2GGO


Conserved Protein Domain Family
LbH_G1P_TT_C_like

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cd05636: LbH_G1P_TT_C_like 
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Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that resemble a dinucleotide-binding Rossmann fold and C-terminal LbH fold domains. Members in this family are predicted to be glucose-1-phosphate thymidylyltransferases, which are involved in the dTDP-L-rhamnose biosynthetic pathway. Glucose-1-phosphate thymidylyltransferase catalyzes the synthesis of deoxy-thymidine di-phosphate (dTDP)-L-rhamnose, an important component of the cell wall of many microorganisms. The C-terminal LbH domain contains multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.
Statistics
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PSSM-Id: 100060
View PSSM: cd05636
Aligned: 25 rows
Threshold Bit Score: 210.907
Threshold Setting Gi: 34498558
Created: 8-Nov-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2GGO_A       228 FSQNLG---NVEDNVKIKGKVIIEEDAEIKSGTYIEGPVYIGkgSEIGPnSYLRPyTILVEkNKIGASVEVKESVIMEgS 304 Sulfolobus toko...
NP_147781    240 SGGVEGevhSSAVLEGDVERIYIARGARIGAHSVVEGPAYIGpgARVGPgAHVRGyTVLLEgAYVGFASEVKASVIMEgA 319 Aeropyrum perni...
YP_008996     42 LGVLLGs-iSPQAYLIRPEEITIGEGSIVEPGAYIQGPCWIGnhCVIRHgAYIRGyVITGDyCVIGHDTEVKNSLFLNrA 120 Candidatus Prot...
ZP_02010957   92 AHAVKE---AVSAAVRIEGTVWIDPSVKLPAYATIIGPAWIGagTEIRPgAFVRGnVITGEgCVLGNACEFKNCLLLDgV 168 Opitutaceae bac...
EDP16820      39 FIESLGaslPENEYKKIGKNIWIHKTAQMAPTTAMGGPMIIGpkVQIRNgAFLRGgVILGQhVVIGNSCEIKNSIIFDeA 118 Clostridium bol...
YP_001435462 243 KMEFEV---REGLENPWGPGKVYGELPEVKGEVYVEGPVYFGegVVLGPfAHVRPyVALLDgVKVGPFVQVKESMIMEgS 319 Ignicoccus hosp...
YP_066659     90 GRILEGaslIMAGASLIGDQISLGKGVLVETGAMIKSPTIIGdyCEIRQgAYLRGyCLAGAgCVLGHSTEIKHSIMLDgA 169 Desulfotalea ps...
EDO60869      38 FILALGpslPKDEYEEIKENVWAAKSAVIFPTAYLNGPVIIGknTEVRHgAFIRGsALVGDsAVVGNSTELKNVILFNnV 117 Clostridium lep...
ZP_02036022   60 LILSLGsqlSPEEYSQPREHVWVHKTAVVAPTAYLGAPCIIGpeTEIRHcAFIRGsALVGAhCVVGNSAELKNSILFDeV 139 Bacteroides cap...
YP_610285     34 VMALLG---RLPPGYRRQGDCAVHETATVETGAVLKGPIIIGagCFVAAgAYLRGgVYLGRqCIVGPSCEVKSSFMLDgS 110 Pseudomonas ent...
2GGO_A       305 KIPHLSYVGDSVIAEdVNFGAGTLIANLRFDEKEvkvnvk--------gkrisSGRRKLGAFIGGHVRTGINVTILPGVK 376 Sulfolobus toko...
NP_147781    320 RAPHLNYVGDSVVGEhVNLGAGTVTANLRFDGRSvrmtvk--------gervdTGLRKLGAVIGGYAQTGINVSIMPGVR 391 Aeropyrum perni...
YP_008996    121 HAAHFAYVGDTILGHdVNLGAGTKCANFKLDQQTvsvvyk--------hqhfdTQLRKFGAIIGDRSQIGCNTVTNPGSL 192 Candidatus Prot...
ZP_02010957  169 QVPHFSYVGDSILGNkAHLGAGVICSNLRLDQKAitvrlpattegtanggvvnTGLRKFGALLGDGAEAGCNSVLNPGSI 248 Opitutaceae bac...
EDP16820     119 QVPHFNYVGDSILGYkAHMGAGAVTSNVKADKGLvkvhae--------dgdveTGRKKFGAILGDHAEIGCNSVLNPGTV 190 Clostridium bol...
YP_001435462 320 RLPHLNYVGDSVVAEdVNFGAGSVTANLRFDEREvevtlk--------gqrvsTGRRKLGAIVGGGARIGVNVSLMPGTR 391 Ignicoccus hosp...
YP_066659    170 KAGHFNYLGDSILGNnTNLGAGTKLANLRFLPGNvhilhd--------kkqidSGLRKFGAIMGDDSQTGCNSVTSPGTV 241 Desulfotalea ps...
EDO60869     118 QVPHYNYVGDSILGYrSHMGAGSITSNVKSDKTLvtvkyq--------gekitTGLKKFGAILGDCVEVGCNSVLNPGSV 189 Clostridium lep...
ZP_02036022  140 QTPHYNYVGDSILGYkSHMGAGSVTSNIKSDKTSvvika---------etdifTGRRKVGAVLGDFVEVGCNSVLNPGTI 210 Bacteroides cap...
YP_610285    111 KLAHFNFVGDSLIGAnVNVEAGAIIANYRNELDGapirirh------gdkvieTAVSKFGALIGDGCKIGANAVIAPGAL 184 Pseudomonas ent...
2GGO_A       377 IGAyARIYPGAVVN 390 Sulfolobus tokodaii str. 7
NP_147781    392 IGPrALVYPGCVVG 405 Aeropyrum pernix K1
YP_008996    193 IGMdVRAYPCLNIG 206 Candidatus Protochlamydia amoebophila UWE25
ZP_02010957  249 LGRrALVMPTVAFA 262 Opitutaceae bacterium TAV2
EDP16820     191 IGRnSNVYPLSSVR 204 Clostridium bolteae ATCC BAA-613
YP_001435462 392 VGArSWIYPGCVVR 405 Ignicoccus hospitalis KIN4/I
YP_066659    242 LGKkCMLMPNTTTK 255 Desulfotalea psychrophila LSv54
EDO60869     190 ICPnSNIYPLSMVR 203 Clostridium leptum DSM 753
ZP_02036022  211 LGRhSIVYPTSCVR 224 Bacteroides capillosus ATCC 29799
YP_610285    185 LLPgTQVPRLGLID 198 Pseudomonas entomophila L48
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