-pFEALVVRGKNEFNENSKi--pVKVEVAPEWMHndiv-------gwekPFENKYSai- 245 Staphylothermus...

Feature 1                                                                                        
1TZC_A       237 ----------ipKEHQERVKATVEiv---------gGSIYAve------------------------mhPKGVLSFLRDV 273 Pyrobaculum aer...
1WIW_A       224 -----------gEEAALAKEILESr----------vDALAEvpat--------------------ganrLAQVXALWYRX 262 Thermus thermop...
1X9I_A       237 ----------ipKEHQERVKATVEiv---------gGSIYAve------------------------mhPKGVLSFLRDV 273 Pyrobaculum aer...
CAF18453     234 ----------ipLEHRRRVEITVDlv---------gGELFKvd------------------------mtIGGVLTFLKHV 270 Thermoproteus t...
YP_290564    276 qa-----srglfDDPADAPGIRMRlllf----rddeALPEEaadlaraehtaetaevlvsevaaqgrspVERLAGLIALI 346 Thermobifida fu...
YP_605064    212 ----------llGDTDPALSIVREvletr--idevlHVPYPasaga------------------eqpagYAAQLALWYLG 261 Deinococcus geo...
YP_711525    287 rddledffrdriSDEEESIRLRLIllrdpdverpevGRQAEsavavaaergvg-----vtelraegagpLERLASLIGLF 361 Frankia alni AC...
NP_147479    245 ----------iwIEHEGSLCPAVLdvveg--iyreyGVDTIsiessar---------------ggpnatVAEYLSRTLVF 297 Aeropyrum perni...
YP_001013616 254 ----------dpVEEPWTTILKGFaea------vgpASSYTlrlr--------------------gkgmLPKLVWATWIA 297 Hyperthermus bu...
YP_001041159 246 ----------iiRDPSDDVGSKLVdfmkk--iyinnNIPIYelelh-------------------gktfLEKLLYGSLVL 294 Staphylothermus...

Feature 1                       
1TZC_A       274 GIASVKLAEIRGVNP 288 Pyrobaculum aerophilum str. IM2
1WIW_A       263 AWTAYYLALLYGVDP 277 Thermus thermophilus
1X9I_A       274 GIASVKLAEIRGVNP 288 Pyrobaculum aerophilum
CAF18453     271 GLATAKLALERGIDP 285 Thermoproteus tenax
YP_290564    347 DYATLYLAVAYAVEP 361 Thermobifida fusca YX
YP_605064    262 AWVAAYLAERYGVDP 276 Deinococcus geothermalis DSM 11300
YP_711525    362 DFTAVYAALALGIDP 376 Frankia alni ACN14a
NP_147479    298 GLASVRLALMRGFNP 312 Aeropyrum pernix K1
YP_001013616 298 GLSSTLYAERHGLDP 312 Hyperthermus butylicus DSM 5456
YP_001041159 295 GLASVKLARIRGVDP 309 Staphylothermus marinus F1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap